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公开(公告)号：EP1928879A2
公开(公告)日：2008-06-11
申请号：EP06825074.5
申请日：2006-09-22
发明人： VACCARO, Wayne , CHEN, Zhong , DODD, Dharmpal, S. , HUYNH, Tram, N. , LIN, James , LIU, Chunjian , MUSSARI, Christopher, P. , TOKARSKI, John, S. , TORTOLANI, David, R. , WROBLESKI, Stephen, T.
IPC分类号： C07D487/04 , A61K31/437 , A61P29/00
CPC分类号： C07D487/04
摘要： Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, and hydrates, thereof, (I) are useful as kinase modulators, including MK2 modulation, wherein one of E and F is a nitrogen atom and the other of E and F is a carbon atom, and Z is N or CR3, and R1, R2, R3, X and Y are as defined herein.
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公开(公告)号：EP1699797A1
公开(公告)日：2006-09-13
申请号：EP04815269.8
申请日：2004-12-23
发明人： FINK, Brian, E. , GAVAI, Ashvinikumar, V. , VITE, Gregory, D. , CHEN, Ping , MASTALERZ, Harold , NORRIS, Derek, J. , TOKARSKI, John, S. , ZHAO, Yufen , HAN, Wen-Ching
IPC分类号： C07D487/04 , C07D519/00 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides compounds of formula (I); and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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公开(公告)号：EP1699797B1
公开(公告)日：2009-09-23
申请号：EP04815269.8
申请日：2004-12-23
发明人： FINK, Brian, E. , GAVAI, Ashvinikumar, V. , VITE, Gregory, D. , CHEN, Ping , MASTALERZ, Harold , NORRIS, Derek, J. , TOKARSKI, John, S. , ZHAO, Yufen , HAN, Wen-Ching
IPC分类号： C07D487/04 , C07D519/00 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides compounds of formula (I); and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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公开(公告)号：EP1513818A2
公开(公告)日：2005-03-16
申请号：EP03761106.8
申请日：2003-06-18
发明人： BORZILLERI, Robert, M. , TOKARSKI, John, S. , BHIDE, Rajeev, S. , ZHENG, Peter , QIAN, Ligang , CAI, Zhen-Wei
IPC分类号： C07D233/70 , C07D233/84 , C07C233/88 , C07D263/38 , C07D263/46 , C07D263/48 , C07D277/34 , C07D277/36 , C07D277/38 , A61K31/42 , A61P35/00
CPC分类号： C07D277/42 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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5.发明公开FUSED HETEROTRICYCLIC COMPOUNDS AS INHIBITORS OF 17B-HYDROXYSTEROID DEHYDROGENASE 3 有权电熔化合物作为杂三环17B羟类固醇脱氢酶3抑制剂的
公开(公告)号：EP1725565A2
公开(公告)日：2006-11-29
申请号：EP05732158.0
申请日：2005-02-28
发明人： GAVAI, Ashvinikumar, V. , NORRIS, Derek, J. , HAN, Wen-Ching , VITE, Gregory, D. , FINK, Brian, E. , TOKARSKI, John, S.
IPC分类号： C07D487/14
CPC分类号： C07D471/04 , C07D487/04
摘要： Fused heterotricyclic compounds, methods of using such compounds in the treatment of hormone sensitive diseases such as prostate cancer, and pharmaceutical compositions containing such compounds.
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公开(公告)号：EP1937682B1
公开(公告)日：2015-08-12
申请号：EP06804275.3
申请日：2006-09-29
发明人： BORZILLERI, Robert, M. , CHEN, Xiao-Tao , WILLIAMS, David, K. , TOKARSKI, John, S. , KALTENBACH, Robert, F.
IPC分类号： C07D471/04 , C07D401/12 , C07D213/82 , A61K31/407 , A61K31/445 , A61K31/45 , A61P35/00
CPC分类号： C07D401/12 , C07D213/82 , C07D471/04
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7.发明授权FUSED HETEROTRICYCLIC COMPOUNDS AS INHIBITORS OF 17B-HYDROXYSTEROID DEHYDROGENASE 3 有权电熔化合物作为杂三环17B羟类固醇脱氢酶3抑制剂的
公开(公告)号：EP1725565B1
公开(公告)日：2013-07-03
申请号：EP05732158.0
申请日：2005-02-28
发明人： GAVAI, Ashvinikumar, V. , NORRIS, Derek, J. , HAN, Wen-Ching , VITE, Gregory, D. , FINK, Brian, E. , TOKARSKI, John, S.
IPC分类号： A61P35/00 , A61K31/535 , A61K31/505 , A61K31/44 , C07D267/00 , C07D281/00 , C07D487/00
CPC分类号： C07D471/04 , C07D487/04
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8.发明公开FUSED TRICYCLIC COMPOUNDS AS INHIBITORS OF 17BETA-HYDROXYSTEROID DEHYDROGERNASE 3 审中-公开稠合三环化合物作为17-β-羟类固醇脱氢酶3抑制剂
公开(公告)号：EP1720613A2
公开(公告)日：2006-11-15
申请号：EP05724147.3
申请日：2005-02-28
发明人： FINK, Brian, E. , GAVAI, Ashvinikumar, V. , VITE, Gregory, D. , HAN, Wen-Ching , MISRA, Raj, N. , XIAO, Hai-Yun , NORRIS, Derek, J. , TOKARSKI, John, S.
IPC分类号： A61P35/00 , C07D487/00 , C07D491/00 , C07D513/00 , A61K31/33 , A61K31/335 , A61K31/34 , A61K31/36 , A61K31/41 , A61K31/42 , A61K31/445
CPC分类号： C07D225/02 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D491/04
摘要： Fused tricyclic compounds, methods of using such compounds in the treatment of hormone sensitive diseases such as prostate cancer, and pharmaceutical compositions containing such compounds.
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公开(公告)号：EP1928879B1
公开(公告)日：2013-02-13
申请号：EP06825074.5
申请日：2006-09-22
发明人： VACCARO, Wayne , CHEN, Zhong , DODD, Dharmpal, S. , HUYNH, Tram, N. , LIN, James , LIU, Chunjian , MUSSARI, Christopher, P. , TOKARSKI, John, S. , TORTOLANI, David, R. , WROBLESKI, Stephen, T.
IPC分类号： C07D487/04 , A61K31/437 , A61P29/00
CPC分类号： C07D487/04
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公开(公告)号：EP1513818B1
公开(公告)日：2010-01-20
申请号：EP03761106.8
申请日：2003-06-18
发明人： BORZILLERI, Robert, M. , TOKARSKI, John, S. , BHIDE, Rajeev, S. , ZHENG, Peter , QIAN, Ligang , CAI, Zhen-Wei
IPC分类号： C07D233/70 , C07D233/84 , C07C233/88 , C07D263/38 , C07D263/46 , C07D263/48 , C07D277/34 , C07D277/36 , C07D277/38 , A61K31/42 , A61P35/00 , C07D277/42 , C07D417/12 , C07D417/14
CPC分类号： C07D277/42 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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