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    Improved vectors and methods for making such vectors and for expressing cloned genes
    1.
    发明公开
    Improved vectors and methods for making such vectors and for expressing cloned genes 无效
    改进的载体，使这些载体用于表达克隆的基因的和方法。

    公开(公告)号：EP0041767A2

    公开(公告)日：1981-12-16

    申请号：EP81301413.1

    申请日：1981-04-01

    申请人： BIOGEN, INC.

    发明人： Fiers, Walter Charles ,  Remaut, Erik Rene

    IPC分类号： C12N15/52 ,  A61K39/135 ,  C07K15/00 ,  C12N15/73

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C07K14/565 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/75 ,  C12N15/52 ,  C12N15/73 ,  C12N2710/22022

    摘要： Improved vectors and methods for expressing cloned genes of prokaryotic or eukaryotic origin and methods of making such vectors are disclosed, the improved vectors comprising promoters and operators from λ phages and preferably do not include an active cro gene or an active N gene, the vectors having at least one endonuclease recognition site forcloning desired genes less than about 300 base pairs from the promoters and operators and being useful, as are methods utilizing the vectors, in producing a wide variety of prokaryotic, eukaryotic and viral polypeptides, hormones, enzymes, antigens, proteins and amino acids.

    摘要翻译： 改进的用于表达的原核或真核来源的克隆的基因，使搜索矢量的方法的载体和方法是圆盘游离缺失，改进的载体，其包括从拉姆达噬菌体启动子和运营商和优选地不包括在活性CRO基因或活性的N-基因，具有该矢量 至少一种内切核酸酶识别位点小于从启动子约300个碱基对和运营商和克隆目的基因是有用的，因为是利用方法的载体，在制造各种各样的原核，真核和病毒多肽激素，酶，抗原的 ，蛋白质和氨基酸。

    DNA sequences, recombinant DNA molecules and processes for producing human interleukin two-like polypeptides
    2.
    发明公开
    DNA sequences, recombinant DNA molecules and processes for producing human interleukin two-like polypeptides 失效
    DNA序列的重组DNA分子和用于生产人白细胞介素2样多肽的过程。

    公开(公告)号：EP0118977A1

    公开(公告)日：1984-09-19

    申请号：EP84300439.1

    申请日：1984-01-25

    申请人： BIOGEN, INC.

    发明人： Fiers, Walter Charles ,  Devos, Rene Robert

    IPC分类号： C12N15/00 ,  C12P21/00 ,  C07C103/52 ,  C12N5/00 ,  A61K37/02 ,  C12P19/30

    CPC分类号： C12N15/70 ,  A61K38/00 ,  C07K14/55

    摘要： DNA sequences, recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying a biological or immunological activity of human interleukin 2, the genes coding for these polypeptides and methods of making and using these DNA sequences, molecules, hosts, genes and polypeptides. The DNA sequences are characterized in that they code for a polypeptide displaying a biological or immunological activity of human interleukin 2. In appropriate hosts these DNA sequences and recombinant DNA molecules permit the production and identifiation of genes and polypeptides displaying a biological or immunological activity of human interleukin 2 and their use in immunotherapeutic agents and methods and in the establishment and longterm proliferation of T-cells.

    摘要翻译： DNA序列的重组DNA分子和宿主经转化withthem其产生多肽显示人白细胞介素2的生物学或免疫学活性，该基因编码的多肽的合成以及制备和使用这些DNA序列，分子，主机，基因和多肽的方法。 的DNA序列在thatthey码为特征的，用于显示的DNA序列和重组DNA分子的人白细胞介素2，适当的宿主合成的生物学或免疫学活性的多肽允许生产和基因的identifiation和多肽显示人类的生物学或免疫学活性 白细胞介素2及其在免疫治疗剂和方法以及在T细胞的建立和长期增殖的用途。