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1.发明公开
公开(公告)号：EP3277670A1
公开(公告)日：2018-02-07
申请号：EP16715777.5
申请日：2016-04-01
发明人： BALOG, James Aaron , CHERNEY, Emily Charlotte , GUO, Weiwei , HUANG, Audris , MARKWALDER, Jay A. , SEITZ, Steven P. , SHAN, Weifang , WILLIAMS, David K. , MURUGESAN, Natesan , NARA, Susheel Jethanand , ROY, Saumya , THANGAVEL, Soodamani , SISTLA,Ramesh Kumar , CHERUKU, Srinivas , THANGATHIRUPATHY, Srinivasan , KANYABOINA, Yadagiri , PULICHARLA, Nagalakshmi
IPC分类号： C07D309/14 , C07D317/66 , C07D401/12 , C07D405/12 , C07D239/42 , C07D261/14 , C07D487/04 , A61K31/17 , A61P35/00 , C07D335/02 , C07C229/00 , A61K31/136 , C07D409/12
CPC分类号： C07C275/40 , A61K31/17 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07C229/42 , C07C233/81 , C07C235/38 , C07C235/56 , C07C255/57 , C07C255/58 , C07C275/30 , C07C275/42 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/08 , C07D211/14 , C07D239/34 , C07D239/47 , C07D265/30 , C07D265/36 , C07D277/64 , C07D295/155 , C07D307/22 , C07D309/04 , C07D309/14 , C07D317/46 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：EP3016932B1
公开(公告)日：2019-02-27
申请号：EP14745007.6
申请日：2014-07-01
发明人： MARKWALDER, Jay A. , SEITZ, Steven P. , BALOG, James Aaron , HUANG, Audris , MANDAL, Sunil Kumar , WILLIAMS, David K. , HART, Amy C. , DONNELL, Jennifer
IPC分类号： C07C275/42 , C07D213/75 , C07C311/51 , C07D257/04 , A61K31/17 , A61K31/18 , A61K31/41 , A61K31/44 , A61P35/00
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公开(公告)号：EP3277671A1
公开(公告)日：2018-02-07
申请号：EP16715778.3
申请日：2016-04-01
发明人： BALOG, James Aaron , CHERNEY, Emily Charlotte , MARKWALDER, Jay A. , SEITZ, Steven P. , SHAN, Weifang , WILLIAMS, David K. , NARA, Susheel Jethanand , ROY, Saumya , THANGAVEL, Soodamani , SISTLA, Ramesh Kumar , CHERUKU, Srinivas , THANGATHIRUPATHY, Srinivasan , KANYABOINA, Yadagiri , PULICHARLA, Nagalakshmi , HUANG, Audris
IPC分类号： C07D309/14 , C07D405/12 , C07D487/04 , A61P35/00 , C07D413/12 , C07D487/08 , C07D265/30 , C07D211/08 , C07D295/155 , C07D407/12 , C07D207/08 , C07D307/22 , C07D335/02 , A61K31/35
CPC分类号： C07C275/40 , A61K31/17 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07C229/42 , C07C233/81 , C07C235/38 , C07C235/56 , C07C255/57 , C07C255/58 , C07C275/30 , C07C275/42 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/08 , C07D211/14 , C07D239/34 , C07D239/47 , C07D265/30 , C07D265/36 , C07D277/64 , C07D295/155 , C07D307/22 , C07D309/04 , C07D309/14 , C07D317/46 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：EP3016932A1
公开(公告)日：2016-05-11
申请号：EP14745007.6
申请日：2014-07-01
发明人： MARKWALDER, Jay A. , SEITZ, Steven P. , BALOG, James Aaron , HUANG, Audris , MANDAL, Sunil Kumar , WILLIAMS, David K. , HART, Amy C. , INGHRIM, Jennifer
IPC分类号： C07C275/42 , C07D213/75 , C07C311/51 , C07D257/04 , A61K31/17 , A61K31/18 , A61K31/41 , A61K31/44 , A61P35/00
CPC分类号： C07C275/42 , A61K31/18 , A61K31/196 , A61K31/277 , A61K31/343 , A61K31/41 , A61K31/4418 , A61K31/444 , A61K45/06 , C07C311/09 , C07C311/51 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D213/75 , C07D213/79 , C07D257/04 , C07D307/79 , C07D307/86 , C07D401/04
摘要： There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine 2,3-di-oxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
摘要翻译： 公开了调节或抑制吲哚胺2,3-二加氧酶（IDO）的酶活性的式（I）化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或 使用本发明化合物的炎症性疾病。
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公开(公告)号：EP2970155B1
公开(公告)日：2018-04-25
申请号：EP14729491.2
申请日：2014-03-12
发明人： BALOG, James Aaron , HUANG, Audris , CHEN, Bin , CHEN, Libing , SEITZ, Steven P. , HART, Amy C. , MARKWALDER, Jay A.
