-
1.发明公开VON WILLEBRAND FACTOR- AND FACTOR VIII-POLYMER CONJUGATES HAVING A RELEASABLE LINKAGE 有权血管性血友病因子和因子VIII WITH聚合物缀合物可分离的连接
公开(公告)号：EP2114458A2
公开(公告)日：2009-11-11
申请号：EP07868153.3
申请日：2007-12-27
发明人： BOSSARD, Mary, J. , STEPHENSON, Gayle , FANG, Zhihao , ZAPPE, Harold , MITCHELL, Stacy , ZHANG, Ping , SCHEIFLINGER, Friedrich , TURECEK, Peter , SIEKMANN, Juergen , VARADI, Katalin , GRITSCH, Herbert
CPC分类号： C07K14/755 , A61K47/60
摘要： The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
-
2.发明授权VON WILLEBRAND FACTOR- AND FACTOR VIII-POLYMER CONJUGATES HAVING A RELEASABLE LINKAGE 有权血管性血友病因子和因子VIII WITH聚合物缀合物可分离的连接
公开(公告)号：EP2114458B1
公开(公告)日：2014-02-26
申请号：EP07868153.3
申请日：2007-12-27
发明人： BOSSARD, Mary, J. , STEPHENSON, Gayle , FANG, Zhihao , ZAPPE, Harold , MITCHELL, Stacy , ZHANG, Ping , SCHEIFLINGER, Friedrich , TURECEK, Peter , SIEKMANN, Juergen , VARADI, Katalin , GRITSCH, Herbert
IPC分类号： A61K47/48 , A61P7/00 , C07K14/755
CPC分类号： C07K14/755 , A61K47/60
-
公开(公告)号：EP2318050B1
公开(公告)日：2014-09-03
申请号：EP09790935.2
申请日：2009-07-29
发明人： TURECEK, Peter , SIEKMANN, Juergen
IPC分类号： A61K47/48 , C07K14/745
CPC分类号： A61K38/37 , A61K38/00 , A61K47/60 , A61K47/61 , C07K14/745
摘要： A composition comprising a conjugate comprising a native Factor VIII modified with a water soluble polymer bound thereto, said water soluble polymer attached to the modified Factor VIII via an oxidised carbohydrate moiety.
-
公开(公告)号：EP2459226A2
公开(公告)日：2012-06-06
申请号：EP10739386.0
申请日：2010-07-26
发明人： JAIN, Sanjay , GREGORIADIS, Gregory , DWIVEDI, Archana , NATH, Srijit , SIEKMANN, Juergen , HAIDER, Stefan , ROTTENSTEINER, Hanspeter , TURECEK, Peter
IPC分类号： A61K47/48
CPC分类号： A61K47/6455 , A61K47/60 , A61K47/61 , A61K47/65
摘要： A water soluble polymer, in particular polysialic acid (PSA) or a modified PSA (mPSA), is conjugated to an oxidized carbohydrate moiety of a glycoprotein other than a blood coagulation protein or to a ganglioside or drug delivery system by contacting the oxidized carbohydrate moiety with the water soluble polymer, wherein said water soluble polymer contains an aminooxy group and an oxime linkage is formed between the oxidized carbohydrate moiety and the aminooxy group on the water soluble polymer or wherein said water soluble polymer contains a hydrazide group and a hydrazone linkage is formed between the oxidized carbohydrate moiety and the hydrazide group on the water soluble polymer. Conjugates of aminooxy- or hydrazide-water soluble polymer, such as PSA and mPSA, are thus obtained in which the PSA or mPSA is attached via a carbohydrate moiety.
-
5.发明公开RECOMBINANT VON WILLIBRAND FACTOR AS A MOLECULAR WEIGHT MARKER FOR MASS SPECTROMETRY ANALYSES 有权重组血管性血友病因子分子量标准进行质量分析
公开(公告)号：EP2374004A1
公开(公告)日：2011-10-12
申请号：EP09771643.5
申请日：2009-12-16
发明人： KEMPTNER, Jasmin , MARCHETTI-DESCHMANN, Martina , MUELLER, Roland , IVENS, Andreas , TURECEK, Peter , SCHWARZ, Hans-Peter , ALLMAIER, Guenter
CPC分类号： G01N33/6851 , G01N2333/755 , H01J49/164
摘要： Methods for determining molecular mass of at least 150 kDa of an analyte of interest using MALDI mass spectrometry in combination with a recombinant von Willebrand factor (rVWF) molecular weight marker are disclosed. More specifically, monomeric and multimeric rVWF are used for external and internal calibration of mass spectra applied for analytes having high molecular weights above 150 kDa.
-
6.发明公开METHODS OF DETERMINING POLYDISPERSITY AND/OR MOLECULAR WEIGHT DISTRIBUTION OF A POLYETHYLENE GLYCOL SAMPLE 审中-公开法确定多分散性和/或聚乙二醇探头的分子量分布
公开(公告)号：EP2366105A1
公开(公告)日：2011-09-21
申请号：EP09760672.7
申请日：2009-11-18
发明人： KEMPTNER, Jasmin , MARCHETTI-DESCHMANN, Martina , SIEKMANN, Juergen , TURECEK, Peter , SCHWARZ, Hans-Peter , ALLMAIER, Guenter
IPC分类号： G01N33/68
CPC分类号： G01N27/624
摘要： Disclosed herein are methods of determining polydispersity (PDI) and molecular mass distribution (MMD) of reactive PEG samples using mass spectrometry. More specifically, a mass spectrometry method called GEMMA is used to determine PDI and MMD of PEG samples which provides more accurate measurements for high molecular weight PEG samples than prior known MALDI-TOF analysis.
