公开(公告)号：EP2320954B1

公开(公告)日：2019-09-04

申请号：EP09800042.5

申请日：2009-07-21

申请人： Bracco Imaging S.p.A.

发明人： ROSSELLO, Armando ,  NUTI, Elisa ,  AVRAMOVA, Stanislava Ivanova ,  UGGERI, Fulvio ,  MAIOCCHI, Alessandro

IPC分类号： A61K49/00 ,  A61K49/10 ,  A61K49/22 ,  A61K51/04

公开(公告)号：EP2059500A2

公开(公告)日：2009-05-20

申请号：EP07787889.0

申请日：2007-07-25

申请人： Bracco Imaging S.p.A

发明人： ROSSELLO, Armando ,  NUTI, Elisa ,  ORLANDINI, Elisabetta ,  BALSAMO, Aldo ,  PANELLI, Laura

IPC分类号： C07C317/14 ,  C07C321/24 ,  A61P21/00 ,  A61P35/00 ,  A61K31/10

CPC分类号： C07C317/44 ,  C07C317/14 ,  C07C317/22 ,  C07C323/62 ,  C07D207/46 ,  C07D209/48 ,  C07D211/76 ,  C07D239/60 ,  C07F9/3882

摘要： There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R1, R2, n and ZBG have the meanings reported in the description useful, in therapy, as inhibitors of zinc metalloproteinases.

公开(公告)号：EP2320954A1

公开(公告)日：2011-05-18

申请号：EP09800042.5

申请日：2009-07-21

申请人： Bracco Imaging S.p.A

发明人： ROSSELLO, Armando ,  NUTI, Elisa ,  AVRAMOVA, Stanislava Ivanova ,  UGGERI, Fulvio ,  MAIOCCHI, Alessandro

IPC分类号： A61K49/00 ,  A61K49/10 ,  A61K49/22 ,  A61K51/04 ,  A61P43/00 ,  C07C311/48 ,  C07D295/08 ,  C07D295/088

CPC分类号： A61K49/0017 ,  A61K49/085 ,  A61K49/10 ,  A61K49/101 ,  A61K49/103 ,  A61K49/105 ,  A61K49/106 ,  A61K49/221 ,  A61K51/0497

摘要： The invention relates to aryl-sulphonamido compounds endowed with affinity against metallo proteases MMP, having formula (I) below wherein R, R 1 , R 2 , R 3 , G and n have the meanings reported in the specification, properly labelled with diagnostic imaging moieties or even radiotherapeutic moieties. The invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as diagnostic imaging agents or radiotherapeutic agents.

公开(公告)号：EP2121590A2

公开(公告)日：2009-11-25

申请号：EP08717820.8

申请日：2008-03-14

申请人： Bracco Imaging S.p.A

发明人： ROSSELLO, Armando ,  NUTI, Elisa ,  ORLANDINI, Elisabetta ,  BALSAMO, Aldo ,  TUCCINARDI, Tiziano

IPC分类号： C07C311/48 ,  C07D295/08 ,  A61K31/18 ,  A61P35/00

CPC分类号： C07C311/48 ,  C07D295/08 ,  C07D295/088

摘要： The invention relates to aryl-sulphonamido compounds endowed with inhibitory activity against metallo proteases MMP, having Formula (I) below wherein R, R 1, R 2, R 3, R 4, R 5, n and m have the meanings reported in the specification; the invention also refers to the process for their preparation, to pharmaceutical compositions comprising them andto their use as therapeutic agents, particularly in the treatment ofdegenerative disorders.

公开(公告)号：EP2323998A1

公开(公告)日：2011-05-25

申请号：EP09800043.3

申请日：2009-07-21

申请人： Bracco Imaging S.p.A

发明人： ROSSELLO, Armando ,  NUTI, Elisa ,  TUCCINARDI, Tiziano ,  ORLANDINI, Elisabetta

IPC分类号： C07D295/205 ,  C07C311/00 ,  A61K31/496 ,  A61P25/00

CPC分类号： C07D295/205

摘要： The invention relates to dimeric aryl-sulphonamido compounds endowed with inhibitory activity against metalloproteases MMP, having formula (I) below (M)-L-(M') (I), wherein M and M', the same or different from each other, represent the residues of the metalloproteases inhibitors of formula (II), wherein R, R
1 , R
2, R
3 , G and n have the meanings reported in the specification; the invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of degenerative disorders.