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1.发明公开POLYETHYLENE GLYCOL BASED PRODRUG OF ADRENOMEDULLIN AND USE THEREOF 有权ADRENOMEDULLIN-PRODRUG AUF POLYETHYLINGLYKOLBASIS UND VERWENDUNG DAVON
公开(公告)号：EP3075395A1
公开(公告)日：2016-10-05
申请号：EP15192265.5
申请日：2012-10-30
发明人： FLAMME, Ingo , KÖBBERLING, Johannes , LERCHEN, Hans-Georg , GRIEBENOW, Nils , SCHOHE-LOOP, Rudolf , WITTROCK, Sven , KÖLLNBERGER, Maria , WUNDER, Frank , REDLICH, Gordon , KNORR, Andreas , MARLEY, July , PRITCHARD, Iain
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates medicaments comprising novel polyethylene glycol (PEG) based prodrugs of Adrenomedullin, or one of the salts thereof, solvates thereof or the solvates of salts thereof, in combination with an inert nontoxic pharmaceutically suitable excipient, wherein the medicament is in a pharmaceutical form for inhalation, its use for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, to specific PEG-adrenomedullin prodrugs and its synthesis intermediates.
摘要翻译： 本发明涉及包含新型聚乙二醇（PEG）基于前体药物的肾上腺髓质素或其盐之一，其溶剂合物或其盐的溶剂合物与惰性无毒药学上合适的赋形剂组合的药物，其中药物为药物形式 用于吸入，其用于治疗和/或预防特定PEG-肾上腺髓质素前体药物及其合成中间体的疾病，特别是心血管，水肿和/或炎症性疾病的疾病。
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公开(公告)号：EP2773375A1
公开(公告)日：2014-09-10
申请号：EP12779063.2
申请日：2012-10-29
发明人： FLAMME, Ingo , KÖBBERLING, Johannes , LERCHEN, Hans-Georg , GRIEBENOW, Nils , SCHOHE-LOOP, Rudolf , WITTROCK, Sven , KRENZ, Ursula
CPC分类号： C07K5/0815 , A61K38/05 , A61K38/06 , A61K47/50 , A61K47/65 , C07K5/0215 , C07K5/06086
摘要： The invention relates to novel tyrosine based linkers that allow the releasable connection of peptides or proteins with other molecular entities, e.g. polyethylene glycol, to processes for their preparation and their use for preparing medicaments for the treatment and/or prophylaxis of diseases.
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3.发明授权TYROSINE BASED LINKERS FOR THE RELEASABLE CONNECTION OF PEPTIDES 有权TYROSINBASIERTE连接器ZURLÖSBARENVERBINDUNG VON PEPTIDEN
公开(公告)号：EP2773375B1
公开(公告)日：2017-02-08
申请号：EP12779063.2
申请日：2012-10-29
发明人： FLAMME, Ingo , KÖBBERLING, Johannes , LERCHEN, Hans-Georg , GRIEBENOW, Nils , SCHOHE-LOOP, Rudolf , WITTROCK, Sven , KRENZ, Ursula
CPC分类号： C07K5/0815 , A61K38/05 , A61K38/06 , A61K47/50 , A61K47/65 , C07K5/0215 , C07K5/06086
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公开(公告)号：EP3075395B1
公开(公告)日：2017-11-22
申请号：EP15192265.5
申请日：2012-10-30
发明人： FLAMME, Ingo , KÖBBERLING, Johannes , LERCHEN, Hans-Georg , GRIEBENOW, Nils , SCHOHE-LOOP, Rudolf , WITTROCK, Sven , KÖLLNBERGER, Maria , WUNDER, Frank , REDLICH, Gorden , KNORR, Andreas , MARLEY, July , PRITCHARD, Iain
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates medicaments comprising novel polyethylene glycol (PEG) based prodrugs of Adrenomedullin, or one of the salts thereof, solvates thereof or the solvates of salts thereof, in combination with an inert nontoxic pharmaceutically suitable excipient, wherein the medicament is in a pharmaceutical form for inhalation, its use for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, to specific PEG-adrenomedullin prodrugs and its synthesis intermediates.
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5.发明授权POLYETHYLENE GLYCOL BASED PRODRUG OF ADRENOMEDULLIN AND USE THEREOF 有权西班牙语VERWENDUNG的ADRENOMEDULLIN-PRODRUG AUF POLYETHYLINGLYKOLBASIS
公开(公告)号：EP2773376B1
公开(公告)日：2016-01-13
申请号：EP12783566.8
申请日：2012-10-30
发明人： FLAMME, Ingo , KÖBBERLING, Johannes , LERCHEN, Hans-Georg , GRIEBENOW, Nils , SCHOHE-LOOP, Rudolf , WITTROCK, Sven , KÖLLNBERGER, Maria , WUNDER, Frank , REDLICH, Gorden , KNORR, Andreas , MARLEY, July , PRITCHARD, Iain
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates medicaments comprising novel polyethylene glycol (PEG) based prodrugs of Adrenomedullin, or one of the salts thereof, solvates thereof or the solvates of salts thereof, in combination with an inert nontoxic pharmaceutically suitable excipient, wherein the medicament is in a pharmaceutical form for inhalation, its use for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, to specific PEG-adrenomedullin prodrugs and its synthesis intermediates.
