公开(公告)号：EP2019825B9

公开(公告)日：2011-01-26

申请号：EP07784947.9

申请日：2007-05-14

申请人： Boehringer Ingelheim International GmbH ,  Boehringer Ingelheim Pharma GmbH & Co. KG

发明人： TSANTRIZOS, Youla, S. ,  BOES, Michael ,  BROCHU, Christian ,  FENWICK, Craig ,  MALENFANT, Eric ,  MASON, Stephen ,  PESANT, Marc

IPC分类号： C07D311/08 ,  A61K31/352 ,  A61K31/47 ,  A61P31/18 ,  C07D215/22 ,  C07D215/14 ,  C07D215/18 ,  C07D311/12 ,  C07D311/14 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D413/12 ,  C07D215/227

CPC分类号： C07D215/22 ,  C07D215/14 ,  C07D215/18 ,  C07D215/227 ,  C07D311/08 ,  C07D311/12 ,  C07D311/14 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D413/12

摘要： The invention relates to compounds of formula (I) their derivatives comprising a detectable label, their compositions and their use in the treatment of human immunodeficiency virus (HIV) infection. In particular, the invention provides novel inhibitors of HIV replication, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection.

公开(公告)号：EP2019825B1

公开(公告)日：2010-09-01

申请号：EP07784947.9

申请日：2007-05-14

申请人： Boehringer Ingelheim International GmbH ,  Boehringer Ingelheim Pharma GmbH & Co. KG

发明人： TSANTRIZOS, Youla, S. ,  BOES, Michael ,  BROCHU, Christian ,  FENWICK, Craig ,  MALENFANT, Eric ,  MASON, Stephen ,  PESANT, Marc

IPC分类号： C07D311/08 ,  A61K31/352 ,  A61K31/47 ,  A61P31/18 ,  C07D215/22 ,  C07D215/14 ,  C07D215/18 ,  C07D311/12 ,  C07D311/14 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D413/12 ,  C07D215/227

CPC分类号： C07D215/22 ,  C07D215/14 ,  C07D215/18 ,  C07D215/227 ,  C07D311/08 ,  C07D311/12 ,  C07D311/14 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D413/12

摘要： The invention relates to compounds of formula (I) their derivatives comprising a detectable label, their compositions and their use in the treatment of human immunodeficiency virus (HIV) infection. In particular, the invention provides novel inhibitors of HIV replication, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection.

公开(公告)号：EP2019825A1

公开(公告)日：2009-02-04

申请号：EP07784947.9

申请日：2007-05-14

申请人： Boehringer Ingelheim International GmbH ,  Boehringer Ingelheim Pharma GmbH & Co. KG

发明人： TSANTRIZOS, Youla, S. ,  BOES, Michael ,  BROCHU, Christian ,  FENWICK, Craig ,  MALENFANT, Eric ,  MASON, Stephen ,  PESANT, Marc

IPC分类号： C07D311/08 ,  A61K31/352 ,  A61K31/47 ,  A61P31/18 ,  C07D215/22

CPC分类号： C07D215/22 ,  C07D215/14 ,  C07D215/18 ,  C07D215/227 ,  C07D311/08 ,  C07D311/12 ,  C07D311/14 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D413/12

摘要： The invention relates to compounds of formula (I) their derivatives comprising a detectable label, their compositions and their use in the treatment of human immunodeficiency virus (HIV) infection. In particular, the invention provides novel inhibitors of HIV replication, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection.

公开(公告)号：EP2748167B1

公开(公告)日：2017-03-01

申请号：EP12825396.0

申请日：2012-08-22

申请人： Boehringer Ingelheim International GmbH

发明人： BROCHU, Christian ,  GRAND-MAÎTRE, Chantal ,  JOLY, Marc-André ,  KUHN, Cyrille ,  BERTRAND-LAPERLE, Mégan ,  PESANT, Marc

IPC分类号： C07D487/04 ,  A61K31/395 ,  A61K31/4162 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/497 ,  A61P31/14 ,  C07D513/04

CPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/497 ,  C07D513/04

公开(公告)号：EP2748167A1

公开(公告)日：2014-07-02

申请号：EP12825396.0

申请日：2012-08-22

申请人： Boehringer Ingelheim International GmbH

发明人： BROCHU, Christian ,  GRAND-MAÎTRE, Chantal ,  JOLY, Marc-André ,  KUHN, Cyrille ,  BERTRAND-LAPERLE, Mégan ,  PESANT, Marc

IPC分类号： C07D487/04 ,  A61K31/395 ,  A61K31/4162 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/497 ,  A61P31/14

CPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/497 ,  C07D513/04

摘要： Compounds of Formula (I) wherein n, X
1 , X
2 , R
1 , R
2 , Y
1 , Y
2 and R
A are defined herein, are useful for the treatment of hepatitis C viral infection.

