公开(公告)号：EP1196392A1

公开(公告)日：2002-04-17

申请号：EP00945764.9

申请日：2000-06-16

申请人： Bayer Aktiengesellschaft

发明人： STOLTEFUSS, Jürgen ,  BRÄUNLICH, Gabriele ,  LÖGERS, Michael ,  SCHMECK, Carsten ,  NIELSCH, Ulrich ,  BECHEM, Martin ,  GERDES, Christian ,  SPERZEL, Michael ,  LUSTIG, Klemens ,  STÜRMER, Werner

IPC分类号： C07D237/04 ,  C07D401/10 ,  C07D409/12 ,  C07D401/12 ,  A61K31/50 ,  A61P7/06

CPC分类号： C07D401/10 ,  C07D237/04 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12

摘要： The invention relates to the area of erythropoiesis, in particular to substituted 6-carboxyphenyldihydropyridazinone derivatives of general formula (I), to methods for producing them and to their use as medicaments, preferably for preventing and/or treating anaemia.

摘要翻译： 本发明涉及红细胞生成的领域，具体涉及通式（I）的取代的6-羧基苯基二氢哒嗪酮衍生物，其制备方法及其作为药物的用途，优选用于预防和/或治疗贫血。

公开(公告)号：EP4001271A1

公开(公告)日：2022-05-25

申请号：EP20207246.8

申请日：2020-11-12

申请人： Bayer Aktiengesellschaft ,  Bayer Animal Health GmbH

发明人： REMBIAK, Andreas ,  OLENIK, Britta ,  KEIL, Birgit ,  DOCKNER, Michael ,  LÖGERS, Michael ,  MEHL, Benedikt

IPC分类号： C07D401/04 ,  A01N43/56

摘要： The present invention relates to a crystalline form A of 2-chloro-N-cyclopropyl-5-[1-[2,6-dichloro-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]pyrazol-4-yl]-N-methyl-pyridine-3-carboxamide (compound of formula (I)) and to the process of preparing the crystalline form A of the compound of formula (I).

公开(公告)号：EP1017692A1

公开(公告)日：2000-07-12

申请号：EP98948919.0

申请日：1998-09-07

申请人： Bayer Aktiengesellschaft

发明人： STOLTEFUSS, Jürgen ,  LÖGERS, Michael ,  SCHMIDT, Gunter ,  BRANDES, Arndt ,  SCHMECK, Carsten ,  BREMM, Klaus-Dieter ,  BISCHOFF, Hilmar ,  SCHMIDT, Delf

IPC分类号： C07D409/04 ,  A61K31/47 ,  C07D401/04 ,  C07D405/04 ,  C07D215/20 ,  C07F7/18

CPC分类号： C07D401/04 ,  C07D215/20 ,  C07D409/04

摘要： The invention concerns hetero-tetrahydroquinolines obtained either by corresponding condensation of heterotetrahydroquinolines aldehydes substituted, with the desired substituent, or by reduction of corresponding keto-substituted hetero-tetrahydroquinolines, then by introducing the desired substituents by the usual methods. Said hetero-tetrahydroquinolines are used as active principles, particularly in medicines for treating arterial sclerosis and dyslipemia.

公开(公告)号：EP1196173A2

公开(公告)日：2002-04-17

申请号：EP00947850.4

申请日：2000-06-16

申请人： Bayer Aktiengesellschaft

发明人： STOLTEFUSS, Jürgen ,  BRÄUNLICH, Gabriele ,  LÖGERS, Michael ,  SCHMECK, Carsten ,  NIELSCH, Ulrich ,  BECHEM, Martin ,  GERDES, Christian ,  SPERZEL, Michael ,  LUSTIG, Klemens ,  STÜRMER, Werner

IPC分类号： A61K31/549 ,  A61P7/06 ,  C07D417/04 ,  C07D417/14

CPC分类号： C07D417/04 ,  A61K31/549 ,  C07D417/14

摘要： The invention relates to the area of erythropoiesis, in particular to the use of tetrahydroquinolinyl-6-methyldihydrothiadiazinones of general formula (I) for preventing and/or treating anaemia. The invention also relates to novel tetrahydroquinolinyl-6-methyldihydrothiadiazinone derivatives and to the production thereof.