-
7.发明公开METHODS OF MEASURING ADAMTS13-MEDIATED IN VIVO CLEAVAGE OF VON WILLEBRAND FACTOR AND USES THEREOF 有权值的测定方法ADAMTS13介导体内切割维勒布兰德因子及其用途
公开(公告)号：EP2358895A1
公开(公告)日：2011-08-24
申请号：EP09764426.4
申请日：2009-12-03
发明人： VARADI, Katalin , ROTTENSTEINER, Hanspeter , TURECEK, Peter , SCHWARZ, Hans-Peter , SCHREINER, Jutta
IPC分类号： C12Q1/37
CPC分类号： G01N33/86 , C12Q1/37 , C12Q1/56 , G01N33/573 , G01N2333/755 , G01N2333/96486 , G01N2800/224 , G01N2800/52
摘要： The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.
摘要翻译： 本发明基因的反弹涉及测量裂解von Willebrand因子（VWF）的片段的方法。 更具体地，本发明涉及到测量整合素和金属蛋白酶的具有血小板反应类型1基序的，构件13（ADAMTS13）切割VWF体内的能力的方法。 因此，本发明涉及使用多种动物模型的方法演示了类似于做了人体的哪个ADAMTS13活性。 本发明还涉及到测量的r的vWF的切割产物在哺乳动物，特别是在人类和在人血浆中的方法。
-
8.发明公开MODELS OF THROMBOTIC THROMBOCYTOPENIC PURPURA AND METHODS OF USE THEREOF 审中-公开VERFAHREN ZUR VEWENDUNG DAVON MODELLE TUVBOTISCH-THROMBOZYTOPENISCHE PURPURA
公开(公告)号：EP2350294A2
公开(公告)日：2011-08-03
申请号：EP09752581.0
申请日：2009-10-27
IPC分类号： C12N15/85 , A01K67/027 , A61K49/00
CPC分类号： A61K49/0008 , A01K67/027 , A01K67/0275 , A01K67/0276 , A01K2217/052 , A01K2217/054 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0325 , A01K2267/0381 , C12N15/8509
摘要： The invention relates to the development of an animal model for testing various agents in the treatment of a clotting disorder. More specifically, the invention relates to the use of ultra-large molecular weight multimers of von Willebrand factor (VWF) in various mouse strains to induce thrombotic thrombocytopenic purpura (TTP)-like symptoms for the development of a mouse model of TTP. The invention also provides methods for generating such animal disease models and screening methods for identifying biologically active compounds which are effective in the treatment of TTP.
摘要翻译： 本发明涉及用于测试治疗凝血障碍的各种药剂的动物模型的开发。 更具体地说，本发明涉及von Willebrand因子（VWF）的超大分子量多聚体在各种小鼠品系中的应用，以诱导血小板减少性紫癜（TTP）样症状，用于开发TTP小鼠模型。 本发明还提供了产生用于鉴定有效治疗TTP的生物活性化合物的这种动物疾病模型和筛选方法的方法。
-
">9.发明公开A KIT FOR MEASURING THE THROMBIN GENERATION IN A SAMPLE OF A PATIENT"S BLOOD OR PLASMA 有权KIT FOR测量凝血酶在血液或血浆样品的患者
公开(公告)号：EP1730299A2
公开(公告)日：2006-12-13
申请号：EP05729048.8
申请日：2005-03-30
发明人： VARADI, Katalin , TURECEK, Peter , KEIL, Brigitte , PEYRER-HEIMSTAETT, Sylvia , SCHWARZ, Hans-Peter
CPC分类号： A61K31/66 , C12Q1/56 , G01N33/86 , G01N2333/745
摘要： The invention provides a kit for measuring the thrombin generation in a sample of a patient's blood or plasma, or in a sample of clotting factors. The kit contains lyophilized tissue factor/phospholipid-complex and a lyophilized mixture containing a thrombin-substrate and CaCl2. The invention also provides processes for preparing the reagents for the kit. The kit can be used in a method for measuring the thrombin generation in a sample, wherein it is possible to detect changes in thrombin generation kinetics, for example after administration of inhibitor bypassing agents to a patient who has developed inhibitors to an exogenous clotting factor such as Factor VIII.
-
10.发明公开MATERIALS AND METHODS FOR CONJUGATING A WATER SOLUBLE FATTY ACID DERIVATIVE TO A PROTEIN 审中-公开材料和方法水溶性脂肪酸衍生物的蛋白质的共轭
公开(公告)号：EP2654794A1
公开(公告)日：2013-10-30
申请号：EP11806103.5
申请日：2011-12-16
摘要： The invention relates to materials and methods of conjugating a water soluble fatty acid derivative to a therapeutic protein comprising contacting the therapeutic protein with an activated water soluble fatty acid derivative under conditions that allow conjugation.
摘要翻译： 本发明涉及的材料和缀合的水溶性脂肪酸衍生物对治疗性蛋白，其包含与在活化的水溶性脂肪酸衍生物接触所述治疗性蛋白质的条件下确实允许缀合的方法。
-
-
-
-
-
-
-
-
-
搜索结果
47 条记录 (耗时 0.032 秒)
