公开(公告)号：EP1802594A1

公开(公告)日：2007-07-04

申请号：EP05786857.2

申请日：2005-09-27

申请人： Bayer HealthCare AG

发明人： DITTRICH-WENGENROTH, Elke ,  BÄRFACKER, Lars ,  KRETSCHMER, Axel ,  HIRTH-DIETRICH, Claudia ,  ELLINGHAUS, Peter ,  RAABE, Martin ,  BISCHOFF, Hilmar ,  PILGER, Christian ,  ROSENTRETER, Ulrich ,  BARTEL, Stephan ,  LUSTIG, Klemens ,  KERN, Armin ,  LANG, Dieter

IPC分类号： C07D273/04 ,  A61K31/5395 ,  C07D413/12

CPC分类号： C07D273/04 ,  C07D413/12

摘要： The invention relates to novel 1,3,4-oxadiazine-5-on derivatives of general formula (I), methods for the production thereof, the use thereof for treating and/or preventing diseases, and the use thereof for producing medicaments used for the treatment and/or prevention of diseases, preferably cardiovascular diseases, especially dyslipidemia and arteriosclerosis.

公开(公告)号：EP1685112A2

公开(公告)日：2006-08-02

申请号：EP04790836.3

申请日：2004-10-26

申请人： Bayer HealthCare AG

发明人： BOUCHON, Axel ,  DIEDRICHS, Nicole ,  HERMANN, Achim ,  LUSTIG, Klemens ,  MEIER, Heinrich ,  PERNERSTORFER, Josef ,  REISSMÜLLER, Elke ,  MOGI, Muneto ,  FUJISHIMA, Hiroshi ,  TAJIMI, Masaomi, 1-8-17, Sakuragaoka, Seika-cho ,  YAMAMOTO, Noriyuki

IPC分类号： C07D215/00

CPC分类号： C07D215/38

摘要： This invention relates to tetrahydro quinolinylurea derivatives (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-quinolinylurea ueri votive (J.) of the present invention has vanilloid receptor (VRl) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VRl activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), beniyn proscatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).

摘要翻译： 本发明涉及可用作药物制剂活性成分的四氢喹啉基脲衍生物（Ⅰ）及其盐。 本发明的四氢喹啉基尿酸还原剂（J.）具有类香草素受体（VR1）拮抗活性，并且可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗泌尿科疾病或病症， 如逼尿肌过度活动（膀胱活动过度），尿失禁，神经原性逼尿肌过度活动（逼尿肌反射过度），特发性逼尿肌过度活动（逼尿肌不稳定），beniyn前列腺增生和下尿路症状; 慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风和炎症如哮喘和慢性阻塞性肺（气道）疾病（COPD）。

公开(公告)号：EP2037930A1

公开(公告)日：2009-03-25

申请号：EP07764815.2

申请日：2007-06-25

申请人： Bayer HealthCare AG

发明人： VON NUSSBAUM, Franz ,  GIELEN-HAERTWIG, Heike ,  KLEIN, Martina ,  LI, Volkhart, Min-Jian ,  MEIBOM, Daniel ,  SANDNER, Peter ,  LUSTIG, Klemens ,  SCHÄFER, Stefan

IPC分类号： A61K31/513 ,  C07D239/22 ,  C07D401/02

CPC分类号： C07D239/22

摘要： The invention relates to the use of 1,4-diaryl-dihydropyrimidine-2-on derivatives of formula (I) to treat and/or prevent pulmonary arterial hypertension and other forms of pulmonary hypertension, as well as the use thereof for the production of drugs to treat and/or prevent pulmonary arterial hypertension and other forms of pulmonary hypertension.

