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    ANTIVIRAL AZASUGAR-CONTAINING NUCLEOSIDES
    5.
    发明公开
    ANTIVIRAL AZASUGAR-CONTAINING NUCLEOSIDES 审中-公开
    抗病毒核苷AZAZUCKERHALTIGE

    公开(公告)号：EP2919785A4

    公开(公告)日：2016-10-05

    申请号：EP13855441

    申请日：2013-11-18

    申请人： BIOCRYST PHARM INC

    发明人： BABU YARLAGADDA S ,  KOTIAN PRAVIN L ,  BANTIA SHANTA ,  WU MINWAN ,  KUMAR V SATISH

    IPC分类号： A61K31/505 ,  C07D401/04 ,  C07D487/04

    CPC分类号： C07D487/04 ,  A61K31/519 ,  C07D401/04 ,  C07D403/04

    摘要： Disclosed are compounds comprising an azasugar attached to a heterocyclic base, including pharmaceutically acceptable salts thereof, suitable for use in inhibiting viral RNA polymerase activity or viral replication, and treating viral infections. The compounds are characterized, in part, by favorable pharmacokinetics for the active pharmaceutical ingredient, particularly in conjunction with enteral administration, including, in particular, oral administration. Also disclosed are pharmaceutical compositions comprising one or more compounds mentioned above, or pharmaceutically acceptable salts thereof, as well as methods for preparing same. Also provided are methods for inhibiting viral RNA polymerase activity, viral replication, and treating viral infections.

    METHODS AND COMPOSITIONS FOR INHIBITION OF POLYMERASE
    6.
    发明公开
    METHODS AND COMPOSITIONS FOR INHIBITION OF POLYMERASE 有权
    VERFAHREN UND ZUSAMMENSETZUNGEN ZUR POLYMERASEHEMMUNG

    公开(公告)号：EP2627334A4

    公开(公告)日：2014-04-16

    申请号：EP11833515

    申请日：2011-10-14

    申请人： BIOCRYST PHARM INC

    发明人： BANTIA SHANTA ,  KOTIAN PRAVIN L ,  BABU YARLAGADDA S

    IPC分类号： A61K31/519 ,  A61K31/215 ,  A61K45/06 ,  A61P31/14

    CPC分类号： A61K31/519 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/196 ,  A61K31/215 ,  A61K31/351 ,  A61K31/7064 ,  A61K45/06 ,  C07D487/04 ,  C07H7/06 ,  A61K2300/00

    摘要： The present invention is directed to methods and compositions for inhibition of viral nucleic acid polymerases, such as RNA and DNA polymerases, and methods and compositions that are useful for treating viral infections in subjects. The methods comprise administering to the subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or hydrate thereof, or a composition comprising a compound of formula I, or a pharmaceutically acceptable salt or hydrate thereof, and a pharmaceutically acceptable carrier. The composition or method may optionally comprise one or more additional anti-viral agents.

    摘要翻译： 本发明涉及用于抑制病毒核酸聚合酶（例如RNA和DNA聚合酶）的方法和组合物，以及可用于治疗受试者的病毒感染的方法和组合物。 所述方法包括向受试者施用治疗有效量的式I化合物或其药学上可接受的盐或水合物，或包含式I化合物或其药学上可接受的盐或水合物的组合物和药学上可接受的 载体。 组合物或方法可任选地包含一种或多种另外的抗病毒剂。