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1.发明授权UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS 有权FOR P2Y1受体的痛苦血栓SUITABLE尿素拮抗剂治疗
公开(公告)号：EP1751113B1
公开(公告)日：2010-03-10
申请号：EP05747470.2
申请日：2005-05-11
发明人： CHAO, Hannguang J. , TUERDI, Huji , HERPIN, Timothy , ROBERGE, Jacques Yves , LIU, Yalei , LAWRENCE, R. Michael , REHFUSS, Robert P. , CLARK, Charles G. , QIAO, Jennifer X. , GUNGOR, Timur , LAM, Patrick Y.S. , WANG, Tammy C. , RUEL, Rejean , L'HEUREUX, Alexandre L. , THIBEAULT, Carl , BOUTHILLIER, Gilles , SCHNUR, Dora M.
IPC分类号： C07D231/50 , C07D231/40 , C07D213/40 , C07D413/12 , C07D401/12 , C07D405/12 , C07D417/12 , C07D333/36 , A61K31/444 , A61P7/02
CPC分类号： C07D409/14 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07F7/1856
摘要： The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
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公开(公告)号：EP1684744A2
公开(公告)日：2006-08-02
申请号：EP04789264.1
申请日：2004-09-29
发明人： SHI, Yan , STEIN, Philip, D. , HAN, Wei , GUNGOR, Timur
IPC分类号： A61K31/40 , A61K31/41 , A61K31/44 , A61K31/404 , A61K31/4427 , C07D401/14
CPC分类号： C07D401/14 , C07D401/06 , C07D409/14 , C07D417/14
摘要： The present application describes pyrrolidine and piperidine derivatives or pharmaceutically acceptable salt forms thereof. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
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3.发明授权UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS 有权P2Y1受体的血栓形成莱顿治疗尿素拮抗剂
公开(公告)号：EP1750704B1
公开(公告)日：2009-07-22
申请号：EP05779448.9
申请日：2005-05-11
IPC分类号： A61K31/444
CPC分类号： C07D409/04 , C07D209/08 , C07D209/14 , C07D209/96 , C07D215/06 , C07D241/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D471/10
摘要： The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
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公开(公告)号：EP1706398B1
公开(公告)日：2014-05-21
申请号：EP05711663.4
申请日：2005-01-20
发明人： HERPIN, Timothy, F. , MORTON, George, C. , REHFUSS, Robert, P. , LAWRENCE, R., Michael , POSS, Michael, A. , ROBERGE, Jacques, Y. , GUNGOR, Timur
IPC分类号： C07D401/12 , C07D413/12 , C07D409/14 , C07D401/14 , C07D491/04 , C07D417/12 , C07D405/14 , C07D235/30 , C07D471/04 , C07D417/14 , C07D513/04 , C07D413/14 , C07D409/12 , A61K31/4184 , A61K31/423
CPC分类号： C07D401/12 , C07D235/30 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/04 , C07D513/04
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5.发明公开N-LINKED HETEROCYCLIC ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS 有权N-连接的P2Y1受体的拮抗剂杂环血栓形成莱顿治疗
公开(公告)号：EP1896466A1
公开(公告)日：2008-03-12
申请号：EP06774067.0
申请日：2006-06-26
IPC分类号： C07D417/12 , C07D401/04 , C07D401/10 , C07D401/12 , C07D417/14 , A61K31/40 , A61K31/427 , A61P7/00
CPC分类号： C07D471/10 , C07D401/04 , C07D401/12 , C07D417/12 , C07D417/14
摘要： The present invention provides novel ureas containing N/-aryl or N-heteroaryl substituted heterocycles of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are defined herein. These compounds are selective inhibitors of the human P2Y, receptor which can be used as medicaments for treating thromboembolic disorders.
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6.发明公开UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS 有权P2Y1受体的血栓形成莱顿治疗尿素拮抗剂
公开(公告)号：EP1750704A2
公开(公告)日：2007-02-14
申请号：EP05779448.9
申请日：2005-05-11
IPC分类号： A61K31/444
CPC分类号： C07D409/04 , C07D209/08 , C07D209/14 , C07D209/96 , C07D215/06 , C07D241/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D471/10
摘要： The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
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7.发明授权N-LINKED HETEROCYCLIC ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS 有权N-连接的P2Y1受体的拮抗剂杂环血栓形成莱顿治疗
公开(公告)号：EP1896466B1
公开(公告)日：2011-04-13
申请号：EP06774067.0
申请日：2006-06-26
IPC分类号： C07D417/12 , C07D401/04 , C07D401/10 , C07D401/12 , C07D417/14 , A61K31/40 , A61K31/427 , A61P7/00
CPC分类号： C07D471/10 , C07D401/04 , C07D401/12 , C07D417/12 , C07D417/14
摘要： The present invention provides novel ureas containing N/-aryl or N-heteroaryl substituted heterocycles of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are defined herein. These compounds are selective inhibitors of the human P2Y, receptor which can be used as medicaments for treating thromboembolic disorders.
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8.发明公开SULFONYLAMINOVALEROLACTAMS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS 审中-公开SULFONYLAMINOVALEROLACTAME及其衍生物Xa因子抑制剂
公开(公告)号：EP1667635A2
公开(公告)日：2006-06-14
申请号：EP04817779.4
申请日：2004-09-29
发明人： HAN, Wei , HU, Zilun , GUNGOR, Timur
IPC分类号： A61K6/00
CPC分类号： C07D401/04 , C07D207/38 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula (Ia-If) or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono-or bicyclic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
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9.发明公开LACTAM-CONTAINING CYCLIC DIAMINES AND DERIVATIVES AS FACTOR XA INHIBITORS 审中-公开含有内酰胺环二胺以及由此派生的Xa因子抑制剂
公开(公告)号：EP1603572A1
公开(公告)日：2005-12-14
申请号：EP04757541.0
申请日：2004-03-17
IPC分类号： A61K31/535 , A61K31/445 , A61K31/44 , C07D413/00 , C07D401/00 , C07D411/00
CPC分类号： C07D213/64 , C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present application describes lactam-containing cyclic diamines and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein M is a non-aromatic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trysin-like serine proteases, specifically factor Xa.
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