公开(公告)号：EP2507220A4

公开(公告)日：2013-05-01

申请号：EP10834885

申请日：2010-08-04

申请人： BIOTIUM INC

发明人： MAO FEI ,  LEUNG WAI-YEE ,  CHEUNG CHING-YING ,  HOOVER HYE EUN

IPC分类号： C07D311/00 ,  A61K49/00 ,  C07D335/00 ,  C07D491/22

CPC分类号： C07H15/26 ,  A61K49/0017 ,  C07D311/88 ,  C07D405/04 ,  C07D405/14 ,  C07D491/147 ,  C07D491/22 ,  C07F9/65586 ,  C07K1/13 ,  C07K16/00 ,  C07K16/2809 ,  C07K16/32 ,  Y10T436/25

摘要： The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

公开(公告)号：EP2686680A4

公开(公告)日：2014-12-10

申请号：EP12761364

申请日：2012-03-16

申请人： BIOTIUM INC

发明人： MAO FEI ,  LEUNG WAI-YEE ,  CHEUNG CHING-YING ,  HOOVER HYE EUN

IPC分类号： G01N33/50 ,  G01N33/543 ,  G01N33/58

CPC分类号： G01N1/30 ,  C07K1/13 ,  C07K17/06 ,  C09B11/24 ,  C09B23/06 ,  C09B23/083 ,  C09B57/001 ,  C09B57/02 ,  G01N33/53 ,  G01N33/532 ,  G01N33/533 ,  G01N33/582 ,  G01N33/6854

摘要： The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners.

公开(公告)号：EP2393805A4

公开(公告)日：2012-09-19

申请号：EP10739088

申请日：2010-02-03

申请人： BIOTIUM INC

发明人： MAO FEI ,  LEUNG WAI-YEE ,  CHEUNG CHING-YING

IPC分类号： C07D311/88 ,  C07D405/12 ,  C07D405/14 ,  C07D491/22 ,  C07K1/13

CPC分类号： G01N33/57484 ,  C07D311/88 ,  C07D405/12 ,  C07D405/14 ,  C07D491/147 ,  C07D491/22 ,  C07K1/13 ,  G01N33/582

摘要： The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

公开(公告)号：EP2223086A4

公开(公告)日：2011-05-04

申请号：EP08861025

申请日：2008-12-12

申请人： BIOTIUM INC

发明人： MAO FEI ,  LEUNG WAI-YEE ,  CHEUNG CHING-YING ,  HOOVER HYE EUN

IPC分类号： G01N21/64 ,  C09B69/00

CPC分类号： G01N33/582 ,  C09B11/08 ,  C09B11/24 ,  C09B23/0066 ,  C09B23/06 ,  C09B23/083 ,  C09B23/086 ,  C09B57/001 ,  C09B57/02 ,  C09B69/00 ,  G01N21/6428 ,  G01N2021/6439

摘要： The present invention relates to fluorescent dyes. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. In one aspect, the invention provides a compound having a maximal fluorescence excitation wavelength, wherein the compound has a structure of Formula II: F—Y=Ψ  Formula II and wherein Z— is a counterion, Y is a bridge unit permitting electron delocalization between F and Ψ, and F is a moiety having the structure: The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

公开(公告)号：EP1863933A4

公开(公告)日：2009-04-08

申请号：EP06738900

申请日：2006-03-17

申请人： BIOTIUM INC ,  ALLELOGIC BIOSCIENCES CORP

发明人： MAO FEI ,  LEUNG WAI-YEE ,  XIN XING

IPC分类号： C12Q1/68 ,  C07D213/02 ,  C07D401/02

CPC分类号： C12Q1/6876 ,  C07D209/08 ,  C07D213/38 ,  C07D221/10 ,  C07D417/06 ,  C07D417/14 ,  C07D491/147 ,  C07H21/00 ,  C09B15/00 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2563/173

摘要： Dimeric and trimeric nucleic acid dyes, and associated systems and methods are provided. Such a dye may form a hairpin-like structure that enables it to stain nucleic acids via a release-on-demand mechanism, for example. Such a dye may have low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, for example. A dye provided herein may be useful in a variety of applications, such as in DNA quantitation in real-time PCR, for example.