IPC分类号： C07D261/02 , C07C233/07 , C07D239/22 , C07D213/60
CPC分类号： A61K31/196 , A61K31/18 , A61K31/216 , A61K31/27 , A61K31/36 , A61K31/41 , A61K31/42 , A61K31/4245 , A61K31/44 , A61K31/498 , A61K31/505 , A61K45/06 , A61N5/10 , C07B2200/07 , C07C69/743 , C07C233/55 , C07C235/38 , C07C255/44 , C07C255/57 , C07C271/28 , C07C275/42 , C07C311/47 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/02 , C07C2602/08 , C07C2602/14 , C07C2602/42 , C07D213/56 , C07D213/75 , C07D213/84 , C07D239/42 , C07D241/42 , C07D257/04 , C07D261/08 , C07D261/14 , C07D271/12 , C07D317/66 , Y02A50/411 , Y02A50/414
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：EP2552922A1
公开(公告)日：2013-02-06
申请号：EP11714884.1
申请日：2011-03-30
发明人： MARKWALDER, Jay A. , FINK, Brian E. , GAVAI, Ashvinikumar V. , HE, Liqi , KIM, Soong-Hoon , SEITZ, Steven P.
IPC分类号： C07D487/04 , A61P35/00 , A61K31/53
CPC分类号： C07D487/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D407/04 , C07D407/14 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) pyrrolotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
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公开(公告)号：EP3039020A1
公开(公告)日：2016-07-06
申请号：EP14766038.5
申请日：2014-08-26
发明人： MARKWALDER, Jay A. , SEITZ, Steven P. , BALOG, James Aaron , HUANG, Audris , WILLIAMS, David K. , CHEN, Libing , MANDAL, Sunil Kumar , SRIVASTAVA, Shefali
IPC分类号： C07D403/12 , C07D309/14 , C07D215/06 , C07D231/12 , C07D333/10 , C07D401/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D257/04 , C07D277/22 , C07C13/00 , A61K31/416 , A61P37/02
CPC分类号： C07D257/04 , A61K31/17 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/451 , A61K31/4709 , A61K31/497 , A61K31/50 , A61K31/506 , A61K31/5375 , A61K45/06 , C07B59/002 , C07C275/42 , C07C311/05 , C07C311/09 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D211/14 , C07D215/06 , C07D231/12 , C07D237/20 , C07D277/22 , C07D309/14 , C07D333/10 , C07D333/38 , C07D401/10 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D417/12
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.
摘要翻译： 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或自身免疫性疾病的方法，其利用 发明。
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公开(公告)号：EP2970155A1
公开(公告)日：2016-01-20
申请号：EP14729491.2
申请日：2014-03-12
发明人： BALOG, James Aaron , HUANG, Audris , CHEN, Bin , CHEN, Libing , SEITZ, Steven P. , HART, Amy C. , MARKWALDER, Jay A.
IPC分类号： C07D261/02 , C07C233/07 , C07D239/22 , C07D213/60
CPC分类号： A61K31/196 , A61K31/18 , A61K31/216 , A61K31/27 , A61K31/36 , A61K31/41 , A61K31/42 , A61K31/4245 , A61K31/44 , A61K31/498 , A61K31/505 , A61K45/06 , A61N5/10 , C07B2200/07 , C07C69/743 , C07C233/55 , C07C235/38 , C07C255/44 , C07C255/57 , C07C271/28 , C07C275/42 , C07C311/47 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/02 , C07C2602/08 , C07C2602/14 , C07C2602/42 , C07D213/56 , C07D213/75 , C07D213/84 , C07D239/42 , C07D241/42 , C07D257/04 , C07D261/08 , C07D261/14 , C07D271/12 , C07D317/66 , Y02A50/411 , Y02A50/414
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
摘要翻译： 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和使用所述化合物治疗增殖性疾病如癌症，病毒感染和/或炎症性疾病的方法 发明。
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公开(公告)号：EP3039020B1
公开(公告)日：2017-07-19
申请号：EP14766038.5
申请日：2014-08-26
发明人： MARKWALDER, Jay A. , SEITZ, Steven P. , BALOG, James Aaron , HUANG, Audris , WILLIAMS, David K. , CHEN, Libing , MANDAL, Sunil Kumar , SRIVASTAVA, Shefali
IPC分类号： C07D403/12 , C07D309/14 , C07D215/06 , C07D231/12 , C07D333/10 , C07D401/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D257/04 , C07D277/22 , C07C13/00 , A61K31/416 , A61P37/02
CPC分类号： C07D257/04 , A61K31/17 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/451 , A61K31/4709 , A61K31/497 , A61K31/50 , A61K31/506 , A61K31/5375 , A61K45/06 , C07B59/002 , C07C275/42 , C07C311/05 , C07C311/09 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D211/14 , C07D215/06 , C07D231/12 , C07D237/20 , C07D277/22 , C07D309/14 , C07D333/10 , C07D333/38 , C07D401/10 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D417/12
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.
摘要翻译： 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和使用该化合物治疗增殖性疾病如癌症，病毒感染和/或自身免疫疾病的方法 发明。
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公开(公告)号：EP3019488A1
公开(公告)日：2016-05-18
申请号：EP14747209.6
申请日：2014-07-10
IPC分类号： C07D401/10 , C07C255/58 , C07D401/12 , C07D403/10 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D257/04 , C07D261/08 , C07D487/08 , C07C237/40 , A61K31/196 , A61K31/277 , A61K31/41
CPC分类号： A61K31/196 , A61K31/41 , A61K31/4155 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/06 , A61N5/10 , C07C233/55 , C07C255/57 , C07C2601/14 , C07D257/04 , C07D261/08 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/08 , Y02A50/411 , Y02A50/414
摘要： There are disclosed compounds of Formula (I) that modulate or inhibit the enzymatic activity of indoleamine 2,3-di-oxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.
摘要翻译： 公开了调节或抑制吲哚胺2,3-二加氧酶（IDO）的酶活性的式（I）化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或 使用本发明化合物的自身免疫性疾病。
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