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1.发明公开QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 有权CHINUKLIDINE衍生物如α-7尼古丁乙酰胆碱受体配体
公开(公告)号：EP2493892A1
公开(公告)日：2012-09-05
申请号：EP09744572.0
申请日：2009-10-29
发明人： COOK II, James H. , MCDONALD, Ivar, M. , KING, Dalton , OLSON, Richard, E. , WANG, Nenghui , IWUAGWU, Christiana, I. , ZUSI, F.,Christopher , MACOR, John, E.
IPC分类号： C07D498/20 , A61K31/439 , A61P25/28
CPC分类号： C07D498/20
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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2.发明授权AZABICYCLO[2.2.1]HEPTANE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 有权氮杂双环[2.2.1]庚烷化合物AS ALPHA-7烟碱乙酰胆碱REZPETORLIGANDEN
公开(公告)号：EP2493893B1
公开(公告)日：2014-01-15
申请号：EP10774092.0
申请日：2010-10-25
发明人： MCDONALD, Ivar M. , MATE, Robert A. , COOK II, James H. , KING, Dalton , OLSON, Richard E. , WANG, Nenghui , IWUAGWU, Christiana I. , ZUSI, F. Christopher , HILL, Matthew D. , FANG, Haiquan , MACOR, John E.
IPC分类号： C07D498/20 , C07D519/00 , A61K31/439 , A61P25/18 , A61P25/28
CPC分类号： C07D498/20 , C07D519/00
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3.发明公开QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 审中-公开喹啉化合物作为α-7烟碱乙酰胆碱受体配体
公开(公告)号：EP3215512A1
公开(公告)日：2017-09-13
申请号：EP15791229.6
申请日：2015-11-03
IPC分类号： C07D498/10 , A61K31/439 , A61P25/00
CPC分类号： C07D498/22 , A61K31/439 , C07D498/10
摘要： There are disclosed a series of quinuclidines having the Formula (I). which bind to the nicotinic α7 receptor and may be useful for the treatment of disorders of the central nervous system.
摘要翻译： 公开了一系列具有式（I）的奎宁环。 其与烟碱α7受体结合并可用于治疗中枢神经系统疾病。
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4.发明授权AZABICYCLIC COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 有权AYABICYCLISCHE化合物如α-7烟碱乙酰胆碱REZPETORLIGANDEN
公开(公告)号：EP2493894B1
公开(公告)日：2014-01-29
申请号：EP10776869.9
申请日：2010-10-26
发明人： MCDONALD, Ivar M. , MATE, Robert A. , COOK II, James H. , KING, Dalton , OLSON, Richard E. , WANG, Nenghui , IWUAGWU, Christiana I. , ZUSI, Christopher, F. , MACOR, John E.
IPC分类号： C07D498/20 , C07D519/00 , A61K31/55 , A61P25/18 , A61P25/28
CPC分类号： C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic alpha7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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5.发明授权QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 有权CHINUKLIDINE衍生物如α-7尼古丁乙酰胆碱受体配体
公开(公告)号：EP2493892B1
公开(公告)日：2015-07-01
申请号：EP09744572.0
申请日：2009-10-29
发明人： COOK II, James H. , MCDONALD, Ivar, M. , KING, Dalton , OLSON, Richard, E. , WANG, Nenghui , IWUAGWU, Christiana, I. , ZUSI, F.,Christopher , MACOR, John, E.
IPC分类号： C07D498/20 , A61K31/439 , A61P25/28
CPC分类号： C07D498/20
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6.发明公开AZABICYCLIC COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 有权AYABICYCLISCHE化合物如α-7烟碱乙酰胆碱REZPETORLIGANDEN
公开(公告)号：EP2493894A1
公开(公告)日：2012-09-05
申请号：EP10776869.9
申请日：2010-10-26
发明人： MCDONALD, Ivar M. , MATE, Robert A. , COOK II, James H. , KING, Dalton , OLSON, Richard E. , WANG, Nenghui , IWUAGWU, Christiana I. , ZUSI, Christopher, F. , MACOR, John E.
IPC分类号： C07D498/20 , C07D519/00 , A61K31/55 , A61P25/18 , A61P25/28
CPC分类号： C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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7.发明公开AZABICYCLO[2.2.1]HEPTANE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 有权亚氨基胆碱[2.2.1] HEPTANVERBINDUNGEN ALS ALPHA-7-非诺贝特 - 乙酰胆碱酯酶REZPETORLIGANDEN
公开(公告)号：EP2493893A1
公开(公告)日：2012-09-05
申请号：EP10774092.0
申请日：2010-10-25
发明人： MCDONALD, Ivar M. , MATE, Robert A. , COOK II, James H. , KING, Dalton , OLSON, Richard E. , WANG, Nenghui , IWUAGWU, Christiana I. , ZUSI, F. Christopher , HILL, Matthew D. , FANG, Haiquan , MACOR, John E.
IPC分类号： C07D498/20 , C07D519/00 , A61K31/439 , A61P25/18 , A61P25/28
CPC分类号： C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including Ia, Ib, Ic, or Id, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders (Formula I).
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