摘要翻译： 本发明涉及包含新型聚乙二醇（PEG）基于前体药物的肾上腺髓质素或其盐之一，其溶剂化物或其盐的溶剂合物与惰性无毒药学上合适的赋形剂组合的药物，其中药物为药物形式 用于吸入，其用于治疗和/或预防特定PEG-肾上腺髓质素前体药物及其合成中间体的疾病，特别是心血管，水肿和/或炎症性疾病的疾病。
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公开(公告)号：EP2773376A1
公开(公告)日：2014-09-10
申请号：EP12783566.8
申请日：2012-10-30
发明人： FLAMME, Ingo , KÖBBERLING, Johannes , LERCHEN, Hans-Georg , GRIEBENOW, Nils , SCHOHE-LOOP, Rudolf , WITTROCK, Sven , KÖLLNBERGER, Maria , WUNDER, Frank , REDLICH, Gorden , KNORR, Andreas , MARLEY, July , PRITCHARD, Iain
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates medicaments comprising novel polyethylene glycol (PEG) based prodrugs of Adrenomedullin, or one of the salts thereof, solvates thereof or the solvates of salts thereof, in combination with an inert nontoxic pharmaceutically suitable excipient, wherein the medicament is in a pharmaceutical form for inhalation, its use for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, to specific PEG-adrenomedullin prodrugs and its synthesis intermediates.
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7.发明授权SUBSTITUIERTE BENZYL- UND PHENYLSULFONYLTRIAZOLONE UND IHRE VERWENDUNG 有权取代苄基和PHENYLSULFONYLTRIAZOLONE及其用途
公开(公告)号：EP2373632B1
公开(公告)日：2015-03-04
申请号：EP09756686.3
申请日：2009-11-26
发明人： BRÜGGEMEIER, UIf , FLAMME, Ingo , FÜRSTNER, Chantal , KELDENICH, Joerg , KOLKHOF, Peter , DELBECK, Martina , KRETSCHMER, Axel , POOK, Elisabeth , SCHMECK, Carsten , TRUEBEL, Hubert
IPC分类号： C07D249/12 , A61K31/4196 , A61P9/00
CPC分类号： C07D249/12
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8.发明授权SUBSTITUIERTE DIHYDROPYRAZOLONE ZUR BEHANDLUNG KARDIOVASKULÄRER UND HÄMATOLOGISCHER ERKRANKUNGEN 有权取代心血管疾病dihydropyrazolones和血液学的适应症的治疗
公开(公告)号：EP2084151B1
公开(公告)日：2013-05-29
申请号：EP07818948.7
申请日：2007-10-12
发明人： THEDE, Kai , FLAMME, Ingo , OEHME, Felix , ERGÜDEN, Jens-Kerim , STOLL, Friederike , SCHUHMACHER, Joachim , WILD, Hanno , KOLKHOF, Peter , BECK, Hartmut , KELDENICH, Jörg , AKBABA, Metin , JESKE, Mario
IPC分类号： C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , A61K31/41 , A61K31/435 , A61K31/495 , A61P7/00 , A61P9/00
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
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9.发明授权
公开(公告)号：EP2097404B1
公开(公告)日：2016-07-27
申请号：EP07819021.2
申请日：2007-10-16
发明人： THEDE, Kai , FLAMME, Ingo , OEHME, Felix , ERGÜDEN, Jens-Kerim , STOLL, Friederike , WILD, Hanno , KOLKHOF, Peter , BECK, Hartmut , JESKE, Mario
IPC分类号： C07D401/14 , A61K31/444 , A61P9/00
CPC分类号： C07D401/14
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10.发明授权5-ARYL-SUBSTITUIERTE DIHYDROPYRIDOPYRIMIDINE UND DIHYDROPYRIDAZINE UND IHRE VERWENDUNG ALS MINERALKORTICOIDANATGONISTEN 有权5-芳基取代的二氢吡啶并嘧啶类化合物和二氢哒嗪类化合物及其作为矿物质雄甾烷酸盐的用途
公开(公告)号：EP2035419B1
公开(公告)日：2016-06-22
申请号：EP07725586.7
申请日：2007-05-25
发明人： FIGUEROA PEREZ, Santiago , KOLKHOF, Peter , BÄRFACKER, Lars , FLAMME, Ingo , SCHLEMMER, Karl-Heinz , KUHL, Alexander , GROSSER, Rolf , MÜNTER, Klaus , KNORR, Andreas
IPC分类号： C07D471/04 , A61K31/519 , A61K31/5025 , A61P5/42 , A61P9/00
CPC分类号： C07D471/04
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