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公开(公告)号：EP2720539A1
公开(公告)日：2014-04-23
申请号：EP12800198.9
申请日：2012-06-13
发明人： GARVEY, David, S.
IPC分类号： A01N35/00
CPC分类号： C07D333/22 , A61K31/045 , A61K31/12 , A61K31/277 , C07C25/06 , C07C25/13 , C07C25/18 , C07C33/14 , C07C33/34 , C07C33/50 , C07C43/23 , C07C49/792 , C07C49/813 , C07C49/84 , C07C255/53 , C07C255/56 , C07C259/18 , C07C2601/14 , C07C2601/16 , C07D307/42 , C07D307/46 , C07D333/16
摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
摘要翻译： 公开了用于治疗由眼部积聚的有毒视觉周期产物引起的或与眼部产生有关的眼科病症的化合物，例如干性成人黄斑变性，以及由突变视蛋白错误折叠引起的或与错误折叠相关的病症和 /或视蛋白蛋白的错误定位。 还描述了单独或与其他治疗剂组合的这些化合物的组合物以及使用这些化合物和/或组合物的治疗方法。 还公开了合成这些试剂的方法。
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2.发明公开BUTENOL-TRIAZOLYL DERIVATE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS MIKROBIZIDE 失效丁烯醇三唑衍生物，其制备及其作为杀菌剂
公开(公告)号：EP0719260A1
公开(公告)日：1996-07-03
申请号：EP94928316.0
申请日：1994-09-06
申请人： BAYER AG
IPC分类号： A01N43 , C07C29 , C07C33 , C07C45 , C07C49 , C07C201 , C07C205 , C07D249 , C07D303 , C07D521
CPC分类号： C07D249/08 , A01N43/653 , C07C33/50 , C07C45/68 , C07C45/75 , C07C49/567 , C07D231/12 , C07D233/56 , C07D303/08
摘要： Novel hydroxy ethyl azolyl derivatives of formula (I), in which: X is hydrogen, halogen, alkyl with 1 to 4 carbon atoms or alkoxy with 1 to 4 carbon atoms; Z is halogen, alkyl with 1 to 4 carbon atoms, halogen alkyl with 1 to 4 carbon atoms and 1 to 5 halogen atoms, alkoxy with 1 to 4 carbon atoms, halogen alkoxy with 1 to 4 carbon atoms and 1 to 5 halogen atoms, nitro or possibly singly to triply, identically or differently halogen-substituted phenyl; and m is the number 0, 1, 2 or 3; and their acid-addition salts and metal salt complexes, a process for producing the novel materials and their use as microbicides in plant and material protection. Novel butenol derivatives of formula (II), novel oxiranes of formula (III) and novel ketones of formula (X) are also disclosed, together with methods for their manufacture and their use as intermediates in the synthesis of compounds of formula (I).
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3.发明授权Azolylmethylcycloalkane, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel 失效氨基甲基纤维素，其制备方法及其治疗用途
公开(公告)号：EP0121081B1
公开(公告)日：1991-01-30
申请号：EP84101905.2
申请日：1984-02-23
发明人： Janssen, Bernd, Dr. , Meyer, Norbert, Dr. , Pommer, Ernst-Heinrich, Dr. , Ammermann, Eberhard, Dr. , Kohlmann, Friedrich-Wilhelm, Dr. , Wesenberg, Walter , Heberle, Wolfgang, Dr.
IPC分类号： C07D249/08 , C07D233/58 , C07D233/60 , C07D405/08 , C07D401/08 , C07D409/08 , A61K31/41 , A61K31/415 , A01N43/64 , A01N43/50
CPC分类号： C07D231/12 , A01N43/50 , A01N43/653 , B27K3/343 , C07C29/14 , C07C45/44 , C07C47/457 , C07C255/00 , C07C309/00 , C07C2601/12 , C07D233/56 , C07D249/08 , C07C33/50
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4.发明公开
公开(公告)号：EP0347690A3
公开(公告)日：1990-03-28
申请号：EP89110558.7
申请日：1989-06-10
发明人： Hermeling, Dieter, Dr. , Degner, Dieter, Dr. , Harreus, Albrecht, Dr. , Goetz, Norbert, Dr. , Wild, Jochen, Dr. , Theobald, Hans, Dr. , Wolf, Bernd, Dr.
