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公开(公告)号：EP2817311B1
公开(公告)日：2016-04-06
申请号：EP13705982.0
申请日：2013-02-20
发明人： LOBELL, Mario , HÜBSCH, Walter , SCHIROK, Hartmut , HÉROULT, Mélanie , BROHM, Dirk , COLLIN, Marie-Pierre , GRÜNEWALD, Sylvia , LUSTIG, Klemens , BÖMER, Ulf , VOEHRINGER, Verena , LINDNER, Niels
IPC分类号： A61K31/53 , A61K31/5377 , A61K31/5513 , C07D519/00 , C07D487/04
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5513 , C07D409/04 , C07D409/14 , C07D519/00
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2.发明授权SUBSTITUIERTE ARYLIMIDAZ0L0NE UND -TRIAZ0L0NE ALS INHIBITOREN DER VASOPRESSIN-REZEPTOREN 有权取代ARYLIMIDAZ0L0NE和-TRIAZ0L0NE加压素受体的抑制剂
公开(公告)号：EP2027096B8
公开(公告)日：2012-09-26
申请号：EP07725514.9
申请日：2007-05-21
发明人： MEIER, Heinrich , BENDER, Eckhard , BRÜGGEMEIER, Ulf , FLAMME, Ingo , KARTHAUS, Dagmar , KOLKHOF, Peter , MEIBOM, Daniel , SCHNEIDER, Dirk , VOEHRINGER, Verena , FÜRSTNER, Chantal , KELDENICH, Jörg , LANG, Dieter , POOK, Elisabeth , SCHMECK, Carsten
IPC分类号： C07D233/70 , C07D249/12 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/14 , A61K31/4166 , A61K31/4178 , A61K31/4196 , A61P9/00
CPC分类号： C07D249/12 , C07D233/70 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/14
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公开(公告)号：EP2817311A1
公开(公告)日：2014-12-31
申请号：EP13705982.0
申请日：2013-02-20
发明人： LOBELL, Mario , HÜBSCH, Walter , SCHIROK, Hartmut , HÉROULT, Mélanie , BROHM, Dirk , COLLIN, Marie-Pierre , GRÜNEWALD, Sylvia , LUSTIG, Klemens , BÖMER, Ulf , VOEHRINGER, Verena , LINDNER, Niels
IPC分类号： C07D487/04 , A61P35/00 , A61K31/4985
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5513 , C07D409/04 , C07D409/14 , C07D519/00
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
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4.发明公开HYDROXYMETHYLARYL-SUBSTITUTED PYRROLOTRIAZINES AS ALK1 INHIBITORS 有权HYDROXYMETHYLARYL-取代的吡咯并三ALK1抑制剂
公开(公告)号：EP2726482A1
公开(公告)日：2014-05-07
申请号：EP12730515.9
申请日：2012-06-26
发明人： KLAR, Jürgen , VOEHRINGER, Verena , TELSER, Joachim , LOBELL, Mario , SÜßMEIER, Frank , LI, Volkhart Min-Jian , BÖTTGER, Michael , GOLZ, Stefan , LANG, Dieter , SCHLEMMER, Karl-Heinz , SCHLANGE, Thomas , SCHALL, Andreas , FU, Wenlang
IPC分类号： C07D487/04 , A61K31/53 , A61P27/00
CPC分类号： A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
摘要： This invention relates to novel 5-[(hydroxymethyl)aryl] -substituted pyrrolo[2, 1-f][1, 2, 4] triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.
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5.发明授权HYDROXYMETHYLARYL-SUBSTITUTED PYRROLOTRIAZINES AS ALK1 INHIBITORS 有权HYDROXYMETHYLARYL-取代的吡咯并三ALK1抑制剂
公开(公告)号：EP2726482B1
公开(公告)日：2016-07-20
申请号：EP12730515.9
申请日：2012-06-26
发明人： KLAR, Jürgen , VOEHRINGER, Verena , TELSER, Joachim , LOBELL, Mario , SÜßMEIER, Frank , LI, Volkhart Min-Jian , BÖTTGER, Michael , GOLZ, Stefan , LANG, Dieter , SCHLEMMER, Karl-Heinz , SCHLANGE, Thomas , SCHALL, Andreas , FU, Wenlang
IPC分类号： C07D487/04 , A61K31/53 , A61P27/00
CPC分类号： A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
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