公开(公告)号：EP1531810B1

公开(公告)日：2012-02-01

申请号：EP03763345.0

申请日：2003-07-08

申请人： Bristol-Myers Squibb Company

发明人： CHENG, Peter, T., W. ,  CHEN, Sean ,  DING, Charles, Z. ,  HERPIN, Timothy, F.

IPC分类号： A61K31/41 ,  A61K31/42 ,  A61K31/50 ,  A61K31/52 ,  A61K31/435 ,  C07D249/06 ,  C07D263/32 ,  C07D233/64 ,  C07D271/06 ,  C07D413/12 ,  A61P3/10

CPC分类号： C07D233/64 ,  C07D249/06 ,  C07D263/32 ,  C07D271/06 ,  C07D413/12

摘要： Compounds are provided which are useful as antidiabetic agents and antiobesity agents and have the structure (I) wherein m is 0, 1 or 2; n is 0, 1 or 2; Q is C or N; A is (CH2)x where x is 1 to 5, or A is (CH2)x1 where x1 is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is -(CH2)x2-O-(CH2)x3- where x2 is 0 to 5 and x3 is 0 to 5, provided that at least one of x2 and x3 is other than 0; B is a bond or is (CH2)x4 where x4 is 1 to 5; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4, X5 and X6 is C, and specifically excluding the structure (II) where X2 = N, X3 = C, X4 = O or S, Z = o or a bond; R1 is H or alkyl; R2 is H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; R2a, R2b and R2c may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; and R3 and Y are as defined herein, which compounds are useful in treating diabetes and obesity.

公开(公告)号：EP1656368A2

公开(公告)日：2006-05-17

申请号：EP03763485.4

申请日：2003-07-02

申请人： Bristol-Myers Squibb Company

发明人： CHENG, Peter, T. W. ,  CHEN, Sean ,  DEVASTHALE, Pratik ,  DING, Charles, Z. ,  HERPIN, Timothy, F. ,  WU, Shung ,  ZHANG, Hao ,  WANG, Wei ,  YE, Xiang-Yang

IPC分类号： C07D403/06 ,  C07D403/08 ,  C07D403/10 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  A61K31/422 ,  A61K31/397 ,  A61P35/00

CPC分类号： C07D413/12 ,  C07D413/14

摘要： Formula, wherein Z1 is (CH2)q or C=O; Z2 is (CH2)p or C=O; D is -CH= or C=O or (CH2)m where m is 0, 1, 2 or 3; n = 0, 1 or 2; p = 1 or 2; q = 0, 1 or 2; Q is C or N; A is (CH2)x where x is 1 to 5, or A is (CH2)x1, where x1 is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is -(CH2)x2-O-(CH2)x3 - where x2 is 0 to 5 and x3 is 0 to 5, provided that at least one of x2 and x3 is other than 0; B is a bond or is (CH2)x4 where x4 is 1 to 5; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4 X5 and X6 is C. R1 is H or alkyl; R2 is H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; R2a, R2b and R2c may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; and R3, E, Z and Y are as defined herein.

公开(公告)号：EP1706398B1

公开(公告)日：2014-05-21

申请号：EP05711663.4

申请日：2005-01-20

申请人： Bristol-Myers Squibb Company

发明人： HERPIN, Timothy, F. ,  MORTON, George, C. ,  REHFUSS, Robert, P. ,  LAWRENCE, R., Michael ,  POSS, Michael, A. ,  ROBERGE, Jacques, Y. ,  GUNGOR, Timur

IPC分类号： C07D401/12 ,  C07D413/12 ,  C07D409/14 ,  C07D401/14 ,  C07D491/04 ,  C07D417/12 ,  C07D405/14 ,  C07D235/30 ,  C07D471/04 ,  C07D417/14 ,  C07D513/04 ,  C07D413/14 ,  C07D409/12 ,  A61K31/4184 ,  A61K31/423

CPC分类号： C07D401/12 ,  C07D235/30 ,  C07D401/14 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D513/04

公开(公告)号：EP1531810A2

公开(公告)日：2005-05-25

申请号：EP03763345.0

申请日：2003-07-08

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： CHENG, Peter, T., W. ,  CHEN, Sean ,  DING, Charles, Z. ,  HERPIN, Timothy, F.

IPC分类号： A61K31/41 ,  A61K31/42 ,  A61K31/50 ,  A61K31/52 ,  A61K31/435

CPC分类号： C07D233/64 ,  C07D249/06 ,  C07D263/32 ,  C07D271/06 ,  C07D413/12

摘要： Compounds are provided which are useful as antidiabetic agents and antiobesity agents and have the structure (I) wherein m is 0, 1 or 2; n is 0, 1 or 2; Q is C or N; A is (CH2)x where x is 1 to 5, or A is (CH2)x1 where x1 is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is -(CH2)x2-O-(CH2)x3- where x2 is 0 to 5 and x3 is 0 to 5, provided that at least one of x2 and x3 is other than 0; B is a bond or is (CH2)x4 where x4 is 1 to 5; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4, X5 and X6 is C, and specifically excluding the structure (II) where X2 = N, X3 = C, X4 = O or S, Z = o or a bond; R1 is H or alkyl; R2 is H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; R2a, R2b and R2c may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; and R3 and Y are as defined herein, which compounds are useful in treating diabetes and obesity.

公开(公告)号：EP1448187A2

公开(公告)日：2004-08-25

申请号：EP02789910.3

申请日：2002-11-27

申请人： Bristol-Myers Squibb Company

发明人： LIU, Chunjian ,  DHAR, Murali, T., G. ,  GU, Henry, H. ,  IWANOWICZ, Edwin, J. ,  LEFTHERIS, Katerina ,  PITTS, William, J. ,  HERPIN, Timothy, F. ,  PI, Zulan ,  BISACCHI, Gregory, S.

IPC分类号： A61K31/33 ,  A61K31/505 ,  A61K31/53 ,  A61K31/425 ,  A61K31/42 ,  A61K31/41 ,  C07D239/00 ,  C07D239/02 ,  C07D251/00 ,  C07D253/00 ,  C07D271/00 ,  C07D413/00

CPC分类号： C07D413/12 ,  A61K45/06 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D263/32 ,  C07D263/48 ,  C07D413/14 ,  C07D417/12

摘要： Compounds having the formula (I), are effective as inhibitors of IMPDH enzyme and/or serine protease Factor VIIa, wherein B is a monocyclic or bicyclic carbocyclic or heterocyclic ring, D is a monocyclic or bicyclic carbocyclic or heterocyclic ring except when A is a heterocyclic ring, then D is a heterocyclic ring system, R is hydrogen or C1-4alkyl, and A, R1, R2 and R4 are as defined in the specification.