IPC分类号： C25B3/02 , C07C33/46 , C07C69/025
摘要： Verfahren zur Herstellung von Benzolderivaten der allgemeinen Formel
in der Hal ein Halogenatom, R¹ einen Kohlenwasserstoffrest mit 1 bis 18 C-Atomen, R² ein Wasserstoffatom oder einen Alkylrest mit 1 bis 6 C-Atomen und X ein Wasserstoff- oder Halogenatom bedeuten, bei dem man Toluolderivate der allgemeinen Formel
in Gegenwart einer Säure der Formel R²-COOH (III) elektrochemisch oxidiert, sowie neue Benzolderivate der allgemeinen Formel
in der R³ ein Wasserstoffatom oder einen R²-CO-Rest bedeutet, wobei jedoch R¹ nicht Methyl sein kann, wenn X Wasserstoff bedeutet, und neue Benzolderivate der allgemeinen Formel
in der R⁴ einen verzweigten oder ringförmigen Alkylrest mit 3 bis 12 C-Atomen bedeutet, wobei jedoch R⁴ nicht Isopropyl sein kann, wenn X Wasserstoff bedeutet.-
公开(公告)号：EP0135177B1
公开(公告)日：1989-12-06
申请号：EP84110139.7
申请日：1984-08-24
IPC分类号： C07D233/56 , C07D277/30 , C07D213/55 , A61K31/415 , A61K31/425 , A61K31/44
CPC分类号： C07D231/12 , C07C33/34 , C07C33/50 , C07C57/62 , C07C62/36 , C07D213/55 , C07D233/56 , C07D233/84 , C07D249/08 , C07D277/30 , C07D277/40
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6.发明公开Liquidcrystalline cyclohexylbenzene derivatives their manufacturing and novel nematic admixtures containing same 失效液体环己烷衍生物他们的制造和新的含有相似物质的物质
公开(公告)号：EP0272580A3
公开(公告)日：1989-05-24
申请号：EP87118518.7
申请日：1987-12-14
IPC分类号： C09K19/30 , C07C69/74 , C07C205/06 , C07C49/813 , C07C25/18 , C07C211/00 , C07C331/28
CPC分类号： C07C205/19 , C07C22/04 , C07C33/50 , C07C49/813 , C07C205/06 , C07C205/11 , C07C205/42 , C07C205/45 , C07C205/55 , C07C205/56 , C07C331/28 , C07C2601/14 , C09K19/3001 , C09K2019/0444
摘要： New compounds of the general formula I:
wherein R¹ is a normal or branched alkyl chain H 2n+1 C n - or a normal or branched alkoxy group H 2n+1 C n O-, n being an integer number from 1 to 12; X is a bridging group from the set: -COO-, -OCO-, -CH₂O-, -OCH₂-, -COCH₂-, -CHOHCH₂-, -CH=CH-,-CH₂CH₂-, -CHClCH₂-, -CHCNCH₂-, -CHBrCH₂-, -CHFCH₂-, -CHOCH₃CH₂-; Y is a terminal group from the set: -NO₂, -NH₂, -NCS, -Cl, -Br, -F; the cyclohexane rings are trans-1,4-disubstituted ones and the benzene rings are 1,4-disubstituted ones, and besides one of them may contain sometimes additionally a fluorine atom in position 2 or 3, k and l are integer numbers from the set: 0, 1, 2 fulfilling the condition that k+1=2 or 3; besides, if X denotes the -COO- or -OCO- group, then k+1 also may assume the value of 1 , their manufacture and liquid crystalline admixture containing them and use for electro-optical devices as dielectrics are described.摘要翻译： 新的通式I化合物：其中R 1是正链或支链烷基链H 2n + 1Cn-或正构或支链烷氧基H 2n + C n O O-，n是1至12的整数; X是一个由-COO - ， - OCO - ， - CH 2 O-，-OCH 2 - ， - COCH 2 - ， - CHOHCH 2 - ， - CH = CH - ， - CH 2 CH 2 - ， - CHClCH 2 - ， - ，-CHBrCH 2 - ， - CHFCH 2 - ， - CHOCH 3 CH 2 - ; Y是以下基团的末端基团：-NO 2，-NH 2，-NCS，-Cl，-Br，-F; 环己烷环是反式-1,4-二取代的，苯环是1,4-二取代的环，其中一个可能有时另外含有位置2或3的氟原子，k和l是从 设定：0,1,2满足k + 1 = 2或3的条件; 此外，如果X表示-COO-或-OCO-基团，则k + 1也可以取值为1，其制造和含有它们的液晶混合物用作电光装置作为电介质。
