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1.发明授权IVIG MODULATION OF CHEMOKINES FOR TREATMENT OF MULTIPLE SCLEROSIS, ALZHEIMER'S DISEASE, AND PARKINSON'S DISEASE 有权趋化因子的IVIG调制多发性硬化症的治疗，老年痴呆症和帕金森氏症
公开(公告)号：EP2191014B1
公开(公告)日：2013-04-03
申请号：EP08785488.1
申请日：2008-08-11
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
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2.发明授权RECOMBINANT VIRAL VECTORS AND METHODS FOR INDUCING A HETEROSUBTYPIC IMMUNE RESPONSE TO INFLUENZA A VIRUSES 有权重组病毒载体和方法引入HETEROSUBTYPISCHEN免疫反应甲型流感病毒
公开(公告)号：EP2670430B1
公开(公告)日：2015-04-01
申请号：EP12702162.4
申请日：2012-01-30
发明人： FALKNER, Falko-Günter , SCHÄFER, Birgit , HESSEL, Annett , BARRETT, P., Noel , KREIL, Thomas, R. , EHRLICH, Hartmut
IPC分类号： A61K39/145 , C07K14/11
CPC分类号： C12N15/86 , A61K39/12 , A61K39/145 , A61K39/285 , A61K2039/5256 , A61K2039/5258 , A61K2039/70 , C07K2319/00 , C12N7/00 , C12N15/62 , C12N2710/24122 , C12N2710/24123 , C12N2710/24134 , C12N2710/24143 , C12N2760/16134
摘要： The present invention relates to recombinant viral vectors and methods of using the recombinant viral vectors to induce an immune response to influenza A viruses. The invention provides recombinant viral vectors based, for example, on the non-replicating modified vaccinia virus Ankara. When administered according to methods of the invention, the recombinant viral vectors are designed to be cross-protective and induce heterosubtypic immunity to influenza A viruses.
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3.发明公开RECOMBINANT VIRAL VECTORS AND METHODS FOR INDUCING A HETEROSUBTYPIC IMMUNE RESPONSE TO INFLUENZA A VIRUSES 有权重组病毒载体和方法引入HETEROSUBTYPISCHEN免疫反应甲型流感病毒
公开(公告)号：EP2670430A2
公开(公告)日：2013-12-11
申请号：EP12702162.4
申请日：2012-01-30
发明人： FALKNER, Falko-Günter , SCHÄFER, Birgit , HESSEL, Annett , BARRETT, P., Noel , KREIL, Thomas, R. , EHRLICH, Hartmut
IPC分类号： A61K39/145 , C07K14/11
CPC分类号： C12N15/86 , A61K39/12 , A61K39/145 , A61K39/285 , A61K2039/5256 , A61K2039/5258 , A61K2039/70 , C07K2319/00 , C12N7/00 , C12N15/62 , C12N2710/24122 , C12N2710/24123 , C12N2710/24134 , C12N2710/24143 , C12N2760/16134
摘要： The present invention relates to recombinant viral vectors and methods of using the recombinant viral vectors to induce an immune response to influenza A viruses. The invention provides recombinant viral vectors based, for example, on the non-replicating modified vaccinia virus Ankara. When administered according to methods of the invention, the recombinant viral vectors are designed to be cross-protective and induce heterosubtypic immunity to influenza A viruses.
摘要翻译： 本发明涉及重组病毒载体以及使用该重组病毒载体，以诱导免疫应答以A型流感病毒对的方法。 本发明提供了基于重组病毒载体，例如，在非复制改良型痘苗病毒安卡拉。 当施用gemäß到本发明的方法中，重组病毒载体被设计为交叉保护性免疫，诱导异亚型A型流行性感冒病毒。
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4.发明公开IGG STIMULATED REMYELINATION OF PERIPHERAL NERVES 审中-公开IGG-STIMULIERTE REMYELINISIERUNG PERIPHERER NERVEN
公开(公告)号：EP2820042A2
公开(公告)日：2015-01-07
申请号：EP13709675.6
申请日：2013-02-28
发明人： KUERY, Patrick , TZEKOVA, Nevena , HARTUNG, Hans-peter , HERMANN, Corinna , REIPERT, Birgit Maria , SCHWARZ, Hans-peter , EHRLICH, Hartmut , BUNK, Sebastian
CPC分类号： C07K16/06 , A61K39/39516 , A61K45/06 , A61K2039/505 , C07K16/065 , A61K2300/00
摘要： The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.
