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1.发明公开
公开(公告)号：EP0933993A4
公开(公告)日：2004-09-08
申请号：EP97931014
申请日：1997-06-13
申请人： BIOCRYST PHARM INC
IPC分类号： C07D295/18 , A01N37/12 , A01N37/18 , A01N47/44 , A61K31/00 , A61K31/04 , A61K31/045 , A61K31/08 , A61K31/155 , A61K31/16 , A61K31/18 , A61K31/19 , A61K31/195 , A61K31/275 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/445 , A61P31/00 , A61P31/16 , C07C61/06 , C07C62/02 , C07C69/757 , C07C233/47 , C07C237/22 , C07C279/14 , C07C279/16 , C07D205/04 , C07D211/16 , C07D211/70 , C07D295/185 , A01N37/52 , C07C61/04 , C07C233/00 , C07C281/00
CPC分类号： C07D295/185 , C07C61/06 , C07C62/02 , C07C69/757 , C07C233/47 , C07C279/14 , C07C279/16 , C07C2601/08 , C07D205/04
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公开(公告)号：EP1814561A4
公开(公告)日：2012-12-19
申请号：EP05820258
申请日：2005-10-28
申请人： BIOCRYST PHARM INC
发明人： BABU YARLAGADDA S , CHAND POORAN , WU MINWAN , KOTIAN PRAVIN L , KUMAR V SATISH , LIN TSU-HSING , EL-KATTAN YAHYA , GHOSH AJIT K , HARRIS ROBERT J
IPC分类号： A61K31/7064 , A61P31/12
CPC分类号： C07D495/04 , A61K31/675 , A61K31/7076 , A61K38/212 , A61K38/2292 , C07D491/048 , C07D493/04 , C07F9/6561 , C07H7/06 , C07H19/22 , A61K2300/00
摘要： The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula I, II, and III are useful as anti-viral agents and/or as anti-cancer agents.
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3.发明公开SUBSTITUTED CYCLOPENTANE AND CYCLOPENTENE COMPOUNDS USEFUL AS NEURAMINIDASE INHIBITORS 有权取代环戊烷和环戊烯化合物作为神经氨酸酶受体阻滞剂
公开(公告)号：EP1040094A4
公开(公告)日：2004-12-08
申请号：EP98966003
申请日：1998-12-17
申请人： BIOCRYST PHARM INC
IPC分类号： A61K20060101 , A61K31/195 , A61K31/196 , A61K31/215 , A61K31/385 , A61K31/4164 , A61K31/423 , A61P31/12 , A61P43/00 , C07C20060101 , C07C229/32 , C07C229/48 , C07C233/47 , C07C247/14 , C07C271/24 , C07C279/16 , C07C279/24 , C07C309/66 , C07C323/41 , C07C323/43 , C07C323/59 , C07C323/60 , C07D20060101 , C07D233/54 , C07D233/56 , C07D261/20 , C07D339/08 , C07D521/00 , C07C69/74 , C07C49/105 , C07C49/297 , C07C49/395 , C07C49/597 , C07C61/06 , C07C61/20 , C07D341/00
CPC分类号： C07D231/12 , C07C229/48 , C07C233/47 , C07C247/14 , C07C271/24 , C07C279/16 , C07C279/24 , C07C309/66 , C07C323/59 , C07C323/60 , C07C2601/08 , C07C2601/10 , C07D233/56 , C07D249/08 , C07D261/20 , C07D339/08
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4.发明公开NUCLEOSIDES PREPARATION THEREOF AND USE AS INHIBITORS OF RNA VIRAL POLYMERASES 审中-公开核苷，生产与应用，RNA病毒聚合酶的抑制剂
公开(公告)号：EP1450809A4
公开(公告)日：2006-07-19
申请号：EP02807245
申请日：2002-11-14
申请人： BIOCRYST PHARM INC
发明人： BABU YARLAGADDA S , CHAND POORAN , EL-KATTAN YAHYA , WU MINWAN
IPC分类号： A61K31/13 , A61K31/575 , A61K31/66 , A61K31/662 , A61K31/663 , A61K31/704 , A61K31/7056 , A61K36/28 , A61K38/20 , A61K38/21 , A61P31/14 , A61P31/16 , A61P31/20 , A61P43/00 , C07F9/10 , C07F9/6512 , C07F9/6561 , A61K31/505 , A61K31/51 , A61K31/513 , A61K31/52 , C07D239/36 , C07D473/34
CPC分类号： C07F9/65616 , A61K31/13 , A61K31/66 , A61K36/28 , A61K38/20 , A61K38/208 , A61K38/21 , A61K38/212 , C07F9/10 , C07F9/65121 , C07F9/65122 , A61K2300/00
