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1.发明授权NEW DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USES IN MANUFACTURES OF PHARMACEUTICAL MEDICAMENTS FOR TREATMENT AND PREVENTION AGAINST VIROSIS 有权新DIHYDROPYRMIDINVERBINDUNGEN和它们在药品生产用于治疗和有毒性防治方案
公开(公告)号：EP2135866B1
公开(公告)日：2014-07-02
申请号：EP08700582.3
申请日：2008-01-03
Inventor： LI, Song , ZHU, Xuejun , ZHAO, Guoming , WANG, Lili , ZHONG, Wu , ZHENG, Zhibing , XIAO, Junhai
IPC: C07D405/04 , C07D409/04 , A61P1/16 , A61K31/496
CPC classification number: C07D409/04 , C07D405/04
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2.发明公开OPTICAL PURE DIHYDROPYRIMIDINE COMPOUNDS, THEIR USES IN THE MANUFACTURE OF A MEDICAMNENT FOR THE TREATMENT OR THE PREVENTION OF VIROSIS DISEASES 有权光学纯DIHYDROPYRIMIDINVERBINDUNGEN及其用在药物中的用途，用于治疗或预防VIROSEKRANKHEITEN的
公开(公告)号：EP2048141A1
公开(公告)日：2009-04-15
申请号：EP07764007.6
申请日：2007-07-09
Inventor： LI, Song , XIA, Guangqiang , ZHAO, Guoming , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , ZHONG, Wu , XIAO, Junhai , LI, Xingzhou , CUI, Hao
IPC: C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , A61K31/4164 , A61K31/427 , A61K31/44 , A61K31/20
CPC classification number: C07D417/04 , C07D239/20 , C07D239/28
Abstract: The present invention relates to an optically pure compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, a process for preparing the optically pure compound of formula (I), and use of the optically pure compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.
Abstract translation: 本发明涉及式（I）或其药学上可接受的盐或水合物，其用于制备式（I）的光学纯的化合物的方法，以及使用式（I）的光学纯的化合物的光学纯的化合物或 药学上可接受的盐或水合物作为药物，特别是作为用于B型肝炎的治疗和预防药物。
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3.发明授权TETRAHYDROQUINAZOLINE COMPOUNDS AND THEIR USE IN PREPARING MEDICAMENTS FOR TREATING AND PREVENTING VIROSIS 有权TETRAHYDROCHINAZOLINVERBINDUNGEN和它们在药品生产用于治疗和有毒性防治方案
公开(公告)号：EP2119708B1
公开(公告)日：2013-08-14
申请号：EP08700583.1
申请日：2008-01-03
Inventor： LI, Song , ZHU, Xuejun , ZHAO, Guoming , WANG, Lili , ZHONG, Wu , ZHENG, Zhibing , XIAO, Junhai
IPC: C07D239/72 , A61K31/495 , A61P31/12
CPC classification number: C07D239/74 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D417/04
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4.发明授权DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USES IN PREPARATION OF MEDICAMENTS FOR TREATING AND PREVENTING ANTIVIRAL DISEASES 有权DIHYDROPYRIMIDINVERBINDUNGEN及其用途毒品生产用于治疗和预防疾病的抗病毒
公开(公告)号：EP2039686B1
公开(公告)日：2012-02-29
申请号：EP07764006.8
申请日：2007-07-09
Inventor： LI, Song , ZHAO, Guoming , XIA, Guangqiang , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , ZHONG, Wu , XIAO, Junhai , LI, Xingzhou , CUI, Hao
IPC: C07D417/04 , A61K31/506 , A61P31/12 , A61P1/16
CPC classification number: C07D239/20 , C07D403/04 , C07D417/04
Abstract: Compounds of formula I, their pharmaceutically acceptable salts or hydrates. Preparation methods of compounds of formula I and uses of compounds of formula I or their pharmaceutically acceptable salts or hydrates in preparation of medicaments, especially for treating and preventing hepatitis B agents.
