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公开(公告)号：EP1363912B1
公开(公告)日：2006-05-24
申请号：EP02704706.7
申请日：2002-02-11
申请人： Bayer HealthCare AG
发明人： NIEWÖHNER, Ulrich , SCHAUSS, Dagmar , KÖNIG, Gerhard , HENDRIX, Martin , BÖSS, Frank-Gerhard , VAN DER STAAY, Franz-Josef , SCHREIBER, Rudy , SCHLEMMER, Karl-Heinz , MORIWAKI, Toshiya , NIEWÖHNER, Maria Theresia
IPC分类号： C07D487/04 , A61K31/53 , A61P25/00 , C07D253/06 , C07D253/00 , C07D235/00
CPC分类号： C07D253/07 , C07D487/04
摘要： The invention relates to novel substituted imidazotriazinones, to a method for their production and to the use thereof for producing medicaments, in particular to improve perception, powers of concentration, learning capacity and/or memory retentiveness.
摘要翻译： 本发明涉及新型取代的咪唑并三嗪酮，其制备方法及其用于制备药物的用途，特别是改善知觉，注意力，学习能力和/或记忆保持力的能力。
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公开(公告)号：EP1397363A1
公开(公告)日：2004-03-17
申请号：EP02738089.8
申请日：2002-05-21
申请人： Bayer HealthCare AG
发明人： ALONSO-ALIJA, Cristina , GIELEN, Heike , HENDRIX, Martin , NIEWÖHNER, Ulrich , SCHAUSS, Dagmar , BISCHOFF, Hilmar , BURKHARDT, Nils , GEISS, Volker , SCHLEMMER, Karl-Heinz , CUTHBERT, Nigel, J. , FITZGERALD, Mary , STURTON, Richard, Graham , MICHELS, Martin
IPC分类号： C07D487/04 , A61P29/00
CPC分类号： C07D487/04 , C07D253/07
摘要： The invention relates to novel 5-Ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
摘要翻译： 本发明涉及新的5-乙基 - 咪唑并三嗪酮类，其制备方法及其在药物中的用途， 用于治疗和/或预防炎症过程和/或免疫疾病。
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公开(公告)号：EP1404677A1
公开(公告)日：2004-04-07
申请号：EP02747362.8
申请日：2002-06-10
申请人： Bayer HealthCare AG
发明人： ERGÜDEN, Jens-Kerim , BAUSER, Marcus , BURKHARDT, Nils , FLUBACHER, Dietmar , FRIEDL, Arno , GERLACH, Irene , HINZ, Volker , JORK, Reinhard , NAAB, Paul , NIEWÖHNER, Maria Theresia , REPP, Thorsten, Oliver , SCHLEMMER, Karl-Heinz , STOLTEFUSS, Jürgen , BRÜCKNER, David , HENDRIX, Martin , SCHAUSS, Dagmar , TERSTEEGEN, Adrian
IPC分类号： C07D487/04 , A61K31/415 , A61K31/53 , A61P25/28
CPC分类号： C07D487/04
摘要： The invention relates to the novel imidazotriazines of general formula (I), to methods for their production, and to the use thereof for producing drugs for the treatment and/or the prophylaxis of neurodegenerative diseases, especially Parkinson's disease.
