公开(公告)号：EP1824844B1

公开(公告)日：2008-11-05

申请号：EP05815232.3

申请日：2005-11-28

申请人： Bayer HealthCare AG

发明人： RÖHRIG, Susanne ,  JESKE, Mario ,  AKBABA, Metin ,  ROSENTRETER, Ulrich ,  BOYER, Stephen ,  FISCHER, Karin ,  POHLMANN, Jens ,  TUCH, Arounarith ,  PERZBORN, Elisabeth ,  GERDES, Christoph ,  SCHLEMMER, Karl-Heinz ,  BURKHARDT, Nils ,  ALLERHEILIGEN, Swen ,  NELL, Peter ,  ARNDT, Sabine ,  LOBELL, Mario

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14 ,  A61K31/5377 ,  A61P7/02

CPC分类号： C07D491/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14

摘要： The invention relates to novel pyrazine dicarboxamides, methods for the use thereof, their use for treating and/or preventing diseases as well as to their use for producing medicaments for treating and/or preventing diseases, particularly thromboembolic disorders.

公开(公告)号：EP1537081B1

公开(公告)日：2008-10-15

申请号：EP03790905.8

申请日：2003-08-18

申请人： Bayer HealthCare AG

发明人： GIELEN-HAERTWIG, Heike ,  MIN-JIAN LI, Volkhart ,  ROSENTRETER, Ulrich ,  SCHLEMMER, Karl-Heinz ,  ALLERHEILIGEN, Swen ,  TELAN, Leila ,  BÄRFACKER, Lars ,  KELDENICH, Jörg ,  FITZGERALD, Mary, F. ,  NASH, Kevin ,  ALBRECHT, Barbara ,  MEURER, Dirk

IPC分类号： C07D211/90 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  A61K31/4422 ,  A61P9/00

CPC分类号： C07D401/04 ,  C07D211/90 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04

摘要： The invention relates to novel dihydropyridine derivatives, of Formula (I) processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.

公开(公告)号：EP1802594A1

公开(公告)日：2007-07-04

申请号：EP05786857.2

申请日：2005-09-27

申请人： Bayer HealthCare AG

发明人： DITTRICH-WENGENROTH, Elke ,  BÄRFACKER, Lars ,  KRETSCHMER, Axel ,  HIRTH-DIETRICH, Claudia ,  ELLINGHAUS, Peter ,  RAABE, Martin ,  BISCHOFF, Hilmar ,  PILGER, Christian ,  ROSENTRETER, Ulrich ,  BARTEL, Stephan ,  LUSTIG, Klemens ,  KERN, Armin ,  LANG, Dieter

IPC分类号： C07D273/04 ,  A61K31/5395 ,  C07D413/12

CPC分类号： C07D273/04 ,  C07D413/12

摘要： The invention relates to novel 1,3,4-oxadiazine-5-on derivatives of general formula (I), methods for the production thereof, the use thereof for treating and/or preventing diseases, and the use thereof for producing medicaments used for the treatment and/or prevention of diseases, preferably cardiovascular diseases, especially dyslipidemia and arteriosclerosis.

公开(公告)号：EP1732901A1

公开(公告)日：2006-12-20

申请号：EP05715944.4

申请日：2005-03-11

申请人： Bayer HealthCare AG

发明人： ZIMMERMANN, Holger ,  BRÜCKNER, David ,  HEIMBACH, Dirk ,  HENDRIX, Martin ,  HENNINGER, Kerstin ,  HEWLETT, Guy ,  ROSENTRETER, Ulrich ,  KELDENICH, Jörg ,  LANG, Dieter ,  RADTKE, Martin

IPC分类号： C07D233/90 ,  C07D401/12 ,  C07D403/12 ,  A61K31/4164 ,  A61P31/12

CPC分类号： C07D233/90 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.

公开(公告)号：EP1537081A1

公开(公告)日：2005-06-08

申请号：EP03790905.8

申请日：2003-08-18

申请人： Bayer HealthCare AG

发明人： GIELEN-HAERTWIG, Heike ,  MIN-JIAN LI, Volkhart ,  ROSENTRETER, Ulrich ,  SCHLEMMER, Karl-Heinz ,  ALLERHEILIGEN, Swen ,  TELAN, Leila ,  BÄRFACKER, Lars ,  KELDENICH, Jörg ,  FITZGERALD, Mary, F. ,  NASH, Kevin ,  ALBRECHT, Barbara ,  MEURER, Dirk

IPC分类号： C07D211/90 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  A61K31/4422 ,  A61P9/00

CPC分类号： C07D401/04 ,  C07D211/90 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04

摘要： The invention relates to novel dihydropyridine derivatives, of Formula (I) processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.