摘要翻译： 其中n，X 1，X 2，R 1，R 2，Y 1，Y 2和R A如本文所定义的式（I）化合物可用于治疗丙型肝炎病毒感染。

公开(公告)号：EP2477976A1

公开(公告)日：2012-07-25

申请号：EP10816523.4

申请日：2010-09-16

申请人： Boehringer Ingelheim International GmbH

发明人： STAMMERS, Timothy ,  BARBEAU, Xavier ,  BEAULIEU, Pierre ,  BERTRAND-LAPERLE, Megan ,  BROCHU, Christian ,  EDWARDS, Paul, J. ,  FORGIONE, Pasquale ,  GODBOUT, Cédrickx ,  HUCKE, Oliver ,  JOLY, Marc-André ,  LANDRY, Serge ,  LEPAGE, Olivier ,  NAUD, Julie ,  PESANT, Marc ,  POIRIER, Martin ,  POIRIER, Maude ,  THAVONEKHAM, Bounkham

IPC分类号： C07D401/12 ,  A61K31/517 ,  A61K31/14 ,  C07C211/29 ,  C07C233/13 ,  C07C237/44 ,  C07C251/48 ,  C07C255/58 ,  C07D213/74 ,  C07D239/42 ,  C07D239/88 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  C07F5/02

CPC分类号： C07D401/12 ,  A61K31/14 ,  A61K31/517 ,  C07C211/29 ,  C07C233/11 ,  C07C237/44 ,  C07C251/48 ,  C07C255/58 ,  C07C255/59 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  C07F5/025

摘要： Compounds of formula I: (I) wherein X, R
2 , R
3 , R
5 and R
6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.

公开(公告)号：EP2748160A1

公开(公告)日：2014-07-02

申请号：EP12825872.0

申请日：2012-08-22

申请人： Boehringer Ingelheim International GmbH

发明人： BROCHU, Christian ,  GRAND-MAÎTRE, Chantal ,  FADER, Lee ,  KUHN, Cyrille ,  BERTRAND-LAPERLE, Mégan ,  PESANT, Marc

IPC分类号： C07D403/14 ,  A61K31/395 ,  A61K31/403 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/519 ,  A61P31/14 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

CPC分类号： C07D471/04 ,  A61K31/403 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/433 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/497 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D491/107

摘要： A compound of formula (I) useful for the treatment or prevention of hepatitis C viral infection, (Formula (I)) wherein: X
1 and X
2 are each independently CR
B or N; R
B is H, (C
1-6 )alkyl, (C
1-6 )haloalkyl, halo. -O-(C
1-6 )alkyl, NH
2 , NH(C
1-6 )alkyl or N((C
1-6 )alkyl)
2 ; R
1 and R
2 are each independently (C
1-6 )alkyl optionally mono- or di-substituted with -O-(C
1-6 )alkyl, NH
2 , NH(C
1-6 )alkyl or N((C
1-6 )alkyl)
2 ; or R
1 and R
2 , together with the carbon to which they are attached, are linked to form a (C
3-7 )cycloalkyl group or a 3- to 7-membered heterocyclyl, said cycloalkyl and heterocyclyl being optionally mono- or di-substituted with -(C
1-6 )alkyl; R
A is -C(=O)N(R
3 )(R
4 ), -C(=O)O(R
4 ), heterocyclyl or heteroaryl, wherein each said heterocyclyl and heteroaryl is optionally substituted 1 to 3 times with R
41 ; R
5 and R
6 are each independently H or (C
1-6 )alkyl optionally mono- or di-substituted with -O-(C
1-6 )alkyl, NH
2 , NH(C
1-6 )alkyl or N((C
1-6 )alkyl)
2 ; or R
5 and R
6 , together with the carbon to which they are attached, are linked to form a (C
3-7 )cycloalkyl group or a 3- to 7-membered heterocyclyl, said cycloalkyl and heterocyclyl being optionally mono- or di-substituted with -(C
1-6 )alkyl; and n is 0, 1 or 2.