公开(公告)号：EP1497328A2

公开(公告)日：2005-01-19

申请号：EP03746288.4

申请日：2003-04-10

申请人： Bayer HealthCare AG

发明人： SHIROO, Masahiro ,  YAMAMOTO, Noriyuki ,  HAYASHI, Fumihiko ,  FLOECKNER, Johannes ,  REINEMER, Peter ,  ENCINAS, Jeffrey ,  WATANABE, Shinichi ,  TAJIMI, Masaomi ,  KOKUBO, Toshio

IPC分类号： C07K14/70 ,  C12Q1/68 ,  G01N33/68 ,  C07K14/705

CPC分类号： G01N33/6872 ,  C07K14/705 ,  G01N2333/705 ,  G01N2500/00

摘要： Reagents which regulate human transient receptor potential channel and reagents which bind to human transient receptor potential channel gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, urinary incontinence, overactive bladder, benign prostatic hyperplasia, lower urinary tract syndromes, and CNS disorders.

公开(公告)号：EP1597262A2

公开(公告)日：2005-11-23

申请号：EP04708731.7

申请日：2004-02-06

申请人： Bayer HealthCare AG

发明人： STADLER, Marc ,  SEIP, Stephan ,  MÜLLER, Hartwig ,  MAYER-BARTSCHMID, Anke ,  BRÜNING, Michael-Alexander ,  BENET-BUCHHOLZ, Jordi ,  TOGAME, Hiroko ,  DODO, Reiko ,  REINEMER, Peter ,  BACON, Kevin ,  FUCHIKAMI, Kinji ,  MATSUKAWA, Satoko ,  URBAHNS, Klaus

IPC分类号： C07D491/04 ,  C07D207/26 ,  A61P35/00

CPC分类号： C12P17/10 ,  C07D207/277 ,  C07D491/04 ,  C12P17/188 ,  C12R1/465

摘要： The present invention relates to substituted heterocycles, processes for their preparation, and their use in medicaments, especially for the treatment of inflammatory disease, i.e. asthma, or cancer.

公开(公告)号：EP1373239A1

公开(公告)日：2004-01-02

申请号：EP02757722.0

申请日：2002-03-25

申请人： Bayer HealthCare AG

发明人： SCHMECK, Carsten ,  MÜLLER, Ulrich ,  SCHMIDT, Gunter ,  PERNERSTORFER, Josef ,  BISCHOFF, Hilmar ,  KRETSCHMER, Axel ,  VÖHRINGER, Verena ,  FAESTE, Christiane ,  HANING, Helmut ,  HAUSWALD, Markus ,  SCHMIDT, Delf ,  ZOCHE, Martin ,  APELER, Heiner ,  JONGHAUS, Willi ,  REINEMER, Peter

IPC分类号： C07D307/78 ,  C07D307/87 ,  A61K31/343 ,  A61P7/00

CPC分类号： C07D307/85 ,  C07D307/80 ,  C07D307/84

摘要： The invention relates to substituted benzofuran derivatives, a method for the production thereof and the use of the same as pharmaceuticals for treating Alzheimer's disease, cardiovascular diseases and diabetes. The effectiveness of the compounds is associated with decreasing serum cholesterol. Said derivatives correspond to formula (I) wherein Z represents O, S, SO, SO2, CH2, CHF, CF2 or NR8; R8 represents hydrogen or (C¿1?-C4) alkyl; R?5¿ and the two carbon atoms of the phenyl ring form a saturated or unsaturated furan ring which is optionally identically or differently substituted once or twice; R7 represents hydrogen or a cation or a group, preferably such as alkyl or acetyl, which can be split under physiological conditions during the formation of an OH function.

公开(公告)号：EP1828233A2

公开(公告)日：2007-09-05

申请号：EP05819949.8

申请日：2005-12-13

申请人： Bayer HealthCare AG

发明人： REINEMER, Peter ,  GIELEN-HAERTWIG, Heike ,  ROSENTRETER, Ulrich ,  LI, Volkhart ,  HARRENGA, Axel ,  SCHOMBURG, Dietmar ,  NIEFIND, Karsten ,  HANSEN, Guido, c/o Biota Structural Biology Lab.

IPC分类号： C07K14/435 ,  C07D239/22

CPC分类号： C07D239/36 ,  C07K2299/00 ,  C12N9/6448 ,  C12Y304/21037

摘要： This invention relates to crystallised human neutrophil elastase and the use of its three-dimensional structure to design modulators for human neutrophil elastase.