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1.发明公开VON WILLEBRAND FACTOR- AND FACTOR VIII-POLYMER CONJUGATES HAVING A RELEASABLE LINKAGE 有权血管性血友病因子和因子VIII WITH聚合物缀合物可分离的连接
公开(公告)号：EP2114458A2
公开(公告)日：2009-11-11
申请号：EP07868153.3
申请日：2007-12-27
发明人： BOSSARD, Mary, J. , STEPHENSON, Gayle , FANG, Zhihao , ZAPPE, Harold , MITCHELL, Stacy , ZHANG, Ping , SCHEIFLINGER, Friedrich , TURECEK, Peter , SIEKMANN, Juergen , VARADI, Katalin , GRITSCH, Herbert
CPC分类号： C07K14/755 , A61K47/60
摘要： The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
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2.发明授权VON WILLEBRAND FACTOR- AND FACTOR VIII-POLYMER CONJUGATES HAVING A RELEASABLE LINKAGE 有权血管性血友病因子和因子VIII WITH聚合物缀合物可分离的连接
公开(公告)号：EP2114458B1
公开(公告)日：2014-02-26
申请号：EP07868153.3
申请日：2007-12-27
发明人： BOSSARD, Mary, J. , STEPHENSON, Gayle , FANG, Zhihao , ZAPPE, Harold , MITCHELL, Stacy , ZHANG, Ping , SCHEIFLINGER, Friedrich , TURECEK, Peter , SIEKMANN, Juergen , VARADI, Katalin , GRITSCH, Herbert
IPC分类号： A61K47/48 , A61P7/00 , C07K14/755
CPC分类号： C07K14/755 , A61K47/60
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3.发明公开METHODS FOR DETERMINING ACTIVE INGREDIENTS IN PRO-DRUG PEG PROTEIN CONJUGATES WITH RELEASABLE PEG REAGENTS (IN VITRO DE-PEGYLATION) 审中-公开用于确定活性成分药物同可释放PEG试剂前体的PEG蛋白质结合物（体外DEPEGYLIERUNG）方法
公开(公告)号：EP2350658A2
公开(公告)日：2011-08-03
申请号：EP09752561.2
申请日：2009-10-20
发明人： VARADI, Katalin , SCHRENK, Gerald , ROTTENSTEINER, Hanspeter , TURECEK, Peter , WEBER, Alfred , ANDERLE, Heinz , CULBERTSON, Sean, M. , FANG, Zhihao , ZAPPE, Harold , ZHANG, Ping , BOSSARD, Mary, J.
IPC分类号： G01N33/542 , G01N33/58 , G01N33/68 , G01N33/86
CPC分类号： G01N33/68 , G01N33/542 , G01N33/582 , G01N33/86 , G01N2333/76
摘要： The invention relates to the development of in vitro assay systems that force the release of a water-soluble polymer, such as polyethylene glycol (PEG) and polysialic acid (PSA), from proteins modified with a reversibly-linked water-soluble polymer. The invention includes methods for analyzing the release of the water- soluble polymer and measuring regained protein activity. The invention further includes methods appropriate for the quality control of proteins modified with releasable water-soluble polymers, including polymers like PEG and PSA.
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公开(公告)号：EP2341942A1
公开(公告)日：2011-07-13
申请号：EP09789327.5
申请日：2009-09-17
申请人： Nektar Therapeutics
发明人： BOSSARD, Mary, J. , ROCZNIAK, Steven, O. , ZAPPE, Harold , WANG, Yujun , ZHANG, Ping , SHENG, Dawei , JUDE-FISHBURN, C., Simone , MINAMITANI, Elizabeth , LIU, Xiaofeng , MOSKOWITZ, Haim , FRY, Dennis , ALI, Cherie , BREW, Christine, Taylor
IPC分类号： A61K47/48
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
摘要翻译： 本发明提供了通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：EP1861125A2
公开(公告)日：2007-12-05
申请号：EP06739738.0
申请日：2006-03-23
发明人： BOSSARD, Mary J. , ZHANG, Ping
摘要： Conjugates of an hGH moiety and one or more non-peptidic water soluble polymers are provided. Typically, the non-peptidic water soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising such conjugates, methods of making the conjugates, and methods of administering compositions comprising such conjugates to a mammalian subject.
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公开(公告)号：EP2099495A2
公开(公告)日：2009-09-16
申请号：EP06800776.4
申请日：2006-08-04
发明人： BOSSARD, Mary, J. , ZHANG, Ping
IPC分类号： A61K47/48 , C07K14/535
CPC分类号： C07K14/535 , A61K47/60 , C07K14/53
摘要： Conjugates of a G-CSF moiety and one or more nonpeptidic water-soluble polymers are provided. Typically, the nonpeptidic water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions comprising conjugates to a patient.
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7.发明公开
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公开(公告)号：EP2340048A1
公开(公告)日：2011-07-06
申请号：EP09789343.2
申请日：2009-09-17
申请人： Nektar Therapeutics
CPC分类号： C07K5/1016 , A61K47/60
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
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公开(公告)号：EP2334333A1
公开(公告)日：2011-06-22
申请号：EP09789326.7
申请日：2009-09-17
申请人： Nektar Therapeutics
CPC分类号： C07K14/4723 , A61K47/60
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
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公开(公告)号：EP1768700B1
公开(公告)日：2010-12-15
申请号：EP05771041.0
申请日：2005-07-14
申请人： Nektar Therapeutics
发明人： BOSSARD, Mary, J. , ZHANG, Ping
CPC分类号： C07K14/535 , A61K38/00 , A61K47/60
摘要： Conjugates of a GM-CSF moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions comprising conjugates to a patient.
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