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公开(公告)号：EP2321299A2
公开(公告)日：2011-05-18
申请号：EP09780675.6
申请日：2009-07-15
发明人： ENGELHARDT, Harald , BOEHMELT, Guido , KOFINK, Christiane , KUHN, Daniel , MCCONNELL, Darryl , STADTMUELLER, Heinz
IPC分类号： C07D401/12 , C07D401/04 , C07D401/14 , C07D487/04 , A61K31/435 , A61P35/00
CPC分类号： C07D401/12 , C07D401/04 , C07D401/14 , C07D487/04
摘要： The present invention encompasses compounds of general formula (1) while the groups R
4 to R
7 and the units W, L, Q
a and Q
H are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use as medicaments having the above-mentioned properties.-
公开(公告)号：EP1828123A1
公开(公告)日：2007-09-05
申请号：EP05817469.9
申请日：2005-12-15
发明人： MCCONNELL, Darryl , WEYER-CZERNILOFSKY, Ulrike , IMPAGNATIELLO, Maria , STEURER, Steffen , BRUECKNER, Ralph , KRIST, Bernd , BETZEMEIER, Bodo , HILBERG, Frank , HECKEL, Armin , ROTH, Gerald Juergen , KLEY, Joerg , LEHMANN-LINTZ, Thorsten
IPC分类号： C07D209/34 , C07D405/06 , C07D403/12 , C07D413/04 , C07D401/10 , C07D405/10 , C07D403/04 , C07D401/14 , C07D409/04 , C07D401/04 , A61K31/4523 , A61P35/00
CPC分类号： C07D409/04 , C07D209/34 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/10 , C07D413/04
摘要： The invention relates to indolinone compounds of formula (I), wherein Y and R1 to R8 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation and the use thereof for preparing a pharmaceutical composition.
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3.发明授权THIAZOLYLDIHYDROINDAZOL-DERIVATE ALS PROTEINKINASE- INHIBITOREN 有权THIAZOLYLDIHYDROINDAZOL衍生物作为蛋白激酶抑制剂
公开(公告)号：EP2007774B1
公开(公告)日：2012-07-25
申请号：EP07727565.9
申请日：2007-03-30
发明人： MCCONNELL, Darryl , BETZEMEIER, Bodo , GERSTBERGER, Thomas , IMPAGNATIELLO, Maria , STEURER, Steffen , VAN DER VEEN, Lars , WEYER-CZERNILOFSKY, Ulrike
IPC分类号： C07D513/04 , A61K31/41 , A61P35/00
CPC分类号： C07D513/04
摘要： The present invention comprises compounds of the general formula (1) in which R1 to R6 are each as defined in claim 1 which are suitable for treatment of disorders which are characterized by excessive or abnormal cell proliferation, and their use for producing a medicament with the aforementioned properties.
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4.发明授权TETRA-AZA-HETEROCYCLES AS PHOSPHATIDYLINOSITOL-3-KINASES (PI3-KINASES) INHIBITOR 有权TETRA-AZA-杂环做磷脂酰肌醇3激酶抑制剂
公开(公告)号：EP2350084B1
公开(公告)日：2015-06-24
申请号：EP09784030.0
申请日：2009-10-15
IPC分类号： C07D487/04 , A61K31/415 , A61P35/00
CPC分类号： C07D487/04
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公开(公告)号：EP2007773B1
公开(公告)日：2012-10-24
申请号：EP07727564.2
申请日：2007-03-30
发明人： STEURER, Steffen , BETZEMEIER, Bodo , MCCONNELL, Darryl , GERSTBERGER, Thomas , GRAUERT, Matthias , HOFFMANN, Matthias , IMPAGNATIELLO, Maria , VAN DER VEEN, Lars , WEYER-CZERNILOFSKY, Ulrike
IPC分类号： C07D513/04 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04
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6.发明公开TETRA-AZA-HETEROCYCLES AS PHOSPHATIDYLINOSITOL-3-KINASES (PI3-KINASES) INHIBITOR 有权TETRA-AZA-杂环做磷脂酰肌醇3激酶抑制剂
公开(公告)号：EP2350084A1
公开(公告)日：2011-08-03
申请号：EP09784030.0
申请日：2009-10-15
IPC分类号： C07D487/04 , A61K31/415 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention encompasses compounds of general formula (1) wherein R
