公开(公告)号：EP1644384B1

公开(公告)日：2012-10-31

申请号：EP03812974.8

申请日：2003-12-10

申请人： Bristol-Myers Squibb Company

发明人： PENDRI, Yadagiri, R. ,  CHEN, Chung-Pin, H. ,  PATEL, Sunil, S. ,  EVANS, Jeffrey, M. ,  LIANG, Jing ,  KRONENTHAL, David, R. ,  POWERS, Gerald, L. ,  PRASAD, Siva, Josyula ,  BIEN, Jeffrey, T. ,  SHI, Zhongping ,  PATEL, Ramesh, N. ,  CHAN, Yeung, Y. ,  RIJHWANI, Sushil, K. ,  SINGH, Ambarish, K. ,  WANG, Shaopeng ,  STOJANOVIC, Milan ,  POLNIASZEK, Richard ,  LEWIS, Charles ,  THOTTATHIL, John ,  KRISHNAMURTY, Dhileepkumar ,  ZHOU, Maotang X. ,  VEMISHETTI, Purushotham ,  BANERJEE, Amit ,  KUCERA, David, J.

IPC分类号： C07D473/18 ,  C07F7/08 ,  C07F7/18

CPC分类号： C07F7/1856 ,  C07D473/18 ,  C07F7/0812 ,  C07F7/0814 ,  C07F7/0818 ,  C07F7/0827 ,  C07F7/083

公开(公告)号：EP1805176A2

公开(公告)日：2007-07-11

申请号：EP05805626.8

申请日：2005-09-27

申请人： Bristol-Myers Squibb Company

发明人： MUDRYK, Boguslaw, M. ,  CUNIERE, Nicolas ,  HSIEH, Dau-Ming ,  ROSSANO, Lucius ,  LIANG, Jing ,  CHEN, Bang-Chi ,  ZHANG, Huiping ,  ZHAO, Rulin ,  WANG, Bei ,  DAVID, Adrian

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P7/02

CPC分类号： C07D471/04

摘要： A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. Formula (I). These compounds can be useful as factor Xa inhibitors.

公开(公告)号：EP1644384A2

公开(公告)日：2006-04-12

申请号：EP03812974.8

申请日：2003-12-10

申请人： Bristol-Myers Squibb Company

发明人： PENDRI, Yadagiri, R. ,  CHEN, Chung-Pin, H. ,  PATEL, Sunil, S. ,  EVANS, Jeffrey, M. ,  LIANG, Jing ,  KRONENTHAL, David, R. ,  POWERS, Gerald, L. ,  PRASAD, Siva, Josyula ,  BIEN, Jeffrey, T. ,  SHI, Zhongping ,  PATEL, Ramesh, N. ,  CHAN, Yeung, Y. ,  RIJHWANI, Sushil, K. ,  SINGH, Ambarish, K. ,  WANG, Shaopeng ,  STOJANOVIC, Milan ,  POLNIASZEK, Richard ,  LEWIS, Charles ,  THOTTATHIL, John ,  KRISHNAMURTY, Dhileepkumar ,  ZHOU, Maotang X. ,  VEMISHETTI, Purushotham ,  BANERJEE, Amit ,  KUCERA, David, J.

IPC分类号： C07F7/08 ,  C07F7/18 ,  C07D473/18

CPC分类号： C07F7/1856 ,  C07D473/18 ,  C07F7/0812 ,  C07F7/0814 ,  C07F7/0818 ,  C07F7/0827 ,  C07F7/083

摘要： Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.