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公开(公告)号：EP0755402A1
公开(公告)日：1997-01-29
申请号：EP95915459.0
申请日：1995-03-31
CPC分类号： C12N15/113 , A01K67/0275 , A01K67/0276 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/108 , A01K2267/02 , A01K2267/025 , A61K2035/122 , C12N9/1051 , C12N15/1137 , C12N15/8509 , C12N2310/111 , C12N2310/121 , C12N2310/315 , C12N2517/02 , C12N2830/52 , C12N2840/203 , C12Y204/01228
摘要： Transgenic swine in which the normal expression of alpha(1,3) galactosyltransferase is prevented in at least one organ of tissue type. The absence or inactivation of this enzyme prevents the production of carbohydrate moieties having the distinctive terminal Galalpha1-3Galbeta1-4GlcNAc epitope that is a significant factor in xenogeneic, particularly human, transplant rejection of swine grafts.
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公开(公告)号：EP0755402B1
公开(公告)日：2008-05-14
申请号：EP95915459.2
申请日：1995-03-31
IPC分类号： C12N15/54 , C12N15/19 , A61K31/70 , A61K35/16 , C12N15/00 , A01K67/027 , C12N15/52 , C12N9/10 , C12N9/00
CPC分类号： C12N15/113 , A01K67/0275 , A01K67/0276 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/108 , A01K2267/02 , A01K2267/025 , A61K2035/122 , C12N9/1051 , C12N15/1137 , C12N15/8509 , C12N2310/111 , C12N2310/121 , C12N2310/315 , C12N2517/02 , C12N2830/52 , C12N2840/203 , C12Y204/01228
摘要： Transgenic swine in which the normal expression of alpha(1,3) galactosyltransferase is prevented in at least one organ of tissue type. The absence or inactivation of this enzyme prevents the production of carbohydrate moieties having the distinctive terminal Galalpha1-3Galbeta1-4GlcNAc epitope that is a significant factor in xenogeneic, particularly human, transplant rejection of swine grafts.
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