-
公开(公告)号：EP3526212A1
公开(公告)日：2019-08-21
申请号：EP17780751.8
申请日：2017-10-09
发明人： GIESE, Anja , KLAR, Jürgen , EHRMANN, Alexander Helmut Michael , WILLWACHER, Jens , ENGEL, David , DIESKAU, Andre Philippe , KAHNERT, Antje , GROMOV, Alexey , SCHMECK, Carsten , LINDNER, Niels , MÜLLER, Thomas , ANDREEVSKI, Anna Lena , DREHER, Jan , COLLINS, Karl
IPC分类号： C07D403/14 , C07D471/04 , C07D487/04 , C07D413/14 , A61K31/506 , A61K31/5377 , A61P13/12
-
公开(公告)号：EP3487856A1
公开(公告)日：2019-05-29
申请号：EP17742202.9
申请日：2017-07-10
发明人： DELBECK, Martina , HAHN, Michael , MÜLLER, Thomas , LUSTIG, Klemens , ANLAHR, Johanna , ALBUS, Udo , GEHRING, Doris , ROSENSTEIN, Björn , COLLINS, Karl , LINDNER, Niels , NICOLAI, Janine , BECK-BROICHSITTER, Moritz
IPC分类号： C07D471/08 , C07D498/08 , A61K31/439 , A61K31/5386 , A61P25/00
-
3.发明公开
公开(公告)号：EP3638676A1
公开(公告)日：2020-04-22
申请号：EP18733193.9
申请日：2018-06-07
发明人： DELBECK, Martina , HAHN, Michael , MÜLLER, Thomas , LUSTIG, Klemens , ANLAHR, Johanna , COLLINS, Karl , NICOLAI, Janine , BECK-BROICHSITTER, Moritz , ALBUS, Udo , GEHRING, Doris , ROSENSTEIN, Björn , DANG, Hongkai , DUAN, Dehe , YANG, Jianfei , CHEN, Denghui
IPC分类号： C07D471/18 , C07D487/04 , C07D487/18 , C07D498/18 , A61P11/00 , A61K31/551 , A61K31/5386
-
公开(公告)号：EP3692991A1
公开(公告)日：2020-08-12
申请号：EP19216135.4
申请日：2016-06-06
发明人： TELLER, Henrik , STRAUB, Alexander , BRECHMANN, Markus , MÜLLER, Thomas , MEININGHAUS, Mark , NOWAK-REPPEL, Katrin , TINEL, Hanna , MÜNTER, Klaus , FLIEGNER, Daniela , MONDRITZKI, Thomas , BOULTADAKIS ARAPINIS, Melissa , MARQUARDT, Tobias , VAKALOPOULOS, Alexandros , REBSTOCK, Anne-Sophie , WITTWER, Matthias
IPC分类号： A61K31/4375 , C07D471/04 , A61P9/06 , A61P13/12 , A61K31/4545 , A61K31/496 , A61K31/513 , A61K31/5377
摘要： Die vorliegende Anmeldung betrifft positiv allosterische Modulatoren des muskarinergen M2 Rezeptors, insbesondere solche, die gegenüber den verschiedenen muskarinergen Acetylcholin-Rezeptoren eine Subtyp-Selektivität für den M2-Rezeptor hinsichtlich der positiv-allosterischen Wirkung aufweisen, weiterhin deren Verwendung zur Behandlung und/oder Prävention von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prävention von Krankheiten, insbesondere zur Behandlung und/oder Prävention von kardiovaskulären Erkrankungen und/oder Nierenerkrankungen.
