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公开(公告)号：EP3356330B1
公开(公告)日：2019-11-20
申请号：EP16781938.2
申请日：2016-09-29
Applicant: Bristol-Myers Squibb Company
Inventor： BRONSON, Joanne J. , CHEN, Ling , DITTA, Jonathan L. , DZIERBA, Carolyn Diane , JALAGAM, Prasada Rao , LUO, Guanglin , MACOR, John E. , MAISHAL, Tarun Kumar , NARA, Susheel Jethanand , RAJAMANI, Ramkumar , SISTLA, Ramesh Kumar , THANGAVEL, Soodamani
IPC: C07D231/12 , C07D213/74 , C07D213/75 , C07D401/04 , C07D401/12 , C07D405/12 , C07D239/36 , C07D239/42 , C07D409/12 , C07D239/72 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04
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2.发明授权5H-CHROMENO[3,4-C]PYRIDINES AS INHIBITORS OF ADAPTOR ASSOCIATED KINASE 1 (AAK1) 有权5H-氯 - [3,4-C-]吡啶ALS抑制剂ADAPTERASSOZIIERTEN激酶1（AAK1）
公开(公告)号：EP2958924B1
公开(公告)日：2016-12-28
申请号：EP14706201.2
申请日：2014-02-06
Applicant: Bristol-Myers Squibb Company
Inventor： VRUDHULA, Vivekananda M. , DZIERBA, Carolyn Diane , BRONSON, Joanne J. , MACOR, John E. , NARA, Susheel Jethanand , RAJAMANI, Ramkumar , KARATHOLUVHU, Maheswaran Sivasamban
IPC: C07D491/052 , A61K31/4375 , A61P25/28 , A61P25/16 , A61P25/18 , A61P25/02
CPC classification number: C07D491/052
Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
Abstract translation: 本公开一般涉及可以抑制AAK1（衔接子相关激酶1），包含这些化合物的组合物和抑制AAK1的方法的化合物。
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3.发明公开TRIAZOLOPYRIDINE ETHER DERIVATIVES AND THEIR USE IN NEUROLOGICAL AND PYSCHIATRIC DISORDERS 审中-公开TRIAZOLOPYRIDINETHERDERIVATE及它们在神经和精神疾病
公开(公告)号：EP3046922A1
公开(公告)日：2016-07-27
申请号：EP14784388.2
申请日：2014-09-18
Applicant: Bristol-Myers Squibb Company
Inventor： MARCIN, Lawrence R. , HIGGINS, Mendi A. , BRONSON, Joanne J. , ZUSI, F. Christopher , MACOR, John E. , DING, Min
IPC: C07D471/04 , A61K31/437 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22
CPC classification number: C07D471/04 , C07B59/002 , C07B2200/05
Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds modulate the mGluR2 receptor and may be useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：EP3099673B1
公开(公告)日：2018-09-26
申请号：EP15704881.0
申请日：2015-01-23
Applicant: Bristol-Myers Squibb Company
Inventor： HARTZ, Richard A. , AHUJA, Vijay T. , MACOR, John E. , BRONSON, Joanne J. , DASGUPTA, Bireshwar , DZIERBA, Carolyn Diane , NARA, Susheel Jethanand , KARATHOLUVHU, Maheswaran Sivasamban
IPC: C07D401/14 , C07D215/12 , C07D215/18 , C07D401/04 , C07D413/04 , C07D471/04 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28
CPC classification number: C07D401/04 , C07D215/12 , C07D215/18 , C07D401/14 , C07D413/04 , C07D471/04
Abstract: The present disclosure is generally directed to compounds of formula (I) which can inhibit AAKI (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAKI.
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公开(公告)号：EP3356330A1
公开(公告)日：2018-08-08
申请号：EP16781938.2
申请日：2016-09-29
Applicant: Bristol-Myers Squibb Company
Inventor： BRONSON, Joanne J. , CHEN, Ling , DITTA, Jonathan L. , DZIERBA, Carolyn Diane , JALAGAM, Prasada Rao , LUO, Guanglin , MACOR, John E. , MAISHAL, Tarun Kumar , NARA, Susheel Jethanand , RAJAMANI, Ramkumar , SISTLA, Ramesh Kumar , THANGAVEL, Soodamani
IPC: C07D231/12 , C07D213/74 , C07D213/75 , C07D401/04 , C07D401/12 , C07D405/12 , C07D239/36 , C07D239/42 , C07D409/12 , C07D239/72 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAKl (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.
