公开(公告)号：EP1926556A2

公开(公告)日：2008-06-04

申请号：EP06803857.9

申请日：2006-09-19

申请人： Biomerieux, Inc.

发明人： COLIN, Bruno ,  BAEYAERT, Sylvain ,  RONSICK, Chris ,  WILSON, Mark ,  ROBINSON, Ron

IPC分类号： B01L3/14

CPC分类号： B65D51/241 ,  B01L3/50825 ,  B01L2300/042 ,  B01L2300/048 ,  B01L2300/049 ,  B65D39/0005 ,  B65D41/16 ,  B65D45/322

摘要： Embodiments of the present invention include a specimen enclosure apparatus . The specimen enclosure apparatus includes a container having a cavity configured to receive the specimen and an opening extending through a neck of the container to the cavity. An internal flange is positioned intermediate the neck (406) of the container. The specimen enclosure apparatus further includes a closure device (200a) configured to be received in the opening. The closure device has a flange seal portion configured to contact the internal flange to form a flange seal proximate the cavity and further has a radial travel limiter integrally formed with the closure device that is configured to contact the container in the opening to limit radial movement of the flange seal portion relative to the internal flange. Containers and closure devices are also provided.

公开(公告)号：EP1146963B1

公开(公告)日：2005-03-02

申请号：EP00968466.3

申请日：2000-09-29

申请人： Biomerieux, Inc.

发明人： KLUTTZ, Brian ,  McKINLEY, Geoff, A. ,  GENNARI, Fabio ,  GUY, Michel ,  COTTER, Christopher ,  CATANZARITI, Luigi ,  GRAZIANO, Louis ,  COLIN, Bruno ,  PARIS, Cécile ,  DACHAUD, Jacques

IPC分类号： B01L7/00 ,  B01L3/00

CPC分类号： C12Q1/6848 ,  B01L3/502 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/026 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0809 ,  B01L2300/0825 ,  B01L2300/0861 ,  B01L2300/087 ,  B01L2300/1822 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/0633 ,  B01L2400/0644 ,  B01L2400/0655 ,  G01N35/026 ,  G01N2035/0436

摘要： An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification reagent (e.g., primers and nucleotides) and a second reaction chamber either containing, or in fluid communication, with a second nucleic acid amplification reagent (e.g., an amplification enzyme such as RT). The instrument includes a support structure receiving the test device. A temperature control system maintains the first reaction chamber at a first elevated temperature but simultaneously maintains the second nucleic acid amplification reagent at a second temperature lower than the first temperature so as to preserve the second nucleic acid amplification reagent. An actuator operates on a fluid conduit in the test device to place the first and second reaction chambers in fluid communication with each other after a reaction has occurred in the first reaction chamber at the first temperature. A pneumatic system is also provided that assists in fluid transfer of a reaction solution from the first chamber to the second chamber.

公开(公告)号：EP2625531A2

公开(公告)日：2013-08-14

申请号：EP11831584.5

申请日：2011-10-06

申请人： Biomerieux, Inc

发明人： COLIN, Bruno ,  O'BEAR, Raymond ,  PARIS, Cecile

IPC分类号： G01N35/00 ,  C12M3/00 ,  C12M1/22 ,  C12M1/34

CPC分类号： B01L3/5025 ,  B01L3/502723 ,  B01L3/523 ,  B01L3/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/141 ,  B01L2200/143 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0893 ,  B01L2400/049

摘要： The present invention is directed to sample test cards having an increased sample well capacity for analyzing biological or other test samples. In one embodiment, the sample test cards of the present invention comprise one or more fluid over-flow reservoirs, wherein the over-flow reservoirs are operatively connected to a distribution channel by a fluid over-flow channel. In another embodiment, the sample test cards may comprise a plurality of flow reservoirs operable to trap air thereby reducing and/or preventing well-to-well contamination. The test card of this invention may comprise from 80 to 140 individual sample wells, for example, in a test card sample test cards of the present invention have a generally rectangular shape sample test card having dimensions of from about 90 to about 95 mm in width, from about 55 to about 60 mm in height and from about 4 to about 5 mm in thickness.