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4.发明公开IMIDAZOTRIAZINONES DERIVATIVES AND THEIR USE AGAINST INFLAMMATORY PROCESSES AND/OR IMMUNE DISEASES 审中-公开IMIDAZOTRIAZINONDERIVATE及其用来对付炎症过程和/或免疫系统疾病
公开(公告)号：EP1399447A1
公开(公告)日：2004-03-24
申请号：EP02743040.4
申请日：2002-05-17
申请人： Bayer HealthCare AG
发明人： ALONSO-ALIJA, Cristina , GIELEN, Heike , HENDRIX, Martin , NIEWÖHNER, Ulrich , SCHAUSS, Dagmar , BISCHOFF, Hilmar , BURKHARDT, Nils , GEISS, Volker , SCHLEMMER, Karl-Heinz , CUTHBERT, Nigel, J. , FITZGERALD, Mary , STURTON, Graham
IPC分类号： C07D487/04 , A61K31/53
CPC分类号： C07D253/07 , C07D487/04
摘要： The invention relates to 7-(4-tert butyl-cyclohexyl)-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
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5.发明授权2-HETEROARYL-IMIDAZOTRIAZINONES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY OR IMMUNE DISEASES 有权2 - 杂芳基 - imidazotriazinones及其用途疾病中炎性或免疫的治疗
公开(公告)号：EP1399439B1
公开(公告)日：2006-06-14
申请号：EP02730265.2
申请日：2002-05-21
申请人： Bayer HealthCare AG
发明人： ALONSO-ALIJA, Cristina , GIELEN, Heike , HENDRIX, Martin , NIEWÖHNER, Ulrich , SCHAUSS, Dagmar , BISCHOFF, Hilmar , BURKHARDT, Nils , GEISS, Volker , SCHLEMMER, Karl-Heinz , CUTHBERT,Nigel , Cuthbert, Nigel , Fitzgerald, Mary.F. , Sturton, Graham. , NIEWÖHNER, Maria, Theresia
IPC分类号： C07D409/04 , C07D417/04 , C07D401/04 , C07D407/04 , C07D403/04 , C07D487/04 , A61K31/53 , A61P37/00 , A61P29/00 , A61P11/00 , A61P11/06
CPC分类号： C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D417/04 , C07D487/04
摘要： The invention relates to 2-Heteroaryl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases. The present invention relates to compounds of the general formula (I) in which R1 denotes 5- to 10- membered heteroaryl, which is optionally substituted by identical or different residues selected from the group consisting of halogen, (C¿1?-C4)-alkyl, trifluoromthyl, cyano, nitro und trifluoromethoxy, denotes 3-to 10-membered carbocyclyl or carbon-bonded, 4- to 10-membered heterocyclyl, whereby carbocyclyl and heterocyclyl are optionally substituted by identical or different residues selected from the group consisting of (C1-C6)-aldyl, (C1-C6)-aldoxy, hydroxy, halogen, trifluoromethyl and oxo, or denotes (C2-C10)-alkyl, which is optionally substituted by identical or different residues selected from the group the group consisting of (C1-C6)-alkoxy, hydroxy, halogen, 3-to 10-membered carbocyclyl and oxo.
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公开(公告)号：EP1521756A1
公开(公告)日：2005-04-13
申请号：EP03738083.9
申请日：2003-06-25
申请人： Bayer HealthCare AG
发明人： HENDRIX, Martin , BRÜCKNER, David , FRIEDL, Arno , GERLACH, Irene , HINZ, Volker , KELDENICH, Jörg , MAULER, Frank , SCHAUSS, Dagmar , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , YALKINOGLU, Özkan , NIEWÖHNER, Ulrich DI
IPC分类号： C07D487/04 , A61K31/53 , A61P25/16 , A61P25/18
CPC分类号： C07D487/04 , A61K31/53
摘要： The invention relates to novel hetero-cyclically substituted imidazotriazines and a method for the production and use thereof for producing drugs which are used for curing and/or preventing cancers and neurodegenerative diseases, in particular Parkinson disease and schizophrenia.