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Patent Agency Ranking
公开(公告)号：EP2822952A1
公开(公告)日：2015-01-14
申请号：EP13710203.4
申请日：2013-02-28
Applicant: Bristol-Myers Squibb Company
Inventor： VRUDHULA, Vivekananda M. , PAN, Senliang , RAJAMANI, Ramkumar , MACOR, John E. , BRONSON, Joanne J. , DZIERBA, Carolyn Diane , NARA, Susheel Jethanand , KARATHOLUVHU, Maheswaran Sivasamban
IPC: C07D491/04 , A61K31/444 , A61P25/00
CPC classification number: C12N9/99 , C07D491/04 , C07D491/052 , C07D491/20
Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
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7.发明公开
公开(公告)号：EP2069328A2
公开(公告)日：2009-06-17
申请号：EP07813277.6
申请日：2007-07-24
Applicant: Bristol-Myers Squibb Company
Inventor： PARKER, Michael F. , BRONSON, Joanne J. , SILVA, Mark V. , GILLMAN, Kevin W.
IPC: C07D401/12 , C07D401/14 , C07D413/14 , A61K31/4465 , A61K31/4545 , A61P25/00
CPC classification number: C07D401/12 , C07D401/14 , C07D413/14
Abstract: The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders.
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公开(公告)号：EP3200797A1
公开(公告)日：2017-08-09
申请号：EP15778153.5
申请日：2015-09-25
Applicant: Bristol-Myers Squibb Company
Inventor： HARTZ, Richard A. , AHUJA, Vijay T. , MACOR, John E. , BRONSON, Joanne J. , DASGUPTA, Bireshwar , DZIERBA, Carolyn Diane , NARA, Susheel Jethanand , KARATHOLUVHU, Maheswaran Sivasamban
IPC: A61K31/517 , A61P25/28 , A61P25/16 , A61P25/00
CPC classification number: A61K31/517
Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
Abstract translation: 本发明通常涉及可抑制AAK1（适配体相关激酶1）的化合物，包含此类化合物的组合物，以及抑制AAK1的方法。
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公开(公告)号：EP2486011B1
公开(公告)日：2017-04-26
申请号：EP10763963.5
申请日：2010-10-06
Inventor： DZIERBA, Carolyn, Diane , HARTZ, Richard, A. , BI, Yingzhi , AHUJA, Vijay T. , BRONSON, Joanne J. , CARSON, Kenneth , CIANCHETTA, Giovanni , GREEN, Michael , KIMBALL, David , KIMURA, S. Roy , KWON, Soojin , MACOR, John E. , ZHANG, Yulian , ZIPP, Greg
IPC: C07D207/40 , C07D213/40 , C07D231/12 , C07D277/32 , C07C233/05 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/4406 , A61P3/00 , A61P25/00
CPC classification number: C07D207/40 , C07B2200/07 , C07C233/22 , C07C233/40 , C07C237/06 , C07C2601/02 , C07C2601/08 , C07D213/40 , C07D231/12 , C07D277/32
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公开(公告)号：EP2880032B1
公开(公告)日：2016-10-05
申请号：EP13744927.8
申请日：2013-07-24
Applicant: Bristol-Myers Squibb Company
Inventor： VRUDHULA, Vivekananda M. , PAN, Senliang , RAJAMANI, Ramkumar , NARA, Susheel Jethanand , KARATHOLUVHU, Maheswaran Sivasamban , MAISHAL, Tarun Kumar , DITTA, Jonathan L. , DZIERBA, Carolyn Diane , BRONSON, Joanne J. , MACOR, John E.
IPC: C07D471/04 , A61K31/4375 , A61P25/02 , A61P25/16 , A61P25/28
CPC classification number: C07D471/04
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