公开(公告)号：EP1866289A1

公开(公告)日：2007-12-19

申请号：EP06707442.7

申请日：2006-03-07

申请人： Bayer HealthCare AG

发明人： WOLTERING, Elisabeth ,  TUCH, Arounarith ,  DITTRICH-WENGENROTH, Elke ,  KRETSCHMER, Axel ,  BÄRFACKER, Lars ,  BAUSER, Marcus ,  ELLINGHAUS, Peter ,  LUSTIG, Klemens ,  POOK, Elisabeth ,  WEBER, Olaf

IPC分类号： C07D239/34 ,  C07D239/28 ,  A61K31/515 ,  A61P3/06

CPC分类号： C07D239/28 ,  C07D239/34

摘要： The invention relates to pyrimidine carboxylic acid derivatives of formula (I), to methods for the production thereof, to their use for treating and/or preventing diseases, and their use for producing medicaments for treating and/or preventing diseases, preferably for treating and/or preventing cardiovascular diseases, in particular, dyslipidemias and arteriosclerosis.

公开(公告)号：EP1476164B1

公开(公告)日：2005-11-02

申请号：EP03737277.8

申请日：2003-01-27

申请人： Bayer HealthCare AG

发明人： ERGÜDEN, Jens-Kerim ,  KOLKHOF, Peter ,  CASTRO-PALOMINO, Julio ,  KUHL, Alexander ,  KAST, Raimund ,  STASCH, Johannes-Peter ,  TINEL, Hanna ,  MÜNTER, Klaus ,  LUSTIG, Klemens ,  PERNERSTORFER, Josef ,  BECHEM, Martin ,  HÜSER, Jörg

IPC分类号： A61K31/498 ,  C07D405/12 ,  C07D401/12 ,  C07D409/12 ,  C07D403/12 ,  A61P9/00

CPC分类号： C07D401/12 ,  C07D405/12 ,  C07D409/12

公开(公告)号：EP1797045A1

公开(公告)日：2007-06-20

申请号：EP05782757.8

申请日：2005-09-10

申请人： Bayer HealthCare AG

发明人： DITTRICH-WENGENROTH, Elke ,  BÄRFACKER, Lars ,  KRETSCHMER, Axel ,  HIRTH-DIETRICH, Claudia ,  ELLINGHAUS, Peter ,  RAABE, Martin ,  BISCHOFF, Hilmar ,  PILGER, Christian ,  ROSENTRETER, Ulrich ,  BARTEL, Stephan ,  LUSTIG, Klemens ,  KERN, Armin ,  LANG, Dieter ,  BAUSER, Marcus

IPC分类号： C07D239/42 ,  A61K31/505 ,  A61K31/506 ,  C07D239/46 ,  C07D239/48 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D239/42 ,  C07D405/12

摘要： The invention relates to novel pyrimidine derivatives of general formula (I), methods for the production thereof, their use for treating and/or preventing diseases, and to their use for producing medicaments for treating and/or preventing diseases, preferably for treating and/or preventing cardiovascular diseases, particularly dyslipidemia, arteriosclerosis, insufficiency of the heart, thrombosis and metabolic syndrome.

公开(公告)号：EP1999123A1

公开(公告)日：2008-12-10

申请号：EP07711808.1

申请日：2007-03-07

申请人： Bayer HealthCare AG

发明人： SCHMECK, Carsten ,  BISCHOFF, Hilmar ,  LI, Volkhart ,  LUSTIG, Klemens ,  THUTEWOHL, Michael ,  VAKALOPOULOS, Alexandros ,  WEBER, Olaf

IPC分类号： C07D311/22 ,  C07D311/96 ,  A61K31/353 ,  A61P9/00

CPC分类号： C07D311/22 ,  C07D311/96

摘要： The present application relates to substituted chromanol derivatives, to processes for their preparation, to their use alone or in combinations for treatment and/or prevention of diseases and to their use for producing medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular disorders.

