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1.发明授权PYRROLOPYRIDAZINE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 有权吡咯并哒化合物及其使用增殖性疾病的治疗方法
公开(公告)号：EP1578351B1
公开(公告)日：2010-12-08
申请号：EP03719500.5
申请日：2003-03-26
IPC分类号： C07D487/04 , A61K31/5025 , A61P29/00 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06 , Y02A50/411 , A61K2300/00
摘要： Disclosed are pyrrolopyridazine compounds of the formula, wherein the substituents are defined herein, methods of preparing such compounds, and their use for the treatment of proliferative, inflammatory, and other disorders.
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公开(公告)号：EP1928879A2
公开(公告)日：2008-06-11
申请号：EP06825074.5
申请日：2006-09-22
发明人： VACCARO, Wayne , CHEN, Zhong , DODD, Dharmpal, S. , HUYNH, Tram, N. , LIN, James , LIU, Chunjian , MUSSARI, Christopher, P. , TOKARSKI, John, S. , TORTOLANI, David, R. , WROBLESKI, Stephen, T.
IPC分类号： C07D487/04 , A61K31/437 , A61P29/00
CPC分类号： C07D487/04
摘要： Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, and hydrates, thereof, (I) are useful as kinase modulators, including MK2 modulation, wherein one of E and F is a nitrogen atom and the other of E and F is a carbon atom, and Z is N or CR3, and R1, R2, R3, X and Y are as defined herein.
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公开(公告)号：EP1761268A2
公开(公告)日：2007-03-14
申请号：EP05791275.0
申请日：2005-06-28
发明人： BORZILLERI, Robert, M. , CHEN, Zhong , HUNT, John, T. , HUYNH, Tram, N. , POSS, Michael, A. , SCHROEDER, Gretchen, M. , VACCARO, Wayne , WONG, Tai,W. , CHEN, Xiao Tao , KIM, Kyoung, S.
IPC分类号： A61K31/53 , C07D487/04 , C07D253/10 , A61P19/02 , A61P35/00
CPC分类号： C07D471/04 , C07D473/00 , C07D473/30 , C07D487/04 , C07D495/04
摘要： In general, the instant invention comprises compounds of Formulas I and II including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.
摘要翻译： 通常，本发明包括式I和II化合物，包括其药学上可接受的盐。 本发明的化合物可用作蛋白激酶抑制剂，因此可用于治疗癌症和其他蛋白激酶介导的疾病。
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公开(公告)号：EP1768983A2
公开(公告)日：2007-04-04
申请号：EP05764291.0
申请日：2005-06-28
发明人： BORZILLERI, Robert M. , CHEN, Zhong , HUYNH, Tram N. , VACCARO, Wayne , CHEN, Xiao Tao , KIM, Kyoung S. , CAI, Zhen-Wei
IPC分类号： C07D487/04
CPC分类号： C07D471/04 , C07D473/00 , C07D473/30 , C07D487/04 , C07D495/04
摘要： In general, the instant invention comprises compounds of Formulas (I) and (II) including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.
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公开(公告)号：EP1928879B1
公开(公告)日：2013-02-13
申请号：EP06825074.5
申请日：2006-09-22
发明人： VACCARO, Wayne , CHEN, Zhong , DODD, Dharmpal, S. , HUYNH, Tram, N. , LIN, James , LIU, Chunjian , MUSSARI, Christopher, P. , TOKARSKI, John, S. , TORTOLANI, David, R. , WROBLESKI, Stephen, T.
IPC分类号： C07D487/04 , A61K31/437 , A61P29/00
CPC分类号： C07D487/04
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6.发明公开PYRROLOPYRIDAZINE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 有权吡咯并哒化合物及其使用增殖性疾病的治疗方法
公开(公告)号：EP1578351A2
公开(公告)日：2005-09-28
申请号：EP03719500.5
申请日：2003-03-26
IPC分类号： A61K6/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06 , Y02A50/411 , A61K2300/00
摘要： Disclosed are pyrrolopyridazine compounds of the formula, wherein the substituents are defined herein, methods of preparing such compounds, and their use for the treatment of proliferative, inflammatory, and other disorders.
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