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    PYRIMIDIN-AMINOMETHYL-PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE CONTROL OF HELICOBACTER BACTERIA
    6.
    发明公开
    PYRIMIDIN-AMINOMETHYL-PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE CONTROL OF HELICOBACTER BACTERIA 有权
    嘧啶氨基甲基吡啶衍生物，其制备方法及其用来对付螺杆菌

    公开(公告)号：EP1091957A1

    公开(公告)日：2001-04-18

    申请号：EP99926348.6

    申请日：1999-05-20

    申请人： Byk Gulden Lomberg Chemische Fabrik GmbH

    发明人： HANAUER, Guido ,  KOHL, Bernhard ,  POSTIUS, Stefan ,  SENN-BILFINGER, Jörg ,  SIMON, Wolfgang-Alexander ,  OPFERKUCH, Wolfgang ,  ZIMMERMANN, Peter ,  GRUNDLER, Gerhard

    IPC分类号： C07D401/14 ,  A61K31/505 ,  C07D401/12 ,  C07D413/14

    CPC分类号： C07D413/14 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D487/04

    摘要： Compounds of formula (I) in which R1, R2 and R3 are hydrogen, 1-4C-alkyl or halogen, R4, R5, R6 and R9 are hydrogen or 1-4C-alkyl, R7 and R8 are hydrogen, 1-4C-alkyl, 1-4C-alkoxy or halogen, A is 1-7C-alkylene, 2-7C-alkenylene, 3-7C-cycloalkylene or phenylene, G is hydrogen, hydroxyl, 1-7C-alkyl, 1-4C-alkyl which is completely or mainly substituted by fluorine, 2-7C-alkenyl, 3-7C-cycloalkyl, a mono- or di-1-4C-alkylcarbamoyl or -thiocarbamoyl radical, an N-1-4C-alkyl-N'-cyanoamidino radical, a 1-N-1-4C-alkylamino-2-nitroethylene radical, an N-2-propynyl-N'-cyanoamidino radical, an aminosulfonylamidino radical, the radical -N(R10)R11, the part of the compound of formula (I) bonded to A (including X and via X), the glucopyranoside radical or a cyclic system or bicyclic system which is unsubstituted or substituted by R12 and R13 and which is selected from the group consisting of benzene, napththalene, furan, thiophene, pyrrole, oxazole, oxazoline, oxazolidinone, isoxazole, thiazole, thiazoline, isothiazole, imidazole, imidazoline, pyrazole, triazole, tetrazole, thiadiazole, thiadiazole 1-oxide, oxadiazole, pyridine, pyridine N-oxide, pyrimidine, halopyrimidine, piperidine, triazine, pyridone, benzimidazole, imidazopyridine, benzothiazole, benzoxazole, quinoline and imidazopyridazine, X is O (oxygen), N-1-4C-alkyl, NH or S, Y is O (oxygen), N-1-4C-alkyl, NH, S 1,4-piperazinylene or 1,4-piperidinylene, Z is O (oxygen), N-1-4C-alkyl, NH or S or CO, m is a number from 1 to 7, n is a number from 0 to 4, t is the number 0, 1 or 2 and u is the number 0 or 1, and their salts, are suitable for the control of Helicobacter bacteria.