公开(公告)号：EP1802600A1

公开(公告)日：2007-07-04

申请号：EP05794912.5

申请日：2005-10-12

申请人： Bayer HealthCare AG

发明人： LAMPE, Thomas ,  ALONSO-ALIJA, Cristina ,  STELTE-LUDWIG, Beatrix ,  SANDNER, Peter ,  BAUSER, Marcus ,  BECK, Hartmut ,  LUSTIG, Klemens ,  ROSENTRETER, Ulrich ,  STAHL, Elke ,  TAKAGI, Hiroko

IPC分类号： C07D333/38 ,  C07D231/14 ,  C07C235/00 ,  A61P13/00

CPC分类号： C07C233/40 ,  C07C233/36 ,  C07C233/37 ,  C07C233/38 ,  C07C233/62 ,  C07C233/73 ,  C07C233/78 ,  C07C271/20 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07D231/14 ,  C07D333/38

摘要： The present invention relates to novel substituted benzyloxy-phenylmethylamide derivatives of formula (I), processes for their preparation, and their use in medicaments, especially for the prophylaxis and treatment of diseases associated with Cold Menthol Receptor 1 (CMR-1) activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).

摘要翻译： 本发明涉及新的substituiertem苄氧基苯基甲基衍生物，其制备方法，及其在药物中使用，爱尤其用于治疗与冷薄荷醇受体1（CMR-1）的活性，特别是用于治疗相关的疾病的预防和治疗 泌尿科疾病或病症，：如逼尿肌过度活动（膀胱过度活动症），尿失禁，神经原性逼尿肌oeractivity（逼尿肌亢进），特发性逼肌活动过度（逼尿肌不稳定），良性前列腺增生，和下尿路症状; 慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风，和炎性病症：诸如哮喘和慢性阻塞性肺（或气道）疾病（COPD）。

公开(公告)号：EP1140809B1

公开(公告)日：2005-08-31

申请号：EP99967934.3

申请日：1999-12-13

申请人： Bayer HealthCare AG

发明人： ALBERS, Markus ,  URBAHNS, Klaus ,  VAUPEL, Andrea ,  HÄRTER, Michael ,  SCHMIDT, Delf ,  STELTE-LUDWIG, Beatrix ,  GERDES, Christoph ,  STAHL, Elke ,  KELDENICH, Jörg ,  BRÜGGEMEIER, Ulf ,  LUSTIG, Klemens

IPC分类号： C07C311/19 ,  C07C275/42 ,  C07C311/10 ,  C07C311/47 ,  C07D213/40 ,  C07D213/75 ,  C07D235/30 ,  A61K31/18 ,  A61K31/44 ,  A61K31/4184 ,  A61P35/00 ,  A61P19/10 ,  A61P27/02

CPC分类号： C07D213/40 ,  C07C271/22 ,  C07C275/42 ,  C07C311/06 ,  C07C311/10 ,  C07C311/14 ,  C07C311/19 ,  C07C311/37 ,  C07C311/46 ,  C07C311/47 ,  C07C335/20 ,  C07C2601/02 ,  C07D207/22 ,  C07D213/55 ,  C07D213/74 ,  C07D213/75 ,  C07D213/82 ,  C07D231/12 ,  C07D231/18 ,  C07D233/50 ,  C07D233/56 ,  C07D233/64 ,  C07D233/84 ,  C07D233/88 ,  C07D233/90 ,  C07D235/14 ,  C07D235/30 ,  C07D249/08 ,  C07D261/10 ,  C07D261/14 ,  C07D263/58 ,  C07D277/42 ,  C07D277/48 ,  C07D277/54 ,  C07D277/82 ,  C07D285/10 ,  C07D285/135 ,  C07D285/14 ,  C07D295/13 ,  C07D295/15 ,  C07D307/14 ,  C07D307/52 ,  C07D307/68 ,  C07D333/34 ,  C07D333/36 ,  C07D401/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

公开(公告)号：EP1334086B1

公开(公告)日：2005-04-06

申请号：EP01985700.2

申请日：2001-09-13

申请人： Bayer HealthCare AG

发明人： HEIL, Markus ,  MEIER, Heinrich ,  NAAB, Paul ,  VOERSTE, Arnd ,  DE VRY, Jean-Marie-Viktor ,  DENZER, Dirk ,  MAULER, Frank ,  LUSTIG, Klemens ,  LENFERS, Jan-Bernd

IPC分类号： C07C309/65 ,  C07C311/08 ,  C07C311/09 ,  A61K31/18 ,  A61K31/255 ,  A61P25/28

CPC分类号： C07C309/65 ,  C07C311/08 ,  C07C311/09