公开(公告)号：EP3303396A1

公开(公告)日：2018-04-11

申请号：EP16729129.3

申请日：2016-05-26

申请人： Bristol-Myers Squibb Company

发明人： CAI, Zhehong ,  CHAKRABORTY, Indrani ,  GARCIA, Marie-Michelle, Navarro ,  KEMPE, Thomas, D. ,  KORMAN, Alan, J. ,  KOZHICH, Alexander, T. ,  LEMAR, Hadia ,  MAURER, Mark ,  MILBURN, Christina, Maria ,  QUIGLEY, Michael ,  RODRIGUEZ, Maria ,  SHAO, Xiang ,  SRINIVASAN, Mohan ,  STEVENS, Brenda, L. ,  THUDIUM, Kent ,  WONG, Susan, Chien-Szu ,  GOKEMEIJER, Jochem ,  WANG, Xi-Tao ,  CHANG, Han ,  HUANG, Christine ,  JURE-KUNKEL, Maria ,  YANG, Zheng ,  FENG, Yan ,  GUIRNALDA, Patrick ,  LONBERG, Nils ,  BARNHART, Bryan C. ,  YAMNIUK, Aaron P. ,  HENNING, Karla A. ,  HAN, Michelle Minhua ,  LEI, Ming ,  SCHWEIZER, Liang ,  HATCHER, Sandra V. ,  RAJPAL, Arvind ,  AANUR, Praveen ,  SELBY, Mark J.

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/2878 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3038 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/574

摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.