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公开(公告)号：EP3423494A1
公开(公告)日：2019-01-09
申请号：EP17712299.1
申请日：2017-03-03
发明人： BARNHART, Bryan, C. , KORMAN, Alan, J. , LONBERG, Nils , YAMNIUK, Aaron, P. , SRIVISAN, Mohan , HENNING, Karla, A. , LEI, Ming , SEGA, Emanuela , GOODENOUGH, Angela , JURE-KUNKEL, Maria , CHEN, Guodong , SACK, John, S. , HUANG, Richard, Y. , CORBETT, Martin, J. , MYERS, Joseph, E. Jr. , SCHWEIZER, Liang , HATCHER, Sandra, V. , ALTURA, Rachel , HUANG, Haichun , ZHANG, Pingping , HILT, Edward, J. , HEDRICK, Michael, Nathan
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公开(公告)号：EP2925350B1
公开(公告)日：2019-01-30
申请号：EP13811698.3
申请日：2013-12-03
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公开(公告)号：EP3304079A1
公开(公告)日：2018-04-11
申请号：EP16731700.7
申请日：2016-06-02
发明人： WANG, Xi-tao , ADELAKUN, Olufemi, A. , LEWIN, Anne, C. , KORMAN, Alan, J. , SELBY, Mark, J. , WANG, Changyu , HUANG, Haichun , HENNING, Karla, A. , LONBERG, Nils , SRINIVASAN, Mohan , HAN, Michelle, Minhua , CHEN, Guodong , HUANG, Richard , CHAKRABORTY, Indrani , WONG, Susan, Chien-Szu , LI, Huiming
IPC分类号： G01N33/566 , C07K16/28
摘要： Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.
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4.发明公开ENHANCING ANTI-CANCER ACTIVITY OF IMMUNOMODULATORY FC FUSION PROTEINS 审中-公开VERBESSERUNG DER ANTIKREBSWIRKUNG VON免疫调节剂FC-FUSIONSPROTEINEN
公开(公告)号：EP2925350A1
公开(公告)日：2015-10-07
申请号：EP13811698.3
申请日：2013-12-03
CPC分类号： C07K14/435 , A61K2039/505 , C07K16/2818 , C07K16/2875 , C07K16/2878 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2319/30
摘要： The present disclosure provides a method for enhancing the anti-tumor efficacy of an Fc fusion protein which binds specifically to a target, e.g., a co-inhibitory or co-stimulatory receptor of ligand, on a T cell in a subject afflicted with a cancer or a disease caused by an infectious agent and alters the activity of the immunomodulatory target, thereby potentiating an endogenous immune response against cells of the cancer or the infectious agent, wherein the method comprises selecting, designing or modifying the Fc region of the Fc fusion protein so as to enhance the binding of said Fc region to an activating Fc receptor (FcR). The disclosure also provides an Fc fusion protein produced by said method and its use in treating a subject afflicted with a cancer or a disease caused by an infectious agent.
摘要翻译： 本公开提供了一种增强Fc融合蛋白的抗肿瘤功效的方法，其特异性结合靶基因，例如配体的共抑制或共刺激受体，在患有癌症的受试者的T细胞上 或由感染因子引起的疾病并改变免疫调节靶的活性，从而增强针对癌细胞或感染因子的内源性免疫应答，其中所述方法包括选择，设计或修饰Fc融合蛋白的Fc区 以增强所述Fc区与活化Fc受体（FcR）的结合。 本公开还提供了通过所述方法产生的Fc融合蛋白，其具有增强受试者中癌症或感染因子的细胞的内源性免疫应答的增强能力。 本公开进一步提供了治疗受试者的方法，其包括向受试者施用治疗有效量的Fc融合蛋白，其中已经选择，设计或修饰了Fc融合蛋白的Fc区，以增加所述Fc融合蛋白的结合 Fc区到激活的FcR。
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公开(公告)号：EP4098662A1
公开(公告)日：2022-12-07
申请号：EP22167890.7
申请日：2018-05-24
发明人： YAMNIUK, Aaron, P. , KORMAN, Alan, J. , SELBY, Mark, J. , BARNHART, Bryan, C. , LONBERG, Nils , SRINIVASAN, Mohan , HENNING, Karla, A. , HAN, Michelle, Minhua , LEI, Ming , SCHWEIZER, Liang , HATCHER, Sandra, V , RAJPAL, Arvind
IPC分类号： C07K16/28
摘要： Provided herein are heavy chain constant regions (referred to as "modified heavy chain constant regions"), or functionally equivalent fragments thereof, that enhance biological properties of antibodies relative to the same antibodies in unmodified form. An exemplary modified heavy chain constant region includes an IgG2 hinge and three constant domains ( i.e., CHI, CH2, and CH3 domains), wherein one or more of the constant region domains are of a non-IgG2 isotype (e.g., IgG1, IgG3 or IgG4). The heavy chain constant region may comprise wildtype human IgG domain sequences, or variants of these sequences. Also provided herein are methods for enhancing certain biological properties of antibodies that comprise a non-IgG2 hinge, such as internalization, agonism and antagonism, wherein the method comprises replacing the non-IgG2 hinge of the antibody with an IgG2 hinge.