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公开(公告)号：EP0154528A2
公开(公告)日：1985-09-11
申请号：EP85301414.0
申请日：1985-03-01
IPC分类号： C07C49/248 , C07C33/48 , C07C255/49 , C07C255/37 , C07C317/00 , C07D521/00 , A61K31/33 , A61K31/10 , A61K31/12 , A61K31/275
CPC分类号： C07C17/23 , C07C17/278 , C07C33/483 , C07C33/50 , C07C45/26 , C07C45/54 , C07C45/72 , C07C45/74 , C07C47/273 , C07C49/235 , C07C49/245 , C07C49/248 , C07C59/56 , C07C205/26 , C07C205/45 , C07C255/00 , C07C317/00 , C07C323/00 , C07D213/34 , C07D213/57 , C07D213/61 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/36 , C07D219/04 , C07D233/84 , C07D239/38 , C07D239/47 , C07D239/56 , C07D249/12 , C07D251/38 , C07D277/24 , C07D277/36 , C07D303/08 , C07D333/28 , C07D333/38 , C07D333/44 , C07D339/06 , C07D473/24 , C07D473/38 , C07D487/04 , C07F7/0818 , C07C25/18
摘要： A compound of the formula
wherein X has the formula
wherein ring A is phenyl, naphthyl or heterocyclic; wherein R' is hydrogen, alkyl, alkanoyl or aroyl; wherein R 2 , R 3 and R 4 , which may be the same or different, each is an electron withdrawing substituent selected from halogeno, nitro, cyano, trifluoromethyl, alkylthio, alkylsulphinyl and alkylsulphonyl or each is hydrogen, alkyl, alkoxy or dialkylamino provided that when ring A is phenyl or naphthyl at least one of R 2 , R 3 and R 4 is an electron-withdrawing substituent; wherein R 5 and R 6 , which may be the same or different, each is hydrogen, halogeno or alkyl; wherein R 7 is alkyl or halogenoalkyl; and wherein R S is carbamoyl, alkyl, cycloalkyl, alkenyl, alkynyl, halogenoalkyl, halogenoalkenyl, halogenoalkynyl, alkanoyl, alkylcarbamoyl, dialkylcarbamoyl or aroyl; or wherein R 8 is alkyl or alkenyl which bears one or more substituents selected from cyano, carbamoyl, amino, hydroxy, alkanoyl, alkoxy, alkylthio, alkenylthio, alkylsulphinyl, alkenylsulphinyl, alkylsulphonyl, alkenylsulphonyl, alkanoylamino, alkoxycarbonylamino, alkylsulphonamido, alkylamino, dialkylamino dialkylsulphamoyl, aroyl, aryl, arylthio, arylsulphinyl, arylsulphonyl, heterocyclylthio, heterocyclylsulphinyl and heterocyclylsulphonyl; or wherein R 8 has the formula
wherein ring B is phenyl, naphthyl or heterocyclyl and wherein R 2 , R 3 and R 4 have any of the meanings stated above, provided that when R 7 is methyl R 8 is not also methyl.-