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7.发明公开2-HETEROARYL-IMIDAZOTRIAZINONES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY OR IMMUNE DISEASES 有权2 - 杂芳基 - imidazotriazinones及其用途疾病中炎性或免疫的治疗
公开(公告)号：EP1399439A1
公开(公告)日：2004-03-24
申请号：EP02730265.2
申请日：2002-05-21
申请人： Bayer HealthCare AG
发明人： ALONSO-ALIJA, Cristina , GIELEN, Heike , HENDRIX, Martin , NIEWÖHNER, Ulrich , SCHAUSS, Dagmar , BISCHOFF, Hilmar , BURKHARDT, Nils , GEISS, Volker , SCHLEMMER, Karl-Heinz , Cuthbert, Nigel , Fitzgerald, Mary.F. , Sturton, Graham. , NIEWÖHNER, Maria, Theresia
IPC分类号： C07D409/04 , C07D417/04 , C07D401/04 , C07D407/04 , C07D403/04 , C07D487/04 , A61K31/53 , A61P37/00 , A61P29/00 , A61P11/00 , A61P11/06
CPC分类号： C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D417/04 , C07D487/04
摘要： The invention relates to 2-Heteroaryl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases. The present invention relates to compounds of the general formula (I) in which R1 denotes 5- to 10- membered heteroaryl, which is optionally substituted by identical or different residues selected from the group consisting of halogen, (C¿1?-C4)-alkyl, trifluoromthyl, cyano, nitro und trifluoromethoxy, denotes 3-to 10-membered carbocyclyl or carbon-bonded, 4- to 10-membered heterocyclyl, whereby carbocyclyl and heterocyclyl are optionally substituted by identical or different residues selected from the group consisting of (C1-C6)-aldyl, (C1-C6)-aldoxy, hydroxy, halogen, trifluoromethyl and oxo, or denotes (C2-C10)-alkyl, which is optionally substituted by identical or different residues selected from the group the group consisting of (C1-C6)-alkoxy, hydroxy, halogen, 3-to 10-membered carbocyclyl and oxo.
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公开(公告)号：EP1347978B1
公开(公告)日：2005-08-31
申请号：EP01271375.6
申请日：2001-12-10
申请人： Bayer HealthCare AG
发明人： NIEWÖHNER, Ulrich , SCHAUSS, Dagmar , HENDRIX, Martin , KÖNIG, Gerhard , BÖSS, Frank-Gerhard , VAN DER STAAY, Franz-Josef , SCHREIBER, Rudy , SCHLEMMER, Karl-Heinz , GROSSER, Rolf
IPC分类号： C07D487/04 , C07D253/06 , A61K31/53 , A61P25/28
CPC分类号： C07D487/04 , A61K31/53
摘要： The invention relates to novel substituted imidazotriazinones (I), methods for the production thereof, and the use thereof for producing medicaments particularly for improving perception, concentration capacity, learning capacity and/or memory capacity.
摘要翻译： 本发明涉及新型取代的咪唑并三嗪酮（I），其制备方法及其在制备药物中的用途，特别用于改善知觉，注意力，学习能力和/或记忆能力。
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公开(公告)号：EP1397363B1
公开(公告)日：2005-05-11
申请号：EP02738089.8
申请日：2002-05-21
申请人： Bayer HealthCare AG
发明人： ALONSO-ALIJA, Cristina , GIELEN, Heike , HENDRIX, Martin , NIEWÖHNER, Ulrich , SCHAUSS, Dagmar , BISCHOFF, Hilmar , BURKHARDT, Nils , GEISS, Volker , SCHLEMMER, Karl-Heinz , CUTHBERT, Nigel, J. , FITZGERALD, Mary , STURTON, Richard, Graham , MICHELS, Martin
IPC分类号： C07D487/04 , A61P29/00
CPC分类号： C07D487/04 , C07D253/07
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10.发明授权
公开(公告)号：EP1307201B1
公开(公告)日：2004-11-24
申请号：EP01969511.3
申请日：2001-07-19
申请人： Bayer HealthCare AG
发明人： BÖSS, Frank-Gerhard , HENDRIX, Martin , KÖNIG, Gerhard , NIEWÖHNER, Ulrich , SCHLEMMER, Karl-Heinz , SCHREIBER, Rudy , VAN DER STAAY, Franz-Josef , SCHAUSS, Dagmar
IPC分类号： A61K31/505 , A61P25/28 , A61P9/10 , A61P25/24 , A61P25/16 , A61K31/52 , A61K31/519
CPC分类号： A61K31/505
摘要： The invention relates to the use of selective phosphodiesterase 2, (PDE 2), inhibitors for producing medicaments to improve cognition, powers of concentration, learning capability and/or memory retention.
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