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公开(公告)号：EP3303396A1
公开(公告)日：2018-04-11
申请号：EP16729129.3
申请日：2016-05-26
发明人： CAI, Zhehong , CHAKRABORTY, Indrani , GARCIA, Marie-Michelle, Navarro , KEMPE, Thomas, D. , KORMAN, Alan, J. , KOZHICH, Alexander, T. , LEMAR, Hadia , MAURER, Mark , MILBURN, Christina, Maria , QUIGLEY, Michael , RODRIGUEZ, Maria , SHAO, Xiang , SRINIVASAN, Mohan , STEVENS, Brenda, L. , THUDIUM, Kent , WONG, Susan, Chien-Szu , GOKEMEIJER, Jochem , WANG, Xi-Tao , CHANG, Han , HUANG, Christine , JURE-KUNKEL, Maria , YANG, Zheng , FENG, Yan , GUIRNALDA, Patrick , LONBERG, Nils , BARNHART, Bryan C. , YAMNIUK, Aaron P. , HENNING, Karla A. , HAN, Michelle Minhua , LEI, Ming , SCHWEIZER, Liang , HATCHER, Sandra V. , RAJPAL, Arvind , AANUR, Praveen , SELBY, Mark J.
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2878 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61P35/00 , C07K16/2818 , C07K16/30 , C07K16/3023 , C07K16/3038 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/574
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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公开(公告)号：EP3463486A1
公开(公告)日：2019-04-10
申请号：EP17730305.4
申请日：2017-05-31
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公开(公告)号：EP3224277A1
公开(公告)日：2017-10-04
申请号：EP15805710.9
申请日：2015-11-24
发明人： MORIN, Paul, E. , DONNELLY, David , LIPOVSEK, Dasa , GOKEMEIJER, Jochem , JURE-KUNKEL, Maria, N. , FABRIZIO, David , WRIGHT, Martin, C. , DISCHINO, Douglas , BONACORSI, Samuel, J. , SMITH, Ralph, Adam , COHEN, Daniel
IPC分类号： C07K14/78 , C07K14/47 , G01N33/574
摘要： Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.
摘要翻译： 本文提供了特异性结合PD-L1的新型10Fn3结构域以及基于其的用于诊断的成像剂。
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公开(公告)号：EP3702367A1
公开(公告)日：2020-09-02
申请号：EP20150212.7
申请日：2015-11-24
发明人： MORIN, Paul, E. , DONNELLY, David , LIPOVSEK, Dasa , GOKEMEIJER, Jochem , JURE-KUNKEL, Maria, N. , FABRIZIO, David , WRIGHT, Martin, C. , DISCHINO, Douglas , BONACORSI, Samuel, J. , SMITH, Ralph, Adam , LAFONT, Virginie , COHEN, Daniel
IPC分类号： C07K14/78 , C07K14/47 , G01N33/574
摘要： Provided herein are novel 10 Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.
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公开(公告)号：EP3224277B1
公开(公告)日：2020-08-26
申请号：EP15805710.9
申请日：2015-11-24
发明人： MORIN, Paul, E. , DONNELLY, David , LIPOVSEK, Dasa , GOKEMEIJER, Jochem , JURE-KUNKEL, Maria, N. , FABRIZIO, David , WRIGHT, Martin, C. , DISCHINO, Douglas , BONACORSI, Samuel, J. , SMITH, Ralph, Adam , LAFONT, Virginie , COHEN, Daniel
IPC分类号： C07K14/78 , C07K14/47 , G01N33/574
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