8.发明公开Lower cycloalkyl substituted-benzene derivatives, the preparation thereof and their pharmaceutical compositions 失效低环己基取代苯并噻吩衍生物，其制备方法及其药物组合物
公开(公告)号：EP0000644A3
公开(公告)日：1979-09-19
申请号：EP78300168
申请日：1978-07-19
发明人： Kamiya, Takashi , Shiokawa, Youichi
IPC分类号： C07C65/20 , C07C101/18 , C07C143/74 , C07C143/822 , C07C91/16 , C07C101/04 , A61K31/00 , C07C69/76 , C07C65/14 , C07C31/34 , C07C43/12 , C07C63/60 , C07C59/22 , C07D317/30 , C07D317/18
CPC分类号： C07D213/80 , C07C29/14 , C07C33/50 , C07C41/16 , C07C41/18 , C07C41/26 , C07C43/168 , C07C43/1788 , C07C45/59 , C07C49/252 , C07C57/48 , C07C59/56 , C07C59/72 , C07C69/734 , C07C309/73 , C07C311/04 , C07C2601/14 , C07D295/145 , C07D317/30
摘要： Lower cycloalkyl substituted-benzene derivatives, the preparation thereof and their pharmaceutical compositions. Lower cycloalkyl substituted-benzene derivatives of the formula:-
wherein R' is lower cycloalkyl, R 2 is carboxy, esterified carboxy, hydroxymethyl, lower alkoxymethyl or acyloxymethyl, R 3 is lower alkanoyl or lower alkyl substituted with hydroxy, amino, lower alkylamino, di(lower)alkylamino, acylamino, lower alkoxy, acyl or acyloxy, in which the lower alkyl moieties of the di(lower)alkyl amino radical may be joined together to form a heterocyclic ring containing the nitrogen atom and the carbonyl function of the acyl radical, which is a substituent on the lower alkyl radical, may be protected, X is hydrogen or halogen, and Y is a valency bond or lower alkylene;
and pharmaceutically acceptable salts thereof;
pharmaceutical composition comprising the same; and methods for treatment of inflammation by administering the same to mammals.摘要翻译： 其中R 1为低级环烷基，R 2为羧基，酯化羧基，羟甲基，低级烷氧基甲基或酰氧基甲基，R 3为低级烷酰基或低级烷基 被羟基，氨基，低级烷基氨基，二（低级）烷基氨基，酰基氨基，低级烷氧基，酰基或酰氧基取代，其中二（低级）烷基氨基的低级烷基部分可以连接在一起形成含有 氮原子和作为低级烷基上的取代基的酰基的羰基功能可以被保护，X是氢或卤素，Y是价键或低级亚烷基; 及其药学上可接受的盐; 包含其的药物组合物; 以及通过将其施用于哺乳动物来治疗炎症的方法。
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9.发明公开Lower cycloalkyl substituted-benzene derivatives, the preparation thereof and their pharmaceutical compositions 失效与低级环烷基取代的苯衍生物，其制备方法和它们的药物组合物。
公开(公告)号：EP0000644A2
公开(公告)日：1979-02-07
申请号：EP78300168.8
申请日：1978-07-19
发明人： Kamiya, Takashi , Shiokawa, Youichi
IPC分类号： C07C65/20 , C07C101/18 , C07C143/74 , C07C143/822 , C07C91/16 , C07C101/04 , A61K31/00 , C07C69/76 , C07C65/14 , C07C31/34 , C07C43/12
CPC分类号： C07D213/80 , C07C29/14 , C07C33/50 , C07C41/16 , C07C41/18 , C07C41/26 , C07C43/168 , C07C43/1788 , C07C45/59 , C07C49/252 , C07C57/48 , C07C59/56 , C07C59/72 , C07C69/734 , C07C309/73 , C07C311/04 , C07C2601/14 , C07D295/145 , C07D317/30
摘要： Lower cycloalkyl substituted-benzene derivatives, the preparation thereof and their pharmaceutical compositions.