1 to R
4 , A, X, m and k are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.-
公开(公告)号：EP1799690B1
公开(公告)日：2008-04-16
申请号：EP05792037.3
申请日：2005-10-05
发明人： BETZEMEIER, Bodo , BRANDL, Trixi , BREITFELDER, Steffen , BRUECKNER, Ralph , GERSTBERGER, Thomas , GMACHL, Michael , GRAUERT, Matthias , HILBERG, Frank , HOENKE, Christoph , HOFFMANN, Matthias , IMPAGNATIELLO, Maria , KESSLER, Dirk , KLEIN, Christian , KRIST, Bernd , MAIER, Udo , MCCONNELL, Darryl , REITHER, Charlotte , SCHEUERER,Stefan , SCHOOP, Andreas , SCHWEIFER, Norbert , SIMON, Oliver , STEEGMAIER, Martin , STEURER, Steffen , WAIZENEGGER, Irene , WEYER-CZERNILOFSKY, Ulrike , ZOEPHEL, Andreas
IPC分类号： C07D513/04 , C07D417/06 , C07D277/82 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04 , C07D277/82 , C07D277/84 , C07D417/06
摘要： The invention relates to the compounds of general formula (1), wherein R1 to R3 are defined as in claim 1, which are suitable for use in the treatment of diseases that are characterized by excessive or abnormal cell proliferation. The invention also relates to the use of said compounds for producing a drug having the aforementioned properties.
摘要翻译： 本发明涉及通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗以过度或异常细胞增殖为特征的疾病。 本发明还涉及所述化合物用于制备具有上述性质的药物的用途。
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公开(公告)号：EP1799690A1
公开(公告)日：2007-06-27
申请号：EP05792037.3
申请日：2005-10-05
发明人： BETZEMEIER, Bodo , BRANDL, Trixi , BREITFELDER, Steffen , BRUECKNER, Ralph , GERSTBERGER, Thomas , GMACHL, Michael , GRAUERT, Matthias , HILBERG, Frank , HOENKE, Christoph , HOFFMANN, Matthias , IMPAGNATIELLO, Maria , KESSLER, Dirk , KLEIN, Christian , KRIST, Bernd , MAIER, Udo , MCCONNELL, Darryl , REITHER, Charlotte , SCHEUERER,Stefan , SCHOOP, Andreas , SCHWEIFER, Norbert , SIMON, Oliver , STEEGMAIER, Martin , STEURER, Steffen , WAIZENEGGER, Irene , WEYER-CZERNILOFSKY, Ulrike , ZOEPHEL, Andreas
IPC分类号： C07D513/04 , C07D417/06 , C07D277/82 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04 , C07D277/82 , C07D277/84 , C07D417/06
摘要： The invention relates to the compounds of general formula (1), wherein R1 to R3 are defined as in claim 1, which are suitable for use in the treatment of diseases that are characterized by excessive or abnormal cell proliferation. The invention also relates to the use of said compounds for producing a drug having the aforementioned properties.
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公开(公告)号：EP2560967B1
公开(公告)日：2017-12-20
申请号：EP11716881.5
申请日：2011-04-20
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , A61K31/517 , A61K31/513 , A61K31/497 , A61K31/501 , A61K31/498 , A61K31/4709 , A61P35/00
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
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公开(公告)号：EP2321299B1
公开(公告)日：2016-02-24
申请号：EP09780675.6
申请日：2009-07-15
发明人： ENGELHARDT, Harald , BOEHMELT, Guido , KOFINK, Christiane , KUHN, Daniel , MCCONNELL, Darryl , STADTMUELLER, Heinz
IPC分类号： C07D401/12 , C07D401/04 , C07D401/14 , C07D487/04 , A61K31/435 , A61P35/00
CPC分类号： C07D401/12 , C07D401/04 , C07D401/14 , C07D487/04
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