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公开(公告)号：EP2768307B1
公开(公告)日：2020-03-18
申请号：EP12841572.6
申请日：2012-10-19
发明人： GARVEY, david, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, R. , FRYE, Leah, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
IPC分类号： A01N43/38 , C07C69/75 , C07C233/58 , C07C49/553 , C07C49/443
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公开(公告)号：EP2785178B1
公开(公告)日：2019-05-01
申请号：EP12852566.4
申请日：2012-11-29
发明人： QUACH, Tan , BERMAN, Judd , GARVEY, David, S.
IPC分类号： C07C255/54 , C07C255/58 , C07C33/50 , C07D317/46 , C07D317/64 , C07D317/66 , C07C43/215 , C07C43/225 , C07C211/45 , C07C211/52 , C07C217/84 , C07C323/09 , C07C237/30 , A61K31/137 , A61P27/02
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3.发明公开OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE 审中-公开OPSINBINDENDE LIGANDEN，ZUSAMMENSETZUNGEN UND VERFAHREN ZUR VERWENDUNG
公开(公告)号：EP3100723A1
公开(公告)日：2016-12-07
申请号：EP16177507.7
申请日：2010-06-16
发明人： GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, Robert , BREWER, Mark, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
IPC分类号： A61K31/11 , A61P27/02 , C07D207/12 , C07D207/14 , C07D243/08 , C07D491/10 , C07D493/08
CPC分类号： C07D295/215 , C07B59/002 , C07B2200/05 , C07C233/10 , C07C275/14 , C07C2601/16 , C07D205/04 , C07D207/12 , C07D207/14 , C07D211/38 , C07D241/04 , C07D241/08 , C07D243/08 , C07D295/182 , C07D295/185 , C07D295/194 , C07D295/205 , C07D295/26 , C07D491/10 , C07D493/08
摘要： Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in these methods, either alone or in combination with other therapeutic agents, are also described.
摘要翻译： 公开了所述化合物的化合物和组合物以及化合物的使用方法，用于治疗与视蛋白蛋白质错位定位相关的眼科疾病，突变视蛋白蛋白质的错误折叠以及积聚在眼睛中的毒性视觉循环产物的产生。 还描述了可用于这些方法中的单独或与其它治疗剂组合的化合物和组合物。
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4.发明授权OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE 有权OPSINBINDENDE LIGANDEN SOWIE ZUSAMMENSETZUNGEN DARAUS UND VERWENDUNGSVERFAHRENDAFÜR
公开(公告)号：EP2442644B1
公开(公告)日：2016-08-10
申请号：EP10789866.0
申请日：2010-06-16
发明人： GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, Robert , BREWER, Mark, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
IPC分类号： A61K31/11 , A61P27/02 , C07D207/12 , C07D207/14 , C07D243/08 , C07D491/10 , C07D493/08
CPC分类号： C07D295/215 , C07B59/002 , C07B2200/05 , C07C233/10 , C07C275/14 , C07C2601/16 , C07D205/04 , C07D207/12 , C07D207/14 , C07D211/38 , C07D241/04 , C07D241/08 , C07D243/08 , C07D295/182 , C07D295/185 , C07D295/194 , C07D295/205 , C07D295/26 , C07D491/10 , C07D493/08
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公开(公告)号：EP2785178A1
公开(公告)日：2014-10-08
申请号：EP12852566.4
申请日：2012-11-29
发明人： QUACH, Tan , BERMAN, Judd , GARVEY, David, S.
IPC分类号： A01N35/00
CPC分类号： C07C211/52 , C07C33/50 , C07C43/215 , C07C43/225 , C07C49/237 , C07C49/813 , C07C211/45 , C07C211/46 , C07C217/84 , C07C237/30 , C07C255/54 , C07C255/58 , C07C255/59 , C07C323/09 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D317/46 , C07D317/64 , C07D317/66
摘要： Compounds and compositions are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
摘要翻译： 公开了化合物和组合物，所述化合物和组合物用于治疗由眼部积聚的毒性视觉周期产物（例如干性成人黄斑变性）引起的或与眼部疾病有关的眼科疾病，以及由突变视蛋白错误折叠引起的或与错误折叠有关的疾病 蛋白质和/或视蛋白蛋白质的错误定位。 还描述了单独或与其他治疗剂组合的这些化合物的组合物以及使用这些化合物和/或组合物的治疗方法。 还公开了合成这些试剂的方法。
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公开(公告)号：EP3100723B1
公开(公告)日：2019-06-12
申请号：EP16177507.7
申请日：2010-06-16
发明人： GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, Robert , BREWER, Mark, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
IPC分类号： A61K31/11 , A61P27/02 , C07D207/12 , C07D207/14 , C07D243/08 , C07D491/10 , C07D493/08
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公开(公告)号：EP2768307A1
公开(公告)日：2014-08-27
申请号：EP12841572.6
申请日：2012-10-19
发明人： GARVEY, david, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, R. , FRYE, Leah, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
IPC分类号： A01N43/38
CPC分类号： C07D307/83 , C07C35/32 , C07C49/443 , C07C49/553 , C07C69/75 , C07C233/58 , C07C251/44 , C07C2602/24 , C07D209/34 , C07D209/46
摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic is visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
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公开(公告)号：EP2442644A1
公开(公告)日：2012-04-25
申请号：EP10789866.0
申请日：2010-06-16
发明人： GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, Robert , BREWER, Mark, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
CPC分类号： C07D295/215 , C07B59/002 , C07B2200/05 , C07C233/10 , C07C275/14 , C07C2601/16 , C07D205/04 , C07D207/12 , C07D207/14 , C07D211/38 , C07D241/04 , C07D241/08 , C07D243/08 , C07D295/182 , C07D295/185 , C07D295/194 , C07D295/205 , C07D295/26 , C07D491/10 , C07D493/08
摘要： Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.
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