公开(公告)号：EP1377569A1

公开(公告)日：2004-01-07

申请号：EP02732498.7

申请日：2002-03-19

申请人： Bayer HealthCare AG

发明人： ROSENTRETER, Ulrich ,  KRÄMER, Thomas ,  VAUPEL, Andrea ,  HÜBSCH, Walter ,  DIEDRICHS, Nicole ,  KRAHN, Thomas ,  DEMBOWSKY, Klaus ,  STASCH, Johannes-Peter ,  SHIMADA, Mitsuyuki

IPC分类号： C07D405/04 ,  C07D405/14 ,  C07D213/85 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/4418 ,  C07D417/14

CPC分类号： C07D405/04 ,  C07D213/84 ,  C07D213/85 ,  C07D405/14 ,  C07D417/14

摘要： The invention relates to the compounds of formula (I), to a method for producing them and to their use as medicaments.

公开(公告)号：EP1828233A2

公开(公告)日：2007-09-05

申请号：EP05819949.8

申请日：2005-12-13

申请人： Bayer HealthCare AG

发明人： REINEMER, Peter ,  GIELEN-HAERTWIG, Heike ,  ROSENTRETER, Ulrich ,  LI, Volkhart ,  HARRENGA, Axel ,  SCHOMBURG, Dietmar ,  NIEFIND, Karsten ,  HANSEN, Guido, c/o Biota Structural Biology Lab.

IPC分类号： C07K14/435 ,  C07D239/22

CPC分类号： C07D239/36 ,  C07K2299/00 ,  C12N9/6448 ,  C12Y304/21037

摘要： This invention relates to crystallised human neutrophil elastase and the use of its three-dimensional structure to design modulators for human neutrophil elastase.

公开(公告)号：EP1824844A1

公开(公告)日：2007-08-29

申请号：EP05815232.3

申请日：2005-11-28

申请人： Bayer HealthCare AG

发明人： RÖHRIG, Susanne ,  JESKE, Mario ,  AKBABA, Metin ,  ROSENTRETER, Ulrich ,  BOYER, Stephen ,  FISCHER, Karin ,  POHLMANN, Jens ,  TUCH, Arounarith ,  PERZBORN, Elisabeth ,  GERDES, Christoph ,  SCHLEMMER, Karl-Heinz ,  BURKHARDT, Nils ,  ALLERHEILIGEN, Swen ,  NELL, Peter ,  ARNDT, Sabine ,  LOBELL, Mario

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14 ,  A61K31/5377 ,  A61P7/02

CPC分类号： C07D491/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14

摘要： The invention relates to novel pyrazine dicarboxamides, methods for the use thereof, their use for treating and/or preventing diseases as well as to their use for producing medicaments for treating and/or preventing diseases, particularly thromboembolic disorders.

摘要翻译： 本发明涉及新的吡嗪二甲酰胺，其用途的方法，它们用于治疗和/或预防疾病的用途，以及它们用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

公开(公告)号：EP1368320B1

公开(公告)日：2006-08-16

申请号：EP02722101.9

申请日：2002-02-20

申请人： Bayer HealthCare AG

发明人： ROSENTRETER, Ulrich ,  KRÄMER, Thomas ,  VAUPEL, Andrea ,  HÜBSCH, Walter ,  DIEDRICHS, Nicole ,  KRAHN, Thomas ,  DEMBOWSKY, Klaus ,  STASCH, Johannes-Peter

IPC分类号： C07D213/85 ,  A61K31/4418 ,  C07D405/04 ,  C07D417/12 ,  C07D409/12 ,  A61K31/443 ,  A61K31/4436 ,  A61P9/00

CPC分类号： C07D405/04 ,  C07D213/85 ,  C07D409/14 ,  C07D417/14

摘要： The use of compounds of formula (I) as medicaments, novel compounds of formula (I) and a method for production thereof are disclosed. Compounds of formula (I) are effective as adenosine receptor ligands.

公开(公告)号：EP1539710A1

公开(公告)日：2005-06-15

申请号：EP03794956.7

申请日：2003-08-28

申请人： Bayer HealthCare AG

发明人： GIELEN-HAERTWIG, Heike ,  MIN-JIAN LI ,Volkhart ,  ROSENTRETER, Ulrich ,  SCHLEMMER, Karl-Heinz ,  ALLERHEILIGEN, Swen ,  TELAN, Leila ,  BÄRFACKER, Lars ,  KELDENICH, Jörg ,  FITZGERALD, Mary F. ,  NASH, Kevin ,  ALBRECHT, Barbara ,  MEURER, Dirk

IPC分类号： C07D239/40 ,  C07D239/38 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/505 ,  A61K31/506 ,  A61P9/00 ,  A61P29/00

CPC分类号： C07D239/22 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

摘要： The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.