公开(公告)号：EP1272474A1

公开(公告)日：2003-01-08

申请号：EP01925339.2

申请日：2001-02-20

申请人： Bayer Aktiengesellschaft

发明人： BRÄUNLICH, Gabriele ,  LÖGERS, Michael ,  STOLTEFUSS , Jürgen ,  SCHMECK, Carsten ,  NIELSCH, Ulrich ,  STÜRMER, Werner ,  GERDES, Christoph ,  LUSTIG, Klemens ,  SPERZEL, Michael

IPC分类号： C07D237/04 ,  A61K31/50 ,  A61P7/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D401/12 ,  C07D237/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

摘要： The invention relates to the field of erythropoiesis and, in particular, relates to 5-methyldihydropyridazinones of general formula (I) and to the use thereof as medicaments, preferably for the prophylaxis of and/or for combating anemias.

公开(公告)号：EP1017677A1

公开(公告)日：2000-07-12

申请号：EP98948921.6

申请日：1998-09-07

申请人： Bayer Aktiengesellschaft

发明人： SCHMIDT, Gunter ,  STOLTEFUSS, Jürgen ,  LÖGERS, Michael ,  BRANDES, Arndt ,  SCHMECK, Carsten ,  BREMM, Klaus-Dieter ,  BISCHOFF, Hilmar ,  SCHMIDT, Delf

IPC分类号： C07D215/20 ,  A61K31/47 ,  C07D401/06 ,  C07D417/06

CPC分类号： C07D221/20 ,  C07D215/20 ,  C07D401/06 ,  C07D417/06

摘要： According to the invention, the tetrahydrochinoline can be produced in which corresponding substituted tetrahydrochinoline-aldehyde is condensed with suitable substances and afterwards the existing substituents are varied according to usual methods. The tetrahydrochinoline is suited for additives in medicaments, especially in medicaments for treating arteriosclerosis and dyslipidaemia.

摘要翻译： 根据本发明，可以制备四氢喹啉，其中相应的取代的四氢喹啉 - 醛与合适的物质缩合，然后根据常规方法改变现有的取代基。 四氢胆碱适用于药物中的添加剂，特别是用于治疗动脉硬化和血脂异常的药物中。

公开(公告)号：EP1017658A1

公开(公告)日：2000-07-12

申请号：EP98954266.7

申请日：1998-09-09

申请人： Bayer Aktiengesellschaft

发明人： LÖGERS, Michael ,  BRANDES, Arndt ,  SCHMIDT, Gunter ,  STOLTEFUSS, Jürgen ,  BREMM, Klaus-Dieter ,  BISCHOFF, Hilmar ,  SCHMIDT, Delf

IPC分类号： C07C33/50 ,  C07C33/46 ,  C07C43/178 ,  C07C69/78 ,  C07D309/12 ,  C07D213/64 ,  C07D211/88 ,  C07D207/404 ,  C07D209/48 ,  C07F7/08 ,  A61K31/045 ,  A61K31/075 ,  A61K31/695 ,  A61K31/35 ,  A61K31/40 ,  A61K31/44 ,  A61K31/45 ,  C07D207/40

CPC分类号： C07D209/48 ,  C07C33/46 ,  C07C33/486 ,  C07C33/50 ,  C07C43/1786 ,  C07C43/23 ,  C07C69/92 ,  C07C2601/02 ,  C07C2601/08 ,  C07D213/64 ,  C07D309/12

摘要： The invention relates to benzyl-biphenyls and analogous compounds thereof which are produced first by reacting α and β-unsaturated ketones to form corresponding substituted and conjugated dienes, and afterwards said dienes are cyclized with acetylene derivatives. The resulting cyclohexane dienes are oxidized to form aromatic compounds and/or are varied in available substituents through usual methods. The compounds are suited for additives in medicaments, especially in medicaments for treating arteriosclerosis and dyslipidaemia.

摘要翻译： 本发明涉及苄基联苯和类似化合物的其是通过使α和β不饱和酮，以形成对应substituiertem和共轭二烯，和后来说二烯是与乙炔衍生物的环化首先产生。 将得到的环己烷二烯烃是氧化形成的芳族化合物和/或在通过常规方法获得的取代基变化。 这些化合物在药物中适合的添加剂，特别是喜欢在药物用于治疗动脉硬化和血脂异常。