摘要翻译： 本发明涉及具有增加的样品孔容量的样品测试卡，用于分析生物或其他测试样品。 在一个实施例中，本发明的样本测试卡包括一个或多个流体溢流储存器，其中溢流储存器通过流体溢流通道可操作地连接到分配通道。 在另一个实施例中，样本测试卡可以包括多个可操作用于捕集空气从而减少和/或防止井至污染的流动储存器。 本发明的测试卡可以包括80至140个单独的样品孔，例如，在测试卡样品中，本发明的测试卡具有大致矩形形状的样品测试卡，其尺寸为约90至约95mm的宽度 约55至约60mm的高度和约4至约5mm的厚度。

公开(公告)号：EP1146961B1

公开(公告)日：2007-09-05

申请号：EP00967055.5

申请日：2000-09-29

申请人： Biomerieux, Inc.

发明人： KLUTTZ, Brian ,  BURG, Lawrence ,  TEGELER, Garry ,  GRAZIANO, Louis ,  COTTER, Christopher ,  GUY, Michel ,  GREER, James ,  MCKINLEY, Geoff, A. ,  CATANZARITI, Luigi ,  GLASSFORD, Robert ,  BISHOP, James, Clement ,  COLIN, Bruno ,  PARIS, Cecile ,  WANG, Thomas ,  MORIN, Michael

IPC分类号： B01L3/00

CPC分类号： B01L7/52 ,  B01L3/502 ,  B01L2200/026 ,  B01L2300/0825 ,  B01L2300/0861 ,  B01L2400/049 ,  B01L2400/0644 ,  B01L2400/0655 ,  G01N2035/00366

摘要： A unit dose test device for a nucleic acid amplification reaction has the form of an elongate disposable test strip. The test strip includes a dual-chamber reaction vessel preloaded with nucleic acid amplication reaction agents, a plurality of wells for processing a reaction occuring in the reaction vessel, and a hinge cover above a membrane, sealing both reaction chambers. A desiccant is loaded in proximity to and in communication with first or second reaction chamber.

公开(公告)号：EP1146963A1

公开(公告)日：2001-10-24

申请号：EP00968466.3

申请日：2000-09-29

申请人： Biomerieux, Inc.

发明人： KLUTTZ, Brian ,  McKINLEY, Geoff, A. ,  GENNARI, Fabio ,  GUY, Michel ,  COTTER, Christopher ,  CATANZARITI, Luigi ,  GRAZIANO, Louis ,  COLIN, Bruno ,  PARIS, Cécile ,  DACHAUD, Jacques

IPC分类号： B01L7/00 ,  B01L3/00

CPC分类号： C12Q1/6848 ,  B01L3/502 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/026 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0809 ,  B01L2300/0825 ,  B01L2300/0861 ,  B01L2300/087 ,  B01L2300/1822 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/0633 ,  B01L2400/0644 ,  B01L2400/0655 ,  G01N35/026 ,  G01N2035/0436

摘要： An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification reagent (e.g., primers and nucleotides) and a second reaction chamber either containing, or in fluid communication, with a second nucleic acid amplification reagent (e.g., an amplification enzyme such as RT). The instrument includes a support structure receiving the test device. A temperature control system maintains the first reaction chamber at a first elevated temperature but simultaneously maintains the second nucleic acid amplification reagent at a second temperature lower than the first temperature so as to preserve the second nucleic acid amplification reagent. An actuator operates on a fluid conduit in the test device to place the first and second reaction chambers in fluid communication with each other after a reaction has occurred in the first reaction chamber at the first temperature. A pneumatic system is also provided that assists in fluid transfer of a reaction solution from the first chamber to the second chamber.

公开(公告)号：EP2321402B1

公开(公告)日：2017-07-12

申请号：EP09788768.1

申请日：2009-05-13

申请人： Biomerieux, Inc

发明人： COLIN, Bruno ,  IAKIMOVA, Yaneli ,  KETSENBURG, Kevin, G. ,  ROBBINS, David, M. ,  BELLET, Stephane

IPC分类号： C12M1/22 ,  C12M1/20 ,  B01L9/00

CPC分类号： C12M23/48 ,  C12M23/10 ,  G01N35/04 ,  G01N2035/042 ,  G01N2035/0425

公开(公告)号：EP1146961A1

公开(公告)日：2001-10-24

申请号：EP00967055.5

申请日：2000-09-29

申请人： Biomerieux, Inc.

