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公开(公告)号：EP2751106B1
公开(公告)日：2017-10-18
申请号：EP12766292.2
申请日：2012-08-30
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , GRIEBENOW, Nils , LANG, Dieter , WUNDER, Frank , HÜBSCH, Walter , LINDNER, Niels , VAKALOPOULOS, Alexandros , TERSTEEGEN, Adrian
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61K31/519 , A61P9/00
CPC分类号： A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/5383 , A61K31/5386 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/20 , C07D498/08 , C07D519/00
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2.发明公开SUBSTITUIERTE 8-ALKOXY-2-AMINOTETRALIN-DERIVATE UND IHRE VERWENDUNG 有权替代品8-ALKOXY-2-AMINOTETRALIN-DERIVATE UND IHRE VERWENDUNG
公开(公告)号：EP2569277A1
公开(公告)日：2013-03-20
申请号：EP11720740.7
申请日：2011-05-09
发明人： HÜBSCH, Walter , HAHN, Michael , VAKALOPOULOS, Alexandros , LI, Volkhart, Min-Jian , WUNDER, Frank , STASCH, Johannes-Peter , SCHLEMMER, Karl-Heinz , STOLL, Friederike , LINDNER, Niels
IPC分类号： C07C229/38 , A61K31/195
CPC分类号： C07C229/38 , A61K31/197 , A61K31/4015 , A61K31/421 , A61K31/4245 , A61K31/4402 , A61K31/5375 , A61K45/06 , C07C2602/10 , C07D207/27 , C07D213/30 , C07D263/22 , C07D265/32 , C07D271/06
摘要： The application relates to novel substituted 8-alkoxy-2-aminotetralin derivatives, methods for the production thereof, the use thereof for the treatment and/or prevention of diseases, and the use thereof for producing medicaments used for the treatment and/or prevention of diseases, in particular cardiovascular diseases.
摘要翻译： 本申请涉及新的取代的8-烷氧基-2-氨基四氢萘衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：EP2817311B1
公开(公告)日：2016-04-06
申请号：EP13705982.0
申请日：2013-02-20
发明人： LOBELL, Mario , HÜBSCH, Walter , SCHIROK, Hartmut , HÉROULT, Mélanie , BROHM, Dirk , COLLIN, Marie-Pierre , GRÜNEWALD, Sylvia , LUSTIG, Klemens , BÖMER, Ulf , VOEHRINGER, Verena , LINDNER, Niels
IPC分类号： A61K31/53 , A61K31/5377 , A61K31/5513 , C07D519/00 , C07D487/04
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5513 , C07D409/04 , C07D409/14 , C07D519/00
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4.发明授权
公开(公告)号：EP2569277B1
公开(公告)日：2015-07-22
申请号：EP11720740.7
申请日：2011-05-09
发明人： HÜBSCH, Walter , HAHN, Michael , VAKALOPOULOS, Alexandros , LI, Volkhart, Min-Jian , WUNDER, Frank , STASCH, Johannes-Peter , SCHLEMMER, Karl-Heinz , STOLL, Friederike , LINDNER, Niels
IPC分类号： C07C229/38 , A61K31/197 , C07D263/22 , C07D265/32 , C07D213/30 , A61K31/4015 , A61K31/4245
CPC分类号： C07C229/38 , A61K31/197 , A61K31/4015 , A61K31/421 , A61K31/4245 , A61K31/4402 , A61K31/5375 , A61K45/06 , C07C2602/10 , C07D207/27 , C07D213/30 , C07D263/22 , C07D265/32 , C07D271/06
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公开(公告)号：EP2635576B1
公开(公告)日：2015-02-25
申请号：EP11782103.3
申请日：2011-11-03
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , ACKERSTAFF, Jens , GRIEBENOW, Nils , LINDNER, Niels , WUNDER, Frank , LI, Volkhart, Min-Jian
IPC分类号： C07D471/04 , A61K31/416 , A61P9/00
CPC分类号： C07D471/04 , A61K31/506 , A61K45/06
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公开(公告)号：EP2635576A1
公开(公告)日：2013-09-11
申请号：EP11782103.3
申请日：2011-11-03
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , ACKERSTAFF, Jens , GRIEBENOW, Nils , LINDNER, Niels , WUNDER, Frank , LI, Volkhart, Min-Jian
IPC分类号： C07D471/04 , A61K31/416 , A61P9/00
CPC分类号： C07D471/04 , A61K31/506 , A61K45/06
摘要： The invention relates to novel benzyl-substituted carbamates, to methods for producing same, to the use thereof alone or in combination for treating and/or preventing illnesses, and to the use thereof to produce drugs for treating and/or preventing illnesses, in particular for treating and/or preventing cardiovascular diseases.
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公开(公告)号：EP2807162B1
公开(公告)日：2017-06-07
申请号：EP13700765.4
申请日：2013-01-22
发明人： SÜßMEIER, Frank , LOBELL, Mario , GRÜNEWALD, Sylvia , HÄRTER, Michael , BUCHMANN, Bernd , TELSER, Joachim , JÖRIßEN, Hannah , HÉROULT, Mélanie , KAHNERT, Antje , LUSTIG, Klemens , LINDNER, Niels
IPC分类号： C07D487/04 , A61K31/4188 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4188 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K45/06
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8.发明授权
公开(公告)号：EP2791143B1
公开(公告)日：2016-02-24
申请号：EP12809680.7
申请日：2012-12-11
发明人： COLLIN, Marie-Pierre , BROHM, Dirk , HÉROULT, Mélanie , LOBELL, Mario , HÜBSCH, Walter , LUSTIG, Klemens , GRÜNEWALD, Sylvia , BÖMER, Ulf , VÖHRINGER, Verena , LINDNER, Niels
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/553 , C07D409/04 , C07D409/14
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公开(公告)号：EP2817311A1
公开(公告)日：2014-12-31
申请号：EP13705982.0
申请日：2013-02-20
发明人： LOBELL, Mario , HÜBSCH, Walter , SCHIROK, Hartmut , HÉROULT, Mélanie , BROHM, Dirk , COLLIN, Marie-Pierre , GRÜNEWALD, Sylvia , LUSTIG, Klemens , BÖMER, Ulf , VOEHRINGER, Verena , LINDNER, Niels
IPC分类号： C07D487/04 , A61P35/00 , A61K31/4985
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5513 , C07D409/04 , C07D409/14 , C07D519/00
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
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公开(公告)号：EP2807162A1
公开(公告)日：2014-12-03
申请号：EP13700765.4
申请日：2013-01-22
发明人： SÜßMEIER, Frank , LOBELL, Mario , GRÜNEWALD, Sylvia , HÄRTER, Michael , BUCHMANN, Bernd , TELSER, Joachim , JÖRIßEN, Hannah , HEROULT, Melanie , KAHNERT, Antje , LUSTIG, Klemens , LINDNER, Niels
IPC分类号： C07D487/04 , A61K31/4188 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4188 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K45/06
摘要： The present application relates to novel 1-phenyl-1
H -imidazo[1,2-b]pyrazole derivatives of the fomula (I), to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders where neovascularization is involved, for example cancers and tumors. Such treatments can be effected as a monotherapy or else in combination with other medicaments or further therapeutic measures.
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