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公开(公告)号：EP3954383A1
公开(公告)日：2022-02-16
申请号：EP21191307.4
申请日：2016-02-09
申请人： BioNTech SE , TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GGMBH
发明人： SAHIN, Ugur , LÖWER, Martin , TADMOR, Arbel D. , BOEGEL, Sebastian , SCHRÖRS, Barbara , VORMEHR, Mathias , KREITER, Sebastian
摘要： The present invention relates to methods for predicting T cell epitopes useful for vaccination. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic and, in particular, useful for vaccination, or for predicting which of such modifications are most immunogenic and, in particular, most useful for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and thus, in the context of personalized cancer vaccines.
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公开(公告)号：EP3881827A1
公开(公告)日：2021-09-22
申请号：EP21165536.0
申请日：2017-07-14
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GGMBH
发明人： SAHIN, Ugur , HAAS, Heinrich , VOGEL, Annette , ZUCKER, Daniel , ERBAR, Stephanie , REUTER, Kerstin , SCHLEGEL, Anne , HÖRNER, Sebastian , KREITER, Sebastian , DIKEN, Mustafa , MORENO HERRERO, Jorge
摘要： The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine. The RNA may encode a protein of interest, such as a pharmaceutically active protein. Furthermore, the present invention relates to pharmaceutical products, comprising said RNA polyplex formulations for parenteral application to humans or to animals. The present invention relates as well to manufacturing of such pharmaceutical products, comprising, optionally, steps of sterile filtration, freezing and dehydration.
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公开(公告)号：EP3359563B8
公开(公告)日：2019-10-02
申请号：EP16777681.4
申请日：2016-10-05
申请人： BIONTECH CELL & GENE THERAPIES GMBH , TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GGMBH
IPC分类号： C07K14/725 , C07K16/28
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公开(公告)号：EP3617226A1
公开(公告)日：2020-03-04
申请号：EP19187303.3
申请日：2016-10-05
申请人： BIONTECH CELL & GENE THERAPIES GMBH , TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GGMBH
IPC分类号： C07K14/725 , C07K16/28
摘要： The present invention generally embraces the treatment of diseases by targeting cells expressing an antigen on the cell surface. In particular the invention relates to recombinant antigen receptors and uses thereof. T cells engineered to express such antigen receptors are useful in the treatment of diseases characterized by expression of one or more antigens bound by the antigen receptors.
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公开(公告)号：EP4444342A1
公开(公告)日：2024-10-16
申请号：EP22834951.0
申请日：2022-12-08
申请人： BioNTech SE
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公开(公告)号：EP4413040A1
公开(公告)日：2024-08-14
申请号：EP22802904.7
申请日：2022-10-05
申请人： Genmab A/S , BioNTech SE
发明人： MUIK, Alexander , NÜRMBERGER, Kristina , PENCHEVA, Nora , JURE-KUNKEL, Maria,N, , SAHIN, Ugur , FELLERMEIER-KOPF, Sina , GARRIDO CASTRO, Patricia , BLUM, Jordan , GIESEKE, Friedericke , BREIJ, Esther C. W. , GUELEN, Lars , NEIJSSEN, Joost , BECKMANN, Karsten , PAULMANN, Claudia , DE KREUK, Bart-Jan , HIBBERT, Richard , SCHUURMAN, Janine , LABRIJN, Aran , KUZMANOV, Ivan
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公开(公告)号：EP4370551A1
公开(公告)日：2024-05-22
申请号：EP22750715.9
申请日：2022-07-13
申请人： BioNTech SE
发明人： SAHIN, Ugur , STADLER, Christiane , LINDEMANN, Claudia , ELLINGHAUS, Ursula , BÄHR-MAHMUD, Hayat , FISCHER, Leyla , CHATURVEDI, Anuhar , BOROS, Gábor , REINHOLZ, Jonas , BESSONOV, Sergey , KARIKÓ, Katalin
CPC分类号： C07K16/2809 , C07K16/28 , C07K2317/3120130101 , A61P35/00 , C07K2317/62220130101
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公开(公告)号：EP4359435A1
公开(公告)日：2024-05-01
申请号：EP22735846.2
申请日：2022-06-20
申请人： Genmab A/S , BioNTech SE
发明人： SAHIN, Ugur , MUIK, Alexander , FORSSMANN, Ulf , JURE-KUNKEL, Maria N. , BAJAJ, Gaurav , TALHAUSER, Craig , PENCHEVA, Nora
CPC分类号： C07K16/24 , C07K16/2827 , A61K2039/54520130101 , C07K2317/73420130101
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公开(公告)号：EP4326317A1
公开(公告)日：2024-02-28
申请号：EP22720733.9
申请日：2022-04-20
申请人： BioNTech SE
发明人： SAHIN, Ugur , MUIK, Alexander
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公开(公告)号：EP4162034A1
公开(公告)日：2023-04-12
申请号：EP21729331.5
申请日：2021-06-01
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： PERKOVIC, Mario , WITZEL, Sonja , BEISSERT, Tim , SAHIN, Ugur
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