发明人： KLUTTZ, Brian ,  BURG, Lawrence ,  TEGELER, Garry ,  GRAZIANO, Louis ,  COTTER, Christopher ,  GUY, Michel ,  GREER, James ,  MCKINLEY, Geoff, A. ,  CATANZARITI, Luigi ,  GLASSFIELD, Robert ,  BISHOP, James, Clement ,  COLIN, Bruno ,  PARIS, Cecile ,  WANG, Thomas ,  MORIN, Michael

IPC分类号： B01L3/00

CPC分类号： B01L7/52 ,  B01L3/502 ,  B01L2200/026 ,  B01L2300/0825 ,  B01L2300/0861 ,  B01L2400/049 ,  B01L2400/0644 ,  B01L2400/0655 ,  G01N2035/00366

摘要： A unit dose test device for a nucleic acid amplification reaction has the form of an elongate disposable test strip. The test strip includes a dual-chamber reaction vessel preloaded with nucleic acid amplication reaction agents, a plurality of wells for processing a reaction occuring in the reaction vessel, and a hinge cover above a membrane, sealing both reaction chambers. A desiccant is loaded in proximity to and in communication with first or second reaction chamber.

公开(公告)号：EP2625531B1

公开(公告)日：2018-12-12

申请号：EP11831584.5

申请日：2011-10-06

申请人： Biomerieux, Inc

发明人： COLIN, Bruno ,  O'BEAR, Raymond ,  PARIS, Cecile

IPC分类号： G01N35/00 ,  C12M3/00 ,  C12M1/22 ,  C12M1/34 ,  B01L3/00

CPC分类号： B01L3/5025 ,  B01L3/502723 ,  B01L3/523 ,  B01L3/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/141 ,  B01L2200/143 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0893 ,  B01L2400/049

摘要： The present invention is directed to sample test cards having an increased sample well capacity for analyzing biological or other test samples. In one embodiment, the sample test cards of the present invention comprise one or more fluid over-flow reservoirs, wherein the over-flow reservoirs are operatively connected to a distribution channel by a fluid over-flow channel. In another embodiment, the sample test cards may comprise a plurality of flow reservoirs operable to trap air thereby reducing and/or preventing well-to-well contamination. The test card of this invention may comprise from 80 to 140 individual sample wells, for example, in a test card sample test cards of the present invention have a generally rectangular shape sample test card having dimensions of from about 90 to about 95 mm in width, from about 55 to about 60 mm in height and from about 4 to about 5 mm in thickness.

公开(公告)号：EP2321402A2

公开(公告)日：2011-05-18

申请号：EP09788768.1

申请日：2009-05-13

申请人： Biomerieux, Inc

发明人： COLIN, Bruno ,  IAKIMOVA, Yaneli ,  KETSENBURG, Kevin, G. ,  ROBBINS, David, M. ,  BELLET, Stephane

IPC分类号： C12M1/22 ,  C12M1/20 ,  B01L9/00

CPC分类号： C12M23/48 ,  C12M23/10 ,  G01N35/04 ,  G01N2035/042 ,  G01N2035/0425

摘要： A holding structure for holding a plurality of culture plates (12) in a stacked arrangement includes a feature (44) for de-nesting the bottom culture plate from the plate above it. The de-nesting feature is preferably a structure which urges a plate to move laterally relative to the plate above it. The de-nesting of the bottom culture plate from the adjacent culture plate facilitates withdrawal of the bottom culture plate from the base via a robotic plate transfer mechanism. The de-nesting feature can be entirely passive, such as ramps formed in the base of the holding structure.

摘要翻译： 用于保持堆叠布置的多个培养板的保持结构包括用于将底部培养板从其上方的板去嵌套的特征。 解嵌特征优选地是一种促使板相对于其上方的板横向移动的结构。 来自相邻培养板的底部培养板的解嵌有助于通过机器人板转移机构将底部培养板从基底中取出。 解嵌特征可以是完全无源的，例如形成在保持结构的基部中的斜面。