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1.发明公开POLYNUCLEOTIDE ENCODING A NOVEL CYSTEINE PROTEASE OF THE CALPAIN SUPERFAMILY, CAN-12, AND VARIANTS THEREOF 审中-公开NEW半胱氨酸蛋白酶钙蛋白酶超家族的多核苷酸编码，CAN-12，及其变体
公开(公告)号：EP1567642A2
公开(公告)日：2005-08-31
申请号：EP02731232.1
申请日：2002-04-02
发明人： CHEN, Jian , DUCLOS, Franck , FEDER, John, N. , NELSON, Thomas, C. , SEILER, Steven , VAZ, Roy, J.
IPC分类号： C12N9/64 , C12N15/57 , C12N15/63 , C12N15/70 , C12N15/74 , C12N15/79 , C12P21/06 , A61K38/48
CPC分类号： C12N9/6472 , A61K38/00 , C07K2299/00 , Y02A90/26
摘要： The present invention provides novel polynucleotides encoding CAN-12 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of CAN-12 polypeptides, CAN-12v1 and CAN-12v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel CAN-12, CAN-12v1, and CAN-12v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly neuro- and musculo-degenerative conditions. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
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公开(公告)号：EP1089973B1
公开(公告)日：2005-11-09
申请号：EP99930402.5
申请日：1999-06-18
发明人： BISACCHI, Gregory , SLUSARCHYK, William, A. , TREUNER, Uwe , SUTTON, James, C. , ZAHLER, Robert , SEILER, Steven , KRONENTHAL, David, R. , RANDAZZO, Michael, E. , XU, Zhongmin , SHI, Zhongping , SCHWINDEN, Mark, D.
IPC分类号： C07D205/08 , C07D205/09 , C07D403/12 , C07D401/06 , C07D403/06 , A61K31/395
CPC分类号： C07D403/12 , C07D205/08
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公开(公告)号：EP1089973A1
公开(公告)日：2001-04-11
申请号：EP99930402.5
申请日：1999-06-18
发明人： BISACCHI, Gregory , SLUSARCHYK, William, A. , TREUNER, Uwe , SUTTON, James, C. , ZAHLER, Robert , SEILER, Steven , KRONENTHAL, David, R. , RANDAZZO, Michael, E. , XU, Zhongmin , SHI, Zhongping , SCHWINDEN, Mark, D.
IPC分类号： C07D205/08 , C07D205/09
CPC分类号： C07D403/12 , C07D205/08
摘要： Compounds of formulae (I), (II), (III).
摘要翻译： 式（I），（II），（III）的化合物。
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公开(公告)号：EP1334179A2
公开(公告)日：2003-08-13
申请号：EP01996599.5
申请日：2001-11-14
发明人： CHEN, Jian , FEDER, John, N. , NELSON, Thomas , SEILER, Steven , BASSOLINO, Donna, A , CHENEY, Daniel, L. , DUCLOS, Frank
IPC分类号： C12N9/00
CPC分类号： C07K14/8121 , A61K38/00 , C07K2299/00
摘要： The present invention provides novel polynucleotides encoding LSI-01 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention furtherrelates to diagnostic and therapeutic methods for applying these novel LSI-01 polypeptides to the diagnosis, treatment, and/or prevention of various diseas and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
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