Lower cycloalkyl substituted-benzene derivatives of the formula:-
wherein R' is lower cycloalkyl,
R 2 is carboxy, esterified carboxy, hydroxymethyl, lower alkoxymethyl or acyloxymethyl,
R 3 is lower alkanoyl or lower alkyl substituted with hydroxy, amino, lower alkylamino, di(lower)alkylamino, acylamino, lower alkoxy, acyl or acyloxy, in which the lower alkyl moieties of the di(lower)alkyl amino radical may be joined together to form a heterocyclic ring containing the nitrogen atom and the carbonyl function of the acyl radical, which is a substituent on the lower alkyl radical, may be protected,
X is hydrogen or halogen, and
Y is a valency bond or lower alkylene;
and pharmaceutically acceptable salts thereof;
pharmaceutical composition comprising the same; and methods for treatment of inflammation by administering the same to mammals.摘要翻译： 式的低级环烷基substituiertem - 苯衍生物： -
worin - [R <1>是低级环烷基，R <2>是羧基，酯化的羧基，羟甲基，低级烷氧基甲基或酰氧基甲基，R <3>是低级链烷酰基或低级烷基 被羟基，氨基，低级烷基氨基，二substituiertem（低级）烷基氨基，酰氨基，低级烷氧基，酰基或酰氧基，其中，二（低级）烷基氨基的基团，低级烷基部分可被连接在一起以形成杂环包含的 氮原子，酰基基团，所有这些是在基团的低级烷基的取代基的羰基官能团，可以被保护，X为氢或卤素，Y是价键或亚烷基低; 以及它们的药学上可接受的盐; 药物组合物，其包含相同的; 并给予该哺乳动物治疗炎症的方法。 -
10.发明公开CATALYSTS FOR EFFICIENT Z-SELECTIVE METATHESIS 审中-公开KATALYSATOREN ZUR EFFIZIENTEN Z-SELEKTIVEN METATHESE
公开(公告)号：EP3008078A4
公开(公告)日：2017-02-08
申请号：EP14811197
申请日：2014-06-12
CPC分类号： C07D333/56 , B01J31/226 , B01J31/2273 , B01J31/2278 , B01J2231/543 , B01J2531/821 , C07B37/08 , C07B2200/09 , C07C6/06 , C07C29/32 , C07C41/30 , C07C45/68 , C07C51/353 , C07C231/12 , C07C2601/08 , C07C2601/14 , C07D209/12 , C07F5/025 , C07F7/0818 , C07F15/0046 , C08G61/08 , C08G2261/3324 , C08G2261/418 , C07C235/30 , C07C33/38 , C07C33/50 , C07C43/23 , C07C43/166 , C07C33/30 , C07C33/025 , C07C47/263 , C07C33/02 , C07C59/42 , C07C43/178 , C07C49/835 , C07C33/14 , C07C33/483 , C07C43/176 , C07C33/12 , C07C43/162 , C07C13/28
摘要： The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, provided compounds promote highly efficient and highly Z-selective metathesis. In some embodiments, provided compounds and methods are particularly useful for producing allyl alcohols. In some embodiments, provided compounds have the structure of formula I. In some embodiments, provided compounds comprise ruthenium, and a ligand bonded to ruthenium through a sulfur atom.
摘要翻译： 本申请尤其提供了复分解反应的化合物和方法。 在一些实施方案中，所提供的化合物促进高效和高度Z选择性复分解。 在一些实施方案中，所提供的化合物和方法特别可用于生产烯丙醇。 在一些实施方案中，所提供的化合物具有式I的结构。在一些实施方案中，所提供的化合物包含钌和通过硫原子与钌键合的配体。
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