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5.发明公开DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USES IN PREPARATION OF MEDICAMENTS FOR TREATING AND PREVENTING ANTIVIRAL DISEASES 有权DIHYDROPYRIMIDINVERBINDUNGEN及其用途毒品生产用于治疗和预防疾病的抗病毒
公开(公告)号：EP2039686A1
公开(公告)日：2009-03-25
申请号：EP07764006.8
申请日：2007-07-09
Inventor： LI, Song , ZHAO, Guoming , XIA, Guangqiang , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , ZHONG, Wu , XIAO, Junhai , LI, Xingzhou , CUI, Hao
IPC: C07D239/20 , C07D403/04 , C07D417/04 , A61K31/505 , A61K31/506 , A61P31/12 , A61P1/16
CPC classification number: C07D239/20 , C07D403/04 , C07D417/04
Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.
Abstract translation: 本发明涉及式（I）或其药学上可接受的盐或其水合物的化合物，一种用于制备式（I）的化合物，以及使用式（I）的化合物或其药学上可接受的盐的 或其水合物作为药物，特别是作为用于B型肝炎的治疗和预防药物。
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Patent Agency Ranking6.发明授权OPTICALLY PURE DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USES FOR THE PREPARATION OF A MEDICAMENT FOR TREATMENT AND PREVENTION OF VIRAL DISEASES. 有权光学纯二氢嘧啶化合物及其在制备用于治疗和预防病毒疾病的药物中的用途。
公开(公告)号：EP2048141B1
公开(公告)日：2017-06-14
申请号：EP07764007.6
申请日：2007-07-09
Inventor： LI, Song , XIA, Guangqiang , ZHAO, Guoming , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , ZHONG, Wu , XIAO, Junhai , LI, Xingzhou , CUI, Hao
IPC: C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , A61K31/4164 , A61K31/427 , A61K31/44 , A61K31/20 , A61P31/12 , C07D239/20 , A61K31/506
CPC classification number: C07D417/04 , C07D239/20 , C07D239/28
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7.发明公开NEW DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USES IN MANUFACTURES OF PHARMACEUTICAL MEDICAMENTS FOR TREATMENT AND PREVENTION AGAINST VIROSIS 有权新DIHYDROPYRMIDINVERBINDUNGEN和它们在药品生产用于治疗和有毒性防治方案
公开(公告)号：EP2135866A1
公开(公告)日：2009-12-23
申请号：EP08700582.3
申请日：2008-01-03
Inventor： LI, Song , ZHU, Xuejun , ZHAO, Guoming , WANG, Lili , ZHONG, Wu , ZHENG, Zhibing , XIAO, Junhai
IPC: C07D405/04 , C07D409/04 , A61P1/16 , A61K31/496
CPC classification number: C07D409/04 , C07D405/04
Abstract: The present invention relates to compounds of the formula (I) or pharmaceutically acceptable salts or hydrates thereof. The present invention further relates to processes for the preparation of the compounds of formula (I) and optical isomers and to use of the compounds of formula (I), isomers, pharmaceutically acceptable salts or hydrates thereof as medicaments, in particular as medicaments for the treatment and prevention of Hepatitis B.
Abstract translation: 本发明涉及式（I）或其药学上可接受的盐或它们的水合物的化合物。 本发明还涉及制备式（I）和光学异构体和化合物的制备式（I），异构体，药学上可接受的盐或水合物的化合物的其作为药物，特别是作为药物用于 治疗和预防乙肝
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8.发明授权ARENE CONNECTED POLYAMINE MACRORING DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF 有权ARENVERBUNDENE多胺微距环形衍生物，方法和药物使用了
公开(公告)号：EP2163553B1
公开(公告)日：2013-12-25
申请号：EP08772919.0
申请日：2008-05-30
Inventor： LI, Song , SU, Jing , LIU, Yao , XIAO, Junhai , WANG, Lili , ZHONG, Wu , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHAO, Guoming , WANG, Xiaokui , ZHOU, Xinbo , LIU, Hongying
IPC: C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14 , A61K31/395 , A61K31/435 , A61K31/4155 , A61K31/559 , A61K31/4178 , A61K31/41 , A61K31/427 , A61P31/18
CPC classification number: C07D471/08 , C07D255/04 , C07D257/02 , C07D401/10
Abstract: Abstract: The present invention relates to arene connected polyamine macrocyclic derivatives represented by general formula I, pharmaceutically acceptable salts or hydrates thereof which have anti-HIV activities, in which the definitions of substituents are as defined in the description; to preparation methods of the compounds of formula I; to pharmaceutical compositions containing the compounds of formula I or their pharmaceutically acceptable salts or hydrates; to the use of the compounds of formula I or their pharmaceutically acceptable salts or hydrates for the preparation of a medicament for the treatment and prevention of HIV-associated diseases.
