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公开(公告)号：EP4149939A1
公开(公告)日：2023-03-22
申请号：EP21730348.6
申请日：2021-05-10
发明人： JALAGAM, Prasada Rao , NARA, Susheel Jethanand , PANDA, Manoranjan , NATESAN, Murugesan , DEVASTHALE, Pratik
IPC分类号： C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04 , C07D487/08 , A61P1/16 , A61P9/00 , A61P17/00 , A61P29/00 , A61P35/00 , A61K31/4192
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公开(公告)号：EP3954681A1
公开(公告)日：2022-02-16
申请号：EP21193297.5
申请日：2017-01-13
发明人： SMITH II, Leon M. , LADZIATA, Vladimir , DELUCCA, Indawati , PINTO, Donald, J. P. , ORWAT, Michael J. , DILGER, Andrew K. , PABBISETTY, Kumar Balashanmuga , YANG, Wu , SHAW, Scott A. , GLUNZ, Peter W. , PANDA, Manoranjan
IPC分类号： C07D401/14 , A61K31/437 , A61K31/4427 , C07D231/12 , C07D231/18 , C07D231/54 , C07D401/12 , C07D413/12 , C07D471/04 , C07D471/12 , C07D513/04 , C07D213/64
摘要： The present invention provides compounds of Formula (I):
or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.-
公开(公告)号：EP3929194A1
公开(公告)日：2021-12-29
申请号：EP21175085.6
申请日：2018-05-31
发明人： YADAV, Navnath Dnyanoba , BHIDE, Rajeev S. , BORA, Rajesh Onkardas , GUNAGA, Prashantha , PANDA, Manoranjan , PRIESTLEY, Eldon Scott , RICHTER, Jeremy
IPC分类号： C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , A61P9/00 , A61K31/5355 , A61K31/53 , A61K31/495
摘要： Disclosed are compounds of Formula (I)
or a salt thereof, wherein R 1 is:
each W is independently NR 1b or O; Z is a bond or CHR 1d ; and R 1 , R 2 , R d , R 3a , R 3b , L 1 , B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.-
公开(公告)号：EP4146646A1
公开(公告)日：2023-03-15
申请号：EP21727712.8
申请日：2021-05-04
发明人： JALAGAM, Prasada Rao , NAIR, Satheesh Kesavan , NARA, Susheel Jethanand , PANDA, Manoranjan , DEVASTHALE, Pratik , REGUEIRO-REN, Alicia
IPC分类号： C07D407/14 , C07H17/02 , A61P29/00 , A61K31/4192
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公开(公告)号：EP4103559A1
公开(公告)日：2022-12-21
申请号：EP21709851.6
申请日：2021-02-11
发明人： SELVAKUMAR, Kumaravel , PAIDI, Venkatram Reddy , THANGATHIRUPATHY, Srinivasan , KUMAR CM, Vijaya , ALAJANGI, Tirupathi, Rao , SURA, Mallikarjun, Reddy , MAHADEVU, Krishna , SISTLA, Ramesh, Kumar , AGARWAL, Piyush , SUBBIAH KARUPPIAH, Arul, Mozhi , NAIR, Jalathi, S. , MORAMPUDI, Ooha , PANDA, Manoranjan , TINO, Joseph, A. , CHERNEY, Robert, J. , DUNCIA, John, V. , GARDNER, Daniel, S. , DHAR, T., G., Murali , ROSS, Audrey, Graham , GORMISKY, Paul, E. , ZHU, Xiao , SELETSKY, Boris, M. , ANTROPOW, Alyssa, H. , NIU, Deqiang , ZHU, Zhengdong , MIAO, Guobin , CUERVO, Julio, Hernán
IPC分类号： C07D401/14 , A61K31/41 , C07D403/14 , C07D413/14 , A61P35/00 , A61P19/00 , C07D407/14 , C07D409/14
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公开(公告)号：EP3402790A1
公开(公告)日：2018-11-21
申请号：EP17701785.2
申请日：2017-01-13
发明人： SMITH II, Leon M. , LADZIATA, Vladimir , DELUCCA, Indawati , PINTO, Donald, J., P. , ORWAT, Michael J. , DILGER, Andrew K. , PABBISETTY, Kumar Balashanmuga , YANG, Wu , SHAW, Scott A. , GLUNZ, Peter W. , PANDA, Manoranjan
IPC分类号： C07D401/14 , A61K31/437 , A61K31/4427 , C07D231/12 , C07D231/18 , C07D231/54 , C07D401/12 , C07D413/12 , C07D471/04 , C07D471/12 , C07D513/04 , C07D213/64
CPC分类号： C07D471/04 , C07D213/64 , C07D231/12 , C07D231/18 , C07D231/54 , C07D401/12 , C07D401/14 , C07D413/12 , C07D471/12 , C07D513/04
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
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公开(公告)号：EP3953349A1
公开(公告)日：2022-02-16
申请号：EP20722856.0
申请日：2020-04-08
发明人： LIU, Chunjian , FENG, Jianxin , DEVASTHALE, Pratik , MURUGESAN, Natesan , ELLSWORTH, Bruce, A. , REGUEIRO-REN, Alicia , NARA, Susheel Jethanand , JALAGAM, Prasada Rao , PANDA, Manoranjan
IPC分类号： C07D405/04 , C07D407/14 , C07D409/14 , C07D417/14 , A61K31/4192 , A61P1/16 , A61P9/00 , A61P17/00 , A61P29/00 , A61P35/00
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公开(公告)号：EP3535258A1
公开(公告)日：2019-09-11
申请号：EP17801548.3
申请日：2017-11-02
发明人： GUNAGA, Prashantha , BHIDE, Rajeev S. , BORA, Rajesh Onkardas , PANDA, Manoranjan , YADAV, Navnath Dnyanoba , PRIESTLEY, Eldon Scott , RICHTER, Jeremy
IPC分类号： C07D405/14 , C07D413/14 , C07D417/14 , A61P13/02 , A61P9/00 , A61K31/444 , A61K31/4439
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公开(公告)号：EP3807290A1
公开(公告)日：2021-04-21
申请号：EP19740100.3
申请日：2019-06-13
发明人： HARTZ, Richard A. , XU, Li , YOON, David S. , REGUEIRO-REN, Alicia , JALAGAM, Prasada Rao , PANDA, Manoranjan , NAIR, Satheesh Kesavan
IPC分类号： C07H17/02 , A61K31/7048 , A61K31/7052 , C07H17/04 , A61P29/00 , A61P43/00
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公开(公告)号：EP3630752A1
公开(公告)日：2020-04-08
申请号：EP18733083.2
申请日：2018-05-31
发明人： YADAV, Navnath Dnyanoba , BHIDE, Rajeev S. , BORA, Rajesh Onkardas , GUNAGA, Prashantha , PANDA, Manoranjan , PRIESTLEY, Eldon Scott , RICHTER, Jeremy
IPC分类号： C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , A61P9/00 , A61K31/5355 , A61K31/53 , A61K31/495
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