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公开(公告)号：EP2794596B1
公开(公告)日：2017-05-31
申请号：EP12808361.5
申请日：2012-12-17
发明人： HITCHCOCK, Marion , MENGEL, Anne , RICHTER, Anja , BRIEM, Hans , EIS, Knut , PÜTTER, Vera , SIEMEISTER, Gerhard , PRECHTL, Stefan , FERNÁNDEZ-MONTALVÁN, Amaury Ernesto , STEGMANN, Christian , HOLTON, Simon , GNOTH, Mark Jean , PREUSSE, Cornelia
IPC分类号： C07D401/14 , A61K31/4155 , A61P35/00
CPC分类号： C07D401/14 , A61K31/506 , C07D405/14
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2.发明授权SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. 有权用作BUB1激酶抑制剂用于治疗过度增殖性疾病的取代苯并噻唑类化合物。
公开(公告)号：EP2763982B1
公开(公告)日：2018-01-10
申请号：EP12766997.6
申请日：2012-10-04
发明人： HITCHCOCK, Marion , MENGEL, Anne , PÜTTER, Vera , SIEMEISTER, Gerhard , WENGNER, Antje Margret , BRIEM, Hans , EIS, Knut , SCHULZE, Volker , FERNANDEZ-MONTALVAN, Amaury Ernesto , PRECHTL, Stefan , HOLTON, Simon , FANGHÄNEL, Jörg , LIENAU, Philip , PREUSSE, Cornelia , GNOTH, Mark Jean
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D498/04 , A61K31/506 , A61P35/00
CPC分类号： C07D498/04 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14
摘要： Compounds of formula (1) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
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3.发明公开SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. 有权SUBSTITUIERTE BENZYLINDAZOLE ZUR VERWENDUNG ALS BUB1-KINASEHEMMER BEI DER BEHANDLUNG HYPERPROLIFERATIVER ERKRANKUNGEN
公开(公告)号：EP2763982A1
公开(公告)日：2014-08-13
申请号：EP12766997.6
申请日：2012-10-04
发明人： HITCHCOCK, Marion , MENGEL, Anne , PÜTTER, Vera , SIEMEISTER, Gerhard , WENGNER, Antje Margret , BRIEM, Hans , EIS, Knut , SCHULZE, Volker , FERNANDEZ-MONTALVAN, Amaury Ernesto , PRECHTL, Stefan , HOLTON, Simon , FANGHÄNEL, Jörg , LIENAU, Philip , PREUSSE, Cornelia , GNOTH, Mark Jean
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D498/04 , A61K31/506 , A61P35/00
CPC分类号： C07D498/04 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14
摘要： Compounds of formula (1) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物，其制备方法及其作为药物的用途。
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公开(公告)号：EP2794596A1
公开(公告)日：2014-10-29
申请号：EP12808361.5
申请日：2012-12-17
发明人： HITCHCOCK, Marion , MENGEL, Anne , RICHTER, Anja , BRIEM, Hans , EIS, Knut , PÜTTER, Vera , SIEMEISTER, Gerhard , PRECHTL, Stefan , FERNÁNDEZ-MONTALVÁN, Amaury Ernesto , STEGMANN, Christian , HOLTON, Simon , GNOTH, Mark Jean , PREUSSE, Cornelia
IPC分类号： C07D401/14 , A61K31/4155 , A61P35/00
CPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
摘要翻译： 式（I）化合物及其作为药物的用途。
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公开(公告)号：EP3063138A1
公开(公告)日：2016-09-07
申请号：EP14789826.6
申请日：2014-10-27
发明人： MENGEL, Anne , RICHTER, Anja , HITCHCOCK, Marion , BRIEM, Hans , SIEMEISTER, Gerhard , BONE, Wilhelm , FERNÁNDEZ-MONTALVÁN, Amaury , SCHRÖDER, Jens , HOLTON, Simon , PREUSSE, Cornelia , MÖNNING, Ursula
IPC分类号： C07D401/14 , C07D403/14 , C07D417/14 , A61K31/4155 , A61K31/506 , A61K31/4439 , A61P35/00
CPC分类号： C07D417/14 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/14
摘要： Compounds of formula (I), processes for their preparation and their use as pharmaceuticals.