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9.发明公开
公开(公告)号：EP2163553A1
公开(公告)日：2010-03-17
申请号：EP08772919.0
申请日：2008-05-30
Inventor： LI, Song , SU, Jing , LIU, Yao , XIAO, Junhai , WANG, Lili , ZHONG, Wu , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHAO, Guoming , WANG, Xiaokui , ZHOU, Xinbo , LIU, Hongying
IPC: C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14 , A61K31/395 , A61K31/435 , A61K31/4155 , A61K31/559 , A61K31/4178 , A61K31/41 , A61K31/427 , A61P31/18
CPC classification number: C07D471/08 , C07D255/04 , C07D257/02 , C07D401/10
Abstract: Abstract: The present invention relates to arene connected polyamine macrocyclic derivatives represented by general formula I, pharmaceutically acceptable salts or hydrates thereof which have anti-HIV activities, in which the definitions of substituents are as defined in the description; to preparation methods of the compounds of formula I; to pharmaceutical compositions containing the compounds of formula I or their pharmaceutically acceptable salts or hydrates; to the use of the compounds of formula I or their pharmaceutically acceptable salts or hydrates for the preparation of a medicament for the treatment and prevention of HIV-associated diseases.
Abstract translation: 摘要：本发明涉及具有抗HIV活性的由通式I表示的芳族连接的多胺大环衍生物，其药学上可接受的盐或水合物，其中取代基的定义如说明书中所定义; 涉及式I化合物的制备方法; 包含式I化合物或其药学上可接受的盐或水合物的药物组合物; 涉及使用式I化合物或其药学上可接受的盐或水合物来制备用于治疗和预防HIV相关疾病的药物。
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10.发明公开TETRAHYDROQUINAZOLINE COMPOUNDS AND THEIR USE IN PREPARING MEDICAMENTS FOR TREATING AND PREVENTING VIROSIS 有权TETRAHYDROCHINAZOLINVERBINDUNGEN和它们在药品生产用于治疗和有毒性防治方案
公开(公告)号：EP2119708A1
公开(公告)日：2009-11-18
申请号：EP08700583.1
申请日：2008-01-03
Inventor： LI, Song , ZHU, Xuejun , ZHAO, Guoming , WANG, Lili , ZHONG, Wu , ZHENG, Zhibing , XIAO, Junhai
IPC: C07D239/72 , A61K31/495 , A61P31/12
CPC classification number: C07D239/74 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D417/04
Abstract: The present invention relates to a compound of formula (I) or isomers thereof, or pharmaceutically acceptable salts or hydrates thereof. The present invention further relates to processes for the preparation of the compounds of formula (I) and optical isomers, and to the use of the compounds of formula (I), or isomers thereof, or pharmaceutically acceptable salts or hydrates thereof as medicaments, in particular as medicaments for the treatment and prevention of Hepatitis B.
Abstract translation: 本发明涉及式（I）或异构体的化合物，或其药学上可接受的盐或它们的水合物。 本发明还涉及式（I）和光学异构体的化合物的制备方法，并涉及其作为药物，在使用式（I）或异构体的其化合物或其药学上可接受的盐或水合物的 特别是用作治疗乙肝的治疗和预防
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