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公开(公告)号：EP3526212A1
公开(公告)日：2019-08-21
申请号：EP17780751.8
申请日：2017-10-09
发明人： GIESE, Anja , KLAR, Jürgen , EHRMANN, Alexander Helmut Michael , WILLWACHER, Jens , ENGEL, David , DIESKAU, Andre Philippe , KAHNERT, Antje , GROMOV, Alexey , SCHMECK, Carsten , LINDNER, Niels , MÜLLER, Thomas , ANDREEVSKI, Anna Lena , DREHER, Jan , COLLINS, Karl
IPC分类号： C07D403/14 , C07D471/04 , C07D487/04 , C07D413/14 , A61K31/506 , A61K31/5377 , A61P13/12
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2.发明授权SUBSTITUIERTE PYRAZOLO[1,5-A]PYRIDIN-3-CARBOXAMIDE UND IHRE VERWENDUNG 有权SUBSTITUIERTE吡唑[1,5-A]吡啶-3-甲酰胺和IHRE VERWENDUNG
公开(公告)号：EP3030562B1
公开(公告)日：2017-07-26
申请号：EP14749778.8
申请日：2014-08-05
发明人： VAKALOPOULOS, Alexandros , FOLLMANN, Markus , BUCHGRABER, Philipp , GROMOV, Alexey , HARTUNG, Ingo , LINDNER, Niels , WUNDER, Frank , STASCH, Johannes-Peter , MARQUARDT, Tobias , REDLICH, Gorden , DIETZ, Lisa , LI, Volkhart Min-Jian
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D519/00
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公开(公告)号：EP3004094A1
公开(公告)日：2016-04-13
申请号：EP14727828.7
申请日：2014-06-04
发明人： VAKALOPOULOS, Alexandros , FOLLMANN, Markus , HARTUNG, Ingo , BUCHGRABER, Philipp , GROMOV, Alexey , LINDNER, Niels , WUNDER, Frank , STASCH, Johannes-Peter , REDLICH, Gorden , LI, Volkhart Min-Jian
IPC分类号： C07D471/04 , A61K31/437 , A61P7/02 , A61P9/04 , A61P9/12 , A61P9/10
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
摘要： The invention relates to novel 3-aryl-substituted imidazo[1,2-a]pyridines, to a method for producing same, to the use thereof individually or in combinations for the treatment and/or prophylaxis of diseases, and to the use thereof for producing medication for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
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公开(公告)号：EP3107920B1
公开(公告)日：2017-10-18
申请号：EP15706404.9
申请日：2015-02-17
发明人： VAKALOPOULOS, Alexandros , GROMOV, Alexey , FOLLMANN, Markus , BROCKSCHNIEDER, Damian , STASCH, Johannes-Peter , MARQUARDT, Tobias , TERSTEEGEN, Adrian , WUNDER, Frank , REDLICH, Gorden , LANG, Dieter , LI, Volkhart Min-Jian
IPC分类号： C07D519/00 , A61K31/519 , A61P9/00
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06
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公开(公告)号：EP3107920A1
公开(公告)日：2016-12-28
申请号：EP15706404.9
申请日：2015-02-17
发明人： VAKALOPOULOS, Alexandros , GROMOV, Alexey , FOLLMANN, Markus , BROCKSCHNIEDER, Damian , STASCH, Johannes-Peter , MARQUARDT, Tobias , TERSTEEGEN, Adrian , WUNDER, Frank , REDLICH, Gorden , LANG, Dieter , LI, Volkhart Min-Jian
IPC分类号： C07D519/00 , A61K31/519 , A61P9/00
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06
摘要： The application relates to novel 3-(pyrimidine-2-yl) imidazo[1,2-a]pyridines of formula (I), methods for producing same, the use thereof alone or in combinations for treating and/or preventing diseases, and the use thereof for producing medicaments for treating and/or preventing diseases, in particular for treating and/or preventing cardiovascular diseases.