-
公开(公告)号：EP3172192A1
公开(公告)日：2017-05-31
申请号：EP15748189.6
申请日：2015-07-22
发明人： BUCHMANN, Bernd , HEISLER, Iring , MÜLLER, Thomas , CLEVE, Arwed , HÉROULT, Mélanie , NEUHAUS, Roland , PETRUL, Heike , QUANZ-SCHÖFFEL, Maria
IPC分类号： C07D401/12 , C07D401/14 , A61K31/4709 , A61K31/4748 , C07D231/38 , A61K31/415 , A61K31/4155 , A61P35/00 , C07D413/14 , C07D417/14
CPC分类号： C07D401/12 , A61K31/136 , A61K31/337 , A61K31/4709 , A61K31/513 , A61K31/555 , A61K31/573 , A61K31/675 , A61K31/704 , C07D215/50 , C07D231/38 , C07D401/06 , C07D401/14 , C07D403/06 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14 , A61K2300/00
摘要： The present invention relates to chemical compounds that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
摘要翻译： 本发明涉及选择性抑制葡萄糖转运蛋白1（GLUT1）的化合物，制备所述化合物的方法，包含所述化合物的药物组合物和组合，涉及所述化合物用于制备用于治疗或预防 疾病以及用于制备所述化合物的中间体化合物。
-
公开(公告)号：EP3083598A1
公开(公告)日：2016-10-26
申请号：EP14821117.0
申请日：2014-12-16
发明人： HEISLER, Iring , MÜLLER, Thomas , SIEBENEICHER, Holger , BUCHMANN, Bernd , CLEVE, Arwed , GÜNTHER, Judith , KOPPITZ, Marcus , HÉROULT, Mélanie , NEUHAUS, Roland , PETRUL, Heike , QUANZ-SCHÖFFEL, Maria
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D417/14 , C07D495/10 , A61K31/4709 , A61P35/00 , A61P37/00
CPC分类号： C07D401/12 , A61K31/4709 , A61K31/473 , A61K31/496 , A61K31/5377 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/10
摘要： The present invention relates to chemical compounds that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
摘要翻译： 本发明涉及选择性抑制葡萄糖转运蛋白1（GLUT1）的化合物，制备所述化合物的方法，药物组合物和包含所述化合物的组合，用于制备药物组合物用于治疗或预防 疾病，以及可用于制备所述化合物的中间体化合物。
-
公开(公告)号：EP3386993A1
公开(公告)日：2018-10-17
申请号：EP16805135.7
申请日：2016-12-02
发明人： DELBECK, Martina , HAHN, Michael , MÜLLER, Thomas , MEIER, Heinrich , LUSTIG, Klemens , MOSIG, Johanna , TOSCHI, Luisella , ALBUS, Udo , GEHRING, Doris , ROSENSTEIN, Björn
IPC分类号： C07D519/00 , A61K31/437 , A61P11/00
CPC分类号： C07D519/00
摘要： The invention relates to novel (2-phenylimidazo[1,2-a]pyridin-3-yl)methyl-substituted perhydropyrrolo[3,4-c]pyrrole derivatives, to methods for producing same, to the use thereof alone or in combination for the treatment and/or prevention of diseases, and to the use thereof for producing drugs for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of breathing disorders including sleep-related breathing disorders such as obstructive and central sleep apnea and snoring.
-
公开(公告)号：EP3194379A1
公开(公告)日：2017-07-26
申请号：EP15763619.2
申请日：2015-09-17
发明人： MENGEL, Anne , LERCHEN, Hans-Georg , MÖWES, Manfred , MÜLLER, Thomas , BÄRFACKER, Lars , HITCHCOCK, Marion , CLEVE, Arwed , KUHNKE, Joachim , BRIEM, Hans , SIEMEISTER, Gerhard , BONE, Wilhelm , FERNANDEZ-MONTALVAN, Amaury Ernesto , SCHRÖDER, Jens , MÖNNING, Ursula , HOLTON, Simon
IPC分类号： C07D401/14 , C07D403/14 , A61K31/506 , A61P35/00
CPC分类号： A61K31/506 , C07D401/14 , C07D403/14
摘要： Compounds of formula (I) as defined herein and their use as pharmaceuticals.
摘要翻译： 如本文所定义的式（I）化合物及其作为药物的用途。
-
公开(公告)号：EP3386979B1
公开(公告)日：2020-07-29
申请号：EP16808613.0
申请日：2016-12-07
发明人： DELBECK, Martina , HAHN, Michael , MÜLLER, Thomas , MEIER, Heinrich , LUSTIG, Klemens , MOSIG, Johanna , TOSCHI, Luisella , ALBUS, Udo , GEHRING, Doris , ROSENSTEIN, Björn
IPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61P11/00 , A61P11/16
-
10.发明公开
公开(公告)号：EP3307741A1
公开(公告)日：2018-04-18
申请号：EP16727193.1
申请日：2016-06-06
发明人： TELLER, Henrik , STRAUB, Alexander , BRECHMANN, Markus , MÜLLER, Thomas , MEININGHAUS, Mark , NOWAK-REPPEL, Katrin , TINEL, Hanna , MÜNTER, Klaus , FLIEGNER, Daniela , MONDRITZKI, Thomas , BOULTADAKIS ARAPINIS, Melissa , MARQUARDT, Tobias , VAKALOPOULOS, Alexandros , REBSTOCK, Anne-Sophie , WITTWER, Matthias, Beat
IPC分类号： C07D471/04 , A61K31/4375 , A61P9/06 , A61P13/12
摘要： The present application relates to positive allosteric modulators of the muscarinic M2 receptor, in particular novel 7-substituted 1-aryl-naphthyridin-3-carboxylic acid amides, to processes for the preparation thereof, to the use thereof alone or in combinations for the treatment and/or prevention of diseases, and to the use thereof for the production of medicaments for the treatment and/or prevention of diseases, particular for the treatment and/or prevention of cardiovascular disorders and/or renal diseases.
-
-
-
-
-
-
-
-
-
搜索结果
34 条记录 (耗时 0.04 秒)