摘要： Compounds represented by the formula: Wherein A is -(CH2)n-R, -CH=CH2, -CH2-CH=CH2, -O-(CH2)n-R, -CH(OH)CH3, -CH(OH)-CH2OH, -CH2-CH(OH)CH3, -CH2-CH(OH)-CH2OH, -CH(OH)-CH(OH)-CH3; R is H, OH, F, N3, NH2, CO2H, SH, alkyl, S-alkyl, O-acyl, CONH2, CONH-alkyl; Z and Z' independently is OR , OR , O-(CH2)n-O-alkyl or aminoacids and esters thereof; R and R independently is H, alkyl, aryl, pivaloyloxymethyl, phthalyl or substituted phthalyl, C(R )2OC(O)X(R )a, R is -H, C1-C12 alkyl, C5-C12 aryl, C2-C12 alkenyl, C2-C12 alkynyl, C7-C12 alkenylaryl, C7-C12 alkynylaryl, or C6-C12 alkaryl, any of which is unsubstituted or is substituted with 1 or 2 halo, cyano, azido, nitro, or -OR ; R is -H, C1-C12 alkyl, C5-C12 aryl, C2-C12 alkenyl, C2-C12 alkynyl, C7-C12 alkenylaryl, C7-C12 alkynylaryl, or C6-C12 alkaryl, any of which is unsubstituted or is substituted with 1 or 2 halo, cyano, azido, nitro, -N(R )2 or -OR ; R is C1-C12
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公开(公告)号：EP1383731A4
公开(公告)日：2005-09-28
申请号：EP01981772
申请日：2001-10-22
申请人： BIOCRYST PHARM INC
发明人： BABU YARLAGADDA S , ROWLAND SCOTT R , CHAND POORAN , KOTIAN PRAVIN L , EL-KATTAN YAHYA , NIWAS SHRI
IPC分类号： C07D295/14 , A61K31/11 , A61K31/192 , A61K31/235 , A61K31/255 , A61K31/27 , A61K31/277 , A61K31/341 , A61K31/352 , A61K31/36 , A61K31/366 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/416 , A61K31/4164 , A61K31/4178 , A61K31/4184 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/453 , A61K31/496 , A61K31/506 , A61K31/535 , A61K31/616 , A61K31/69 , A61K31/695 , A61K31/727 , A61K38/46 , A61K38/48 , A61K45/00 , A61P7/02 , A61P9/10 , A61P29/00 , A61P43/00 , C07C229/38 , C07C233/54 , C07C233/65 , C07C235/84 , C07C251/48 , C07C255/57 , C07C255/58 , C07C257/12 , C07C257/18 , C07C259/18 , C07C259/20 , C07C271/22 , C07C271/64 , C07C309/65 , C07D207/32 , C07D207/337 , C07D209/08 , C07D213/40 , C07D213/55 , C07D213/56 , C07D213/74 , C07D213/75 , C07D213/78 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/56 , C07D233/24 , C07D233/54 , C07D233/61 , C07D233/64 , C07D235/10 , C07D235/14 , C07D235/30 , C07D235/32 , C07D239/14 , C07D239/42 , C07D239/48 , C07D277/20 , C07D277/30 , C07D277/82 , C07D295/16 , C07D307/54 , C07D311/80 , C07D317/46 , C07D317/60 , C07D317/68 , C07D333/24 , C07D333/38 , C07D405/12 , C07D521/00 , A61P7/00 , C07C63/04 , C07C257/00 , C07C317/22 , C07D207/08 , C07D207/30 , C07D211/70 , C07D307/02 , C07D311/78 , C07D333/22
CPC分类号： C07D209/08 , A61K31/192 , A61K31/341 , A61K31/381 , A61K31/426 , A61K31/4418 , C07C229/38 , C07C233/54 , C07C235/84 , C07C251/48 , C07C255/57 , C07C255/58 , C07C257/18 , C07C259/18 , C07C259/20 , C07C271/22 , C07C271/64 , C07C309/65 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D207/337 , C07D213/40 , C07D213/56 , C07D213/74 , C07D213/75 , C07D213/78 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/56 , C07D233/56 , C07D233/64 , C07D235/14 , C07D235/30 , C07D235/32 , C07D239/14 , C07D239/42 , C07D239/48 , C07D249/08 , C07D277/30 , C07D277/82 , C07D307/54 , C07D311/80 , C07D317/46 , C07D317/68 , C07D333/24 , C07D333/38
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公开(公告)号：EP1893625A4
公开(公告)日：2012-12-26
申请号：EP06785264
申请日：2006-06-21
申请人： BIOCRYST PHARM INC
发明人： CHAND POORAN , WU MINWAN , KOTIAN PRAVIN L , KUMAR SATISH V , LIN TSU-HSING
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