公开(公告)号：EP1778721B1

公开(公告)日：2008-04-09

申请号：EP05793254.3

申请日：2005-07-27

申请人： Bio-Rad Pasteur

发明人： GADELLE, Stéphane ,  RIEUNIER, François

IPC分类号： C07K14/16 ,  C07K16/10 ,  G01N33/569

CPC分类号： C07K14/005 ,  C12N2740/16122 ,  G01N33/56988 ,  G01N2469/20

摘要： The invention relates to synthetic peptides having sequence (III), which are derived from HIV-1 virus gp41 and which can be used in immunoassays for the detection of infections caused by HIV-1 viruses. The invention also relates to the method of preparing said peptides, to compositions and kits containing same and to the use thereof for diagnostic purposes. The invention further relates to immunoassays which use said peptides for the detection of anti-HIV virus antibodies.

公开(公告)号：EP1527101A2

公开(公告)日：2005-05-04

申请号：EP03756532.2

申请日：2003-08-07

申请人： Bio-Rad Pasteur ,  CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) ,  Université Montpellier I

发明人： PAU, Bernard ,  GIULIANI, Isabelle ,  RIEUNIER, François

IPC分类号： C07K16/26 ,  C12N5/12 ,  G01N33/53 ,  C07K7/06 ,  C07K7/08 ,  C07K16/06 ,  G01N33/74 ,  C12N5/20

CPC分类号： C07K16/26 ,  C07K14/58 ,  C07K2317/34

摘要： The invention relates to in vitro diagnosis of heart failure. More specifically, the invention relates to specific antibodies of a peptide domain which is situated on either side of hinge region R76S77 of proBNP(1-108). In particular, the invention relates to a method of obtaining the aforementioned antibodies and to the use thereof in detecting blood proBNP(1-108) with the exception of BNP(1-76) and BNP(77-108). The invention also relates to a method of detecting blood proBNP(1-108), reagents and a kit for same.

公开(公告)号：EP1527101B1

公开(公告)日：2010-10-27

申请号：EP03756532.2

申请日：2003-08-07

申请人： Bio-Rad Pasteur ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Université Montpellier I

发明人： PAU, Bernard ,  GIULIANI, Isabelle ,  RIEUNIER, François

IPC分类号： C07K16/26 ,  C12N5/12 ,  G01N33/53 ,  C07K7/06 ,  C07K7/08 ,  C07K16/06 ,  G01N33/74 ,  C12N5/20

CPC分类号： C07K16/26 ,  C07K14/58 ,  C07K2317/34

公开(公告)号：EP2170940A1

公开(公告)日：2010-04-07

申请号：EP08786803.0

申请日：2008-08-01

申请人： Bio-Rad Pasteur ,  Centre National de la Recherche Scientifique (CNRS)

发明人： RIEUNIER, François ,  GIULIANI, Isabelle ,  VILLARD-SAUSSINE, Sylvie

IPC分类号： C07K14/58 ,  G01N33/68

CPC分类号： G01N33/74 ,  C07K14/58 ,  G01N2333/58 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/50 ,  G01N2800/52

摘要： The present invention relates to a polypeptide carrying a human BNP(I -32) epitope according to Formula (I): a1-R1-X1-FGRKMDR-X2-R2-a2 as well as ligands specific of the FGRKMDR epitope.

公开(公告)号：EP1504266A2

公开(公告)日：2005-02-09

申请号：EP03749938.1

申请日：2003-05-09

申请人： Bio-Rad Pasteur

发明人： RIEUNIER, François ,  FEYSSAGUET, Muriel ,  HENRIOT, Stéphanie ,  LAMBERT, Nadine

IPC分类号： G01N33/569 ,  G01N33/576 ,  C07K14/18

CPC分类号： C07K14/1833 ,  C07K14/005 ,  C07K14/161 ,  C07K16/109 ,  C07K16/42 ,  C07K2317/32 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2770/24222 ,  G01N33/569 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/5767 ,  G01N2333/16 ,  G01N2333/18

摘要： The invention concerns a method for in vitro detection of an infection mediated by a microorganism, such as the hepatitis C virus, in a biological sample, by simultaneous detection of an antigen of said microorganism and antibodies directed against said antigen, as well as reagents and kits for implementing said method.

公开(公告)号：EP1247096B1

公开(公告)日：2005-03-30

申请号：EP01903931.2

申请日：2001-01-12

申请人： Bio-Rad Pasteur

发明人： BABIN, Fabienne ,  HAMON, Laurence ,  RIEUNIER, François

IPC分类号： G01N33/544

CPC分类号： G01N33/54393

公开(公告)号：EP2076610A2

公开(公告)日：2009-07-08

申请号：EP07848809.5

申请日：2007-10-12

申请人： Bio-Rad Pasteur

发明人： DAGLAND, Typhaine ,  RIEUNIER, François

IPC分类号： C12Q1/68

CPC分类号： C12Q1/706 ,  C12Q1/6818 ,  C12Q1/6844 ,  C12Q1/703 ,  Y02A50/59 ,  C12Q2565/525 ,  C12Q2537/161 ,  C12Q2525/161 ,  C12Q2561/12 ,  C12Q2561/113 ,  C12Q2531/113

摘要： The present invention relates to a double-stranded probe intended for the fluorescent detection of at least one single-stranded or double-stranded target nucleic acid, comprising: - a first strand of formula X 1 -(L 1 ) a -S 1 -S' 1 -(L' 1 ) b -Y 1 intended for the detection of a first strand of the target nucleic acid which comprises a sequence of formula T' 1 -T 1 ; - a second strand of formula X 2 -(L 2 ) c -S 2 -S' 2 -(L' 2 ) d -Y 2 intended for the detection of a second strand of the target nucleic acid, if present, said second strand of the target nucleic acid comprising a sequence of formula T' 2 -T 2 ; wherein two of X 1 , X 2 , Y 1 , and Y 2 represent a fluorescent donor, while the two others represent a fluorescent acceptor, and X 1 and Y 2 can not both represent a fluorescent donor.

公开(公告)号：EP1247096A1

公开(公告)日：2002-10-09

申请号：EP01903931.2

申请日：2001-01-12

申请人： Bio-Rad Pasteur

发明人： BABIN, Fabienne ,  HAMON, Laurence ,  RIEUNIER, François

IPC分类号： G01N33/544

CPC分类号： G01N33/54393

摘要： The invention relates to a method for the immobilisation of (an) affinity reagent(s) on a hydrophobic solid phase and can be used in biological assays for analyte detection. In particular, the invention relates to a method of immobilising an affinity reagent on a hydrophobic solid phase with a carboxylic functionality, comprising a solid phase activation step and a solid phase and affinity reagent coupling step. Said method is characterised in that a combination of a carbodiimide and a phosphate buffer is used for the activation step in the presence of a co-activator and in an acid medium and that the coupling step is carried out in a basic medium. The invention further relates to the reactive complexes obtained by said method and their use in immunoassay kits, hybridisation kits and enzymatic test kits.