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公开(公告)号：EP3304079B1
公开(公告)日：2020-06-03
申请号：EP16731700.7
申请日：2016-06-02
发明人： WANG, Xi-tao , ADELAKUN, Olufemi, A. , LEWIN, Anne, C. , KORMAN, Alan, J. , SELBY, Mark, J. , WANG, Changyu , HUANG, Haichun , HENNING, Karla, A. , LONBERG, Nils , SRINIVASAN, Mohan , HAN, Michelle, Minhua , CHEN, Guodong , HUANG, Richard , CHAKRABORTY, Indrani , WONG, Susan, Chien-Szu , LI, Huiming
IPC分类号： G01N33/566 , C07K16/28
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公开(公告)号：EP3606959A2
公开(公告)日：2020-02-12
申请号：EP18720501.8
申请日：2018-04-05
发明人： ENGELHARDT, John, J. , SELBY, Mark, J. , KORMAN, Alan, J. , FEINGERSH, Mary, Diane , STEVENS, Brenda, L.
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
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公开(公告)号：EP3303396A1
公开(公告)日：2018-04-11
申请号：EP16729129.3
申请日：2016-05-26
发明人： CAI, Zhehong , CHAKRABORTY, Indrani , GARCIA, Marie-Michelle, Navarro , KEMPE, Thomas, D. , KORMAN, Alan, J. , KOZHICH, Alexander, T. , LEMAR, Hadia , MAURER, Mark , MILBURN, Christina, Maria , QUIGLEY, Michael , RODRIGUEZ, Maria , SHAO, Xiang , SRINIVASAN, Mohan , STEVENS, Brenda, L. , THUDIUM, Kent , WONG, Susan, Chien-Szu , GOKEMEIJER, Jochem , WANG, Xi-Tao , CHANG, Han , HUANG, Christine , JURE-KUNKEL, Maria , YANG, Zheng , FENG, Yan , GUIRNALDA, Patrick , LONBERG, Nils , BARNHART, Bryan C. , YAMNIUK, Aaron P. , HENNING, Karla A. , HAN, Michelle Minhua , LEI, Ming , SCHWEIZER, Liang , HATCHER, Sandra V. , RAJPAL, Arvind , AANUR, Praveen , SELBY, Mark J.
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2878 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61P35/00 , C07K16/2818 , C07K16/30 , C07K16/3023 , C07K16/3038 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/574
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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公开(公告)号：EP3630833A1
公开(公告)日：2020-04-08
申请号：EP18731658.3
申请日：2018-05-24
发明人： YAMNIUK, Aaron, P. , KORMAN, Alan, J. , SELBY, Mark, J. , BARNHART, Bryan, C. , LONBERG, Nils , SRINIVASAN, Mohan , HENNING, Karla, A. , HAN, Michelle, Minhua , LEI, Ming , SCHWEIZER, Liang , HATCHER, Sandra, V. , RAJPAL, Arvind
IPC分类号： C07K16/28
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10.发明公开
公开(公告)号：EP3377532A2
公开(公告)日：2018-09-26
申请号：EP16805668.7
申请日：2016-11-17
发明人： WANG, Changyu , LONBERG, Nils , KORMAN, Alan, J. , SELBY, Mark, J. , SRINIVASAN, Mohan , HENNING, Karla, A. , HAN, Michelle, Minhua , CHEN, Guodong , HUANG, Richard , CHAKRABORTY, Indrani , HUANG, Haichun , WONG, Susan, Chien-Szu , LI, Huiming , BARNHART, Bryan, C. , YAMNIUK, Aaron, P. , LEI, Ming , SCHWEIZER, Liang , HATCHER, Sandra, V. , RAJPAL, Arvind
CPC分类号： A61K39/39558 , A61K2039/507 , A61K2039/572 , A61P35/04 , C07K16/2818 , C07K16/2878 , C07K2317/21 , C07K2317/34 , C07K2317/732 , C07K2317/75 , C07K2317/77 , C07K2317/92 , G01N33/574 , G01N33/6863
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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