摘要翻译： 本发明是基于多克隆IgG的促进雪旺氏细胞成熟，分化和髓鞘生成的能力的发现。 提供了通过施用多克隆IgG来治疗哺乳动物非特发性脱髓鞘外周神经病变的方法，其中神经病不是由免疫介导的或感染介导的。 可用本发明治疗的脱髓鞘周围神经病变的类型包括周围神经损伤和毒素诱导的周围神经病变。 或者，可以将多克隆IgG的组合物直接施用于周围神经细胞，以诱导成熟，分化成髓鞘状态和髓磷脂表达或促进细胞存活。
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5.发明授权
公开(公告)号：EP2257804B1
公开(公告)日：2013-12-11
申请号：EP09718006.1
申请日：2009-02-25
CPC分类号： G01N33/5014 , G01N33/5008 , G01N33/5058 , G01N33/6896 , G01N2333/4709 , G01N2500/10
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6.发明公开
公开(公告)号：EP2257804A1
公开(公告)日：2010-12-08
申请号：EP09718006.1
申请日：2009-02-25
CPC分类号： G01N33/5014 , G01N33/5008 , G01N33/5058 , G01N33/6896 , G01N2333/4709 , G01N2500/10
摘要： The present invention relates to a cell-based in vitro screening assay for identifying and selecting therapeutic agents that inhibit amyloid β-induced cytotoxicity.
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7.发明公开
公开(公告)号：EP2235188A2
公开(公告)日：2010-10-06
申请号：EP08870385.5
申请日：2008-12-30
发明人： SASGARY, Maria , SCHUSTER, Maria , SCHWARZ, Hans-Peter , REIPERT, Birgit , ANTOINE, Gerhard , EHRLICH, Hartmut
IPC分类号： C12N15/85 , A01K67/027 , C07K14/745 , C07K14/755 , A61K49/00 , G01N33/50 , C12N9/64
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/15 , A01K2227/105 , A01K2267/02 , A01K2267/03 , C07K14/745 , C07K14/755 , C12N9/64
摘要： The present invention relates, in general, to development of non-human transgenic animals expressing a human blood clotting factor, such as Factor VIII, Factor VII, Factor IX and von Willebrand factor. The invention further provides methods of detecting immunogenic events against human blood clotting factor using the transgenic animals described.
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8.发明公开IVIG MODULATION OF CHEMOKINES FOR TREATMENT OF MULTIPLE SCLEROSIS, ALZHEIMER'S DISEASE, AND PARKINSON'S DISEASE 有权趋化因子的IVIG调制多发性硬化症的治疗，老年痴呆症和帕金森氏症
公开(公告)号：EP2191014A2
公开(公告)日：2010-06-02
申请号：EP08785488.1
申请日：2008-08-11
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides methods for providing a prognosis of treatment of diseases associated with inflammatory disease of the brain, including MS, e.g., relapsing- remitting multiple sclerosis (RRMS), Alzheimer's disease, and Parkinson's disease using molecular markers that are shown to be overexpressed or underexpressed in patients treated with intravenous immunoglobulins (IVIG). Also provided are methods to identify compounds that are useful for the treatment or prevention of MS, e.g., relapsing-remitting multiple sclerosis (RRMS), Alzheimer's disease, and Parkinson's disease.
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9.发明公开FVIII PEPTIDES FOR IMMUNE TOLERANCE INDUCTION AND IMMUNODIAGNOSTICS 有权FVIII-PEPTIDE ZUR IMMUNTOLERANZINDUKTION UND IMMUNDIAGNOSTIK
公开(公告)号：EP2632479A1
公开(公告)日：2013-09-04
申请号：EP11796846.1
申请日：2011-10-27
发明人： STEINITZ, Katharina, Nora , WILHELMINA VAN HELDEN, Paula, Maria , REIPERT, Birgit, Maria , SCHWARZ, Hans-Peter , EHRLICH, Hartmut
IPC分类号： A61K38/37 , C07K14/755 , A61P7/04
CPC分类号： C07K14/755 , A61K38/37 , C07K2319/00 , C12P21/00 , G01N33/505 , G01N33/56977
摘要： The present invention is related to peptides that can be used to reduce the immune response against FVIII or to induce tolerance to human FVIII in patients with, e.g., hemophilia A. Furthermore, the peptides can be used for immunodiagnostic purposes to detect FVIII- specific CD4
+ T cells to monitor patients with hemophilia A during replacement therapy and during immune tolerance induction therapy.摘要翻译： 本发明涉及可用于减少针对FVIII的免疫应答或诱导对例如血友病A的患者对人FVIII的耐受性的肽。此外，该肽可用于免疫诊断目的以检测FVIII-特异性CD4 + T细胞在替代治疗期间和免疫耐受诱导治疗期间监测血友病A患者。
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公开(公告)号：EP2838561A1
公开(公告)日：2015-02-25
申请号：EP13728681.1
申请日：2013-04-16
IPC分类号： A61K39/395 , C07K16/24 , A61K31/7068 , A61K31/704 , A61K33/24 , A61K31/137 , A61P35/00
CPC分类号： A61K39/3955 , A61K31/136 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K2039/505 , A61K2039/545 , C07K16/24 , C07K2317/21 , C07K2317/76 , A61K2300/00
摘要： The present invention pertains to anti-MIF antibodies, in particular their use in combination with therapeutics, i.e. chemotherapeutics, in the treatment of cancer.
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