摘要翻译： 式（I）化合物，其制备方法及其作为药物的用途。
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6.发明授权SUBSTITUTED CYCLOALKENOPYRAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF CANCER 有权代入为CYCLOALKENOPYRAZOLE BUB1抑制剂用于癌症治疗
公开(公告)号：EP2847180B1
公开(公告)日：2017-01-04
申请号：EP13721755.0
申请日：2013-05-08
发明人： HITCHCOCK, Marion , HILGER, Christoph-Stephan , MENGEL, Anne , BRIEM, Hans , HOLTON, Simon , PÜTTER, Vera , SIEMEISTER, Gerhard , PRECHTL, Stefan , FERNÁNDEZ-MONTALVÁN, Amaury, Ernesto , STEGMANN, Christian , PREUSSE, Cornelia , GNOTH, Mark, Jean
IPC分类号： C07D403/04 , C07D403/14 , A61P35/00 , A61K31/506
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D403/04 , C07D405/14 , C07F7/1856 , C07F7/188
摘要： Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or disorders responsive to induction of cell death.
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公开(公告)号：EP2976336A1
公开(公告)日：2016-01-27
申请号：EP14714196.4
申请日：2014-03-20
发明人： HITCHCOCK, Marion , MENGEL, Anne , BRIEM, Hans , EIS, Knut , SIEMEISTER, Gerhard , BONE, Wilhelm , FERNÁNDEZ-MONTALVÁN, Amaury, Ernesto , SCHRÖDER, Jens , HOLTON, Simon , PREUSSE, Cornelia , PÜTTER, Vera
IPC分类号： C07D401/14 , A61K31/506 , C07D403/14 , C07D417/14 , C07D471/04 , A61P35/00
CPC分类号： C07D403/14 , A61K31/4439 , A61K31/506 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物，它们的制备方法和它们作为药物的用途。
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公开(公告)号：EP3010907A1
公开(公告)日：2016-04-27
申请号：EP14738399.6
申请日：2014-06-17
发明人： HILGER, Christoph-Stephan , HITCHCOCK, Marion , BRIEM, Hans , SIEMEISTER, Gerhard , FERNÁNDEZ-MONTALVÁN, Amaury Ernesto , SCHRÖDER, Jens , HOLTON, Simon , PREUSSE, Cornelia , DENNER, Karsten
IPC分类号： C07D401/14 , C07D403/14 , C07D498/04 , A61K31/506 , A61K31/53 , A61K31/5365 , A61P35/00
CPC分类号： C07D498/04 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/14
摘要： Compounds of formula (I), which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物，其生产方法及其作为药物的用途。
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9.发明公开SUBSTITUTED CYCLOALKENOPYRAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF CANCER 有权替代型环丙烯腈ALS BUB1-INHIBITOREN ZUR BEHANDLUNG VON KREBS
公开(公告)号：EP2847180A1
公开(公告)日：2015-03-18
申请号：EP13721755.0
申请日：2013-05-08
发明人： HITCHCOCK, Marion , HILGER, Christoph-Stephan , MENGEL, Anne , BRIEM, Hans , HOLTON, Simon , PÜTTER, Vera , SIEMEISTER, Gerhard , PRECHTL, Stefan , FERNÁNDEZ-MONTALVÁN, Amaury, Ernesto , STEGMANN, Christian , PREUSSE, Cornelia , GNOTH, Mark, Jean
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D403/04 , C07D405/14 , C07F7/1856 , C07F7/188
摘要： Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or disorders responsive to induction of cell death.
摘要翻译： 式（I）化合物，其生产方法及其作为Bub1激酶抑制剂用于治疗对诱导细胞死亡有反应的过度增殖性疾病和/或病症的用途。
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公开(公告)号：EP3010901B1
公开(公告)日：2017-09-13
申请号：EP14730544.5
申请日：2014-06-17
发明人： MENGEL, Anne , HITCHCOCK, Marion , RICHTER, Anja , BÄRFACKER, Lars , BRIEM, Hans , SIEMEISTER, Gerhard , BONE, Wilhelm , FERNÁNDEZ-MONTALVÁN, Amaury, Ernesto , SCHRÖDER, Jens , HOLTON, Simon , PREUSSE, Cornelia , MÖNNING, Ursula
IPC分类号： C07D401/14 , C07D413/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , A61K31/506 , A61K45/06 , C07D413/14
摘要： Compounds of formula (I), which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物，其生产方法及其作为药物的用途。
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