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公开(公告)号：EP2132203A1
公开(公告)日：2009-12-16
申请号：EP08745365.0
申请日：2008-04-09
发明人： MARINIER, Anne , DODIER, Marco , ROY, Stephan , ZIMMERMANN, Kurt , SANG, Xiaopeng , WITTMAN, Mark D. , LANGLEY, David R. , RAJAMANI, Ramkumar
IPC分类号： C07D417/14 , A61K31/4427
CPC分类号： C07D417/14
摘要： The invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula I thiazolyl compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's disease.
摘要翻译： 本发明提供了式（I）的化合物及其药学上可接受的盐。 式I噻唑基化合物抑制酪氨酸激酶活性，从而使它们可用作抗癌剂并用于治疗阿尔茨海默氏病。
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公开(公告)号：EP2099794A2
公开(公告)日：2009-09-16
申请号：EP07869520.2
申请日：2007-12-19
发明人： MARINIER, Anne , QUESNELLE, Claude , DODIER, Marco , ROY, Stephan , GILL, Patrice , WITTMAN, Mark D. , LANGLEY, David R.
IPC分类号： C07D417/14
CPC分类号： C07D417/14 , C07D495/04
摘要： The invention provides compounds of formula I [INSERT CHEMICAL STRUCTURE HERE] (I) and pharmaceutically acceptable salts thereof. The formula I thiazolyl compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
摘要翻译： 本发明提供了式I化合物[插入其中的化学结构]（I）及其药学上可接受的盐。 式I噻唑基化合物抑制酪氨酸激酶活性，从而使它们可用作抗癌剂并用于治疗阿尔茨海默氏病。
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3.发明授权THIOPHENE-BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME 有权三环类化合物对THIOPHENGRUNDLAGE和药物组合物含
公开(公告)号：EP1490371B1
公开(公告)日：2007-08-15
申请号：EP03718092.4
申请日：2003-03-27
发明人： BELEMA, Makonen , BUNKER, Amy , NGUYEN, Van , BEAULIEU, Francis , OUELLET, Carl , MARINIER, Anne , ROY, Stephan , YANG, Xuejie , QIU, Yuping , ZHANG, Yunhui , MARTEL, Alain , ZUSI, Christopher
IPC分类号： C07D495/14 , A61K31/4985 , A61P9/00
CPC分类号： C07D495/14
摘要： Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, are useful as anti-inflammatory agents, in which R1, R2, and R3 are hydrogen, halogen, alkyl, or perfluoroalkyl; R4 is an optionally substituted alkyl or cycloalkyl group; X is a linker; A is an aryl, heteroaryl, heterocycle, cycloalkyl, or is absent; and R7 is a substituent on A as defined in the specification.
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4.发明公开THIOPENE-BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME 有权三环类化合物对THIOPHENGRUNDLAGE和药物组合物含
公开(公告)号：EP1490371A1
公开(公告)日：2004-12-29
申请号：EP03718092.4
申请日：2003-03-27
发明人： BELEMA, Makonen , BUNKER, Amy , NGUYEN, Van , BEAULIEU, Francis , OUELLET, Carl , MARINIER, Anne , ROY, Stephan , YANG, Xuejie , QIU, Yuping , ZHANG, Yunhui , MARTEL, Alain , ZUSI, Christopher
IPC分类号： C07D487/04 , C07D487/14 , C07D487/20
CPC分类号： C07D495/14
摘要： Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, are useful as anti-inflammatory agents, in which R1, R2, and R3 are hydrogen, halogen, alkyl, or perfluoroalkyl; R4 is an optionally substituted alkyl or cycloalkyl group; X is a linker; A is an aryl, heteroaryl, heterocycle, cycloalkyl, or is absent; and R7 is a substituent on A as defined in the specification.
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公开(公告)号：EP2099794B1
公开(公告)日：2013-05-15
申请号：EP07869520.2
申请日：2007-12-19
发明人： MARINIER, Anne , QUESNELLE, Claude , DODIER, Marco , ROY, Stephan , GILL, Patrice , WITTMAN, Mark D. , LANGLEY, David R.
IPC分类号： C07D417/14
CPC分类号： C07D417/14 , C07D495/04
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公开(公告)号：EP1651611A2
公开(公告)日：2006-05-03
申请号：EP04786135.6
申请日：2004-07-28
IPC分类号： C07D231/18 , C07D231/28 , C07D235/04 , C07D237/16 , C07D239/46 , A61K31/501 , A61K31/506 , A61K31/4155 , A61P35/00
CPC分类号： C07D403/04
摘要： Benzimidazole derivatives having the general formula (I) are provided. These compounds are useful as tyrosine kinase inhibitors, especially for the treatment of cancer.
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公开(公告)号：EP1545543A2
公开(公告)日：2005-06-29
申请号：EP03774510.6
申请日：2003-10-01
发明人： WITTMAN, Mark, D. , BALASUBRAMANIAN, Neelakantan , VELAPARTHI, Upender , ZIMMERMANN, Kurt , SAULNIER, Mark, G. , LIU, Peiying , SANG, Xiaopeng , FRENNESSON, David, B. , STOFFAN, Karen, M. , TARRANT, James, G. , MARINIER, Anne , ROY, Stephan
IPC分类号： A61K31/5355 , C07D413/14
CPC分类号： C07D417/14 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents.
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