摘要翻译： 本申请涉及新颖的3-（嘧啶-2-基）咪唑并[1,2-a]吡啶，其制备方法单独或组合用于治疗和/或预防疾病 以及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病的药物。
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6.发明公开CARBOXY-SUBSTITUIERTE IMIDAZO[1,2-A]PYRIDINCARBOXAMIDE UND IHRE VERWENDUNG ALS STIMULATOREN DER LÖSLICHEN GUANYLATCYCLASE 审中-公开羧基取代的咪唑并[1,2-A]吡啶甲酰胺及其作为可溶性鸟苷酸环化酶的刺激
公开(公告)号：EP2914595A1
公开(公告)日：2015-09-09
申请号：EP13786229.8
申请日：2013-11-04
发明人： VAKALOPOULOS, Alexandros , HARTUNG, Ingo , FOLLMANN, Markus , JAUTELAT, Rolf , GROMOV, Alexey , LINDNER, Niels , SCHNEIDER, Dirk , WUNDER, Frank , STASCH, Johannes-Peter , REDLICH, Gorden , LI, Volkhart Min-Jian
IPC分类号： C07D471/04 , A61K31/437 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/12
CPC分类号： C07D401/10 , A61K31/4353 , A61K31/437 , A61K45/06 , C07D401/02 , C07D471/04
摘要： The invention relates to novel substituted imidazo[1,2-a]pyridino-3-carboxamides of formula (I) in which R
3 is a group of the formula, to methods for their production, their use alone or in combination for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular diseases.-
7.发明授权3-ARYL-SUBSTITUIERTE IMIDAZO[1,2-A]PYRIDINE UND IHRE VERWENDUNG 有权3-ARYL-SUBSTITUIERTE IMIDAZO [1,2-A] PYRIDINE UND IHRE VERWENDUNG
公开(公告)号：EP3004094B1
公开(公告)日：2017-03-01
申请号：EP14727828.7
申请日：2014-06-04
发明人： VAKALOPOULOS, Alexandros , FOLLMANN, Markus , HARTUNG, Ingo , BUCHGRABER, Philipp , GROMOV, Alexey , LINDNER, Niels , WUNDER, Frank , STASCH, Johannes-Peter , REDLICH, Gorden , LI, Volkhart Min-Jian
IPC分类号： C07D471/04 , A61K31/437 , A61P7/02 , A61P9/04 , A61P9/12 , A61P9/10
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
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8.发明公开
公开(公告)号：EP3046911A1
公开(公告)日：2016-07-27
申请号：EP14771828.2
申请日：2014-09-12
发明人： STRAUB, Alexander , COLLIN, Marie-Pierre , KOCH, Michael , MEYER, Jutta , SCHLEMMER, Karl-Heinz , NISING, Carl Friedrich , BIBER, Nicole , ANLAUF, Sonja , GROMOV, Alexey , WITTWER, Matthias Beat
IPC分类号： C07D239/36 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D409/06 , C07D409/04 , C07D411/04 , C07D413/04 , A61K31/513 , A61P9/00
CPC分类号： C07D401/04 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K45/06 , C07D239/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D411/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D471/04
摘要： The invention relates to novel heterocyclic substituted 6-(trifluoromethyl)pyrimidine- 4(3H)-one derivatives, to a method for the production thereof, to the use thereof either alone or in combination for the treatment and/or prevention of diseases, and to the use thereof for producing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular, renal, inflammatory and fibrotic diseases.
摘要翻译： 本申请涉及新的杂环取代的6-（三氟甲基）嘧啶-4（3H） - 酮衍生物，其制备方法单独使用或组合用于治疗和/或预防疾病及其用途 用于制备用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管，肾，炎症和纤维化疾病的药物。
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9.发明公开SUBSTITUIERTE PYRAZOLO[1,5-A]PYRIDIN-3-CARBOXAMIDE UND IHRE VERWENDUNG 有权替加利西亚PYRAZOLO [1,5-A] PYRIDIN-3-CARBOXAMIDE UND IHRE VERWENDUNG
公开(公告)号：EP3030562A1
公开(公告)日：2016-06-15
申请号：EP14749778.8
申请日：2014-08-05
发明人： VAKALOPOULOS, Alexandros , FOLLMANN, Markus , BUCHGRABER, Philipp , GROMOV, Alexey , HARTUNG, Ingo , LINDNER, Niels , WUNDER, Frank , STASCH, Johannes-Peter , MARQUARDT, Tobias , REDLICH, Gorden , DIETZ, Lisa , LI, Volkhart Min-Jian
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D519/00
摘要： The invention relates to a new type of substituted pyrazolo[1,5-a]-pyridine-3-carboxamides, to a method for producing same, to the use thereof alone or in combinations for treating and/or preventing diseases and to the use thereof for producing medicaments for treating and/or preventing diseases, in particular for treating and/or preventing cardiovascular diseases.
摘要翻译： 本申请涉及新颖的吡唑并[1,5-a]吡啶-3-甲酰胺，其制备方法，单独或组合用于治疗和/或预防疾病的用途及其用途 用于生产用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：EP3019506A1
公开(公告)日：2016-05-18
申请号：EP14736803.9
申请日：2014-07-08
发明人： VAKALOPOULOS, Alexandros , GROMOV, Alexey , FOLLMANN, Markus , BROCKSCHNIEDER, Damian , STASCH, Johannes-Peter , MARQUARDT, Tobias , TERSTEEGEN, Adrian , WUNDER, Frank , REDLICH, Gorden , LANG, Dieter , LI, Volkhart Min-Jian
IPC分类号： C07D519/04 , A61K31/53 , A61P9/10
CPC分类号： C07D519/00 , A61K31/53 , A61K45/06 , C07D519/04
摘要： The invention relates to novel benzyl-1H-pyrazolo[3,4-b]pyridines, to methods for the production thereof, to the use thereof alone or in combination for the treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
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