公开(公告)号：EP1150958A1

公开(公告)日：2001-11-07

申请号：EP00910605.5

申请日：2000-01-24

申请人： Bayer Aktiengesellschaft

发明人： STOLTEFUSS, Jürgen ,  BRÄUNLICH, Gabriele ,  HINZEN, Berthold ,  KRÄMER, Thomas ,  PERNERSTORFER, Josef ,  STÜDEMANN, Thomas ,  NIELSCH, Ulrich ,  BECHEM, Martin ,  LOHRMANN, Emanuel ,  GERDES, Christoph ,  SPERZEL, Michael ,  LUSTIG, Klemens ,  MAYR, Lorenz

IPC分类号： C07D231/12 ,  C07D409/04 ,  A61K31/415 ,  A61P7/06 ,  C07D401/04 ,  C07D405/04

CPC分类号： C07D231/12 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04

摘要： The invention relates to methods for the production of substituted pyrazole carboxylic acids of general formula (I). The key step is cyclization with hydrazines followed by saponification. The substituted pyrazole carboxylic acids are used as medicaments, especially as medicaments in the treatment and prophylaxis of anaemias.

公开(公告)号：EP1196173A2

公开(公告)日：2002-04-17

申请号：EP00947850.4

申请日：2000-06-16

申请人： Bayer Aktiengesellschaft

发明人： STOLTEFUSS, Jürgen ,  BRÄUNLICH, Gabriele ,  LÖGERS, Michael ,  SCHMECK, Carsten ,  NIELSCH, Ulrich ,  BECHEM, Martin ,  GERDES, Christian ,  SPERZEL, Michael ,  LUSTIG, Klemens ,  STÜRMER, Werner

IPC分类号： A61K31/549 ,  A61P7/06 ,  C07D417/04 ,  C07D417/14

CPC分类号： C07D417/04 ,  A61K31/549 ,  C07D417/14

摘要： The invention relates to the area of erythropoiesis, in particular to the use of tetrahydroquinolinyl-6-methyldihydrothiadiazinones of general formula (I) for preventing and/or treating anaemia. The invention also relates to novel tetrahydroquinolinyl-6-methyldihydrothiadiazinone derivatives and to the production thereof.

公开(公告)号：EP1272474A1

公开(公告)日：2003-01-08

申请号：EP01925339.2

申请日：2001-02-20

申请人： Bayer Aktiengesellschaft

发明人： BRÄUNLICH, Gabriele ,  LÖGERS, Michael ,  STOLTEFUSS , Jürgen ,  SCHMECK, Carsten ,  NIELSCH, Ulrich ,  STÜRMER, Werner ,  GERDES, Christoph ,  LUSTIG, Klemens ,  SPERZEL, Michael

IPC分类号： C07D237/04 ,  A61K31/50 ,  A61P7/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D401/12 ,  C07D237/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

摘要： The invention relates to the field of erythropoiesis and, in particular, relates to 5-methyldihydropyridazinones of general formula (I) and to the use thereof as medicaments, preferably for the prophylaxis of and/or for combating anemias.

公开(公告)号：EP1196392A1

公开(公告)日：2002-04-17

申请号：EP00945764.9

申请日：2000-06-16

申请人： Bayer Aktiengesellschaft

发明人： STOLTEFUSS, Jürgen ,  BRÄUNLICH, Gabriele ,  LÖGERS, Michael ,  SCHMECK, Carsten ,  NIELSCH, Ulrich ,  BECHEM, Martin ,  GERDES, Christian ,  SPERZEL, Michael ,  LUSTIG, Klemens ,  STÜRMER, Werner

IPC分类号： C07D237/04 ,  C07D401/10 ,  C07D409/12 ,  C07D401/12 ,  A61K31/50 ,  A61P7/06

CPC分类号： C07D401/10 ,  C07D237/04 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12

摘要： The invention relates to the area of erythropoiesis, in particular to substituted 6-carboxyphenyldihydropyridazinone derivatives of general formula (I), to methods for producing them and to their use as medicaments, preferably for preventing and/or treating anaemia.

摘要翻译： 本发明涉及红细胞生成的领域，具体涉及通式（I）的取代的6-羧基苯基二氢哒嗪酮衍生物，其制备方法及其作为药物的用途，优选用于预防和/或治疗贫血。

公开(公告)号：EP1148879A2

公开(公告)日：2001-10-31

申请号：EP00909096.0

申请日：2000-01-24

申请人： Bayer Aktiengesellschaft

发明人： STOLTEFUSS, Jürgen ,  BRÄUNLICH, Gabriele ,  HINZEN, Berthold ,  KRÄMER, Thomas ,  PERNERSTORFER, Josef ,  STÜDEMANN, Thomas ,  NIELSCH, Ulrich ,  BECHEM, Martin ,  LOHRMANN, Emanuel ,  GERDES, Christoph ,  SPERZEL, Michael ,  LUSTIG, Klemens ,  MAYR, Lorenz

IPC分类号： A61K31/4155 ,  A61K31/443 ,  A61P7/06 ,  C07D231/12

CPC分类号： C07D231/12 ,  A61K31/415 ,  C07D401/04 ,  C07D409/04

摘要： The present invention relates to novel and known pyrazole carboxamides of general formulae (I and Ia), whereby A, A', D, D', E, E', G, G', R1, R'1, R2 and L have the meaning as given in the description. The invention also relates to the production of pyrazole carboxamides by means of solid phase chemistry or novel pyrazole carboxamides. The pyrazole carboxamides are used as medicaments, especially (oral) medicaments for the treatment of anaemias. Said carboxamides stimulate the EPO production (erythropoesis) and can be used with own blood donors.