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公开(公告)号：EP3362441A1
公开(公告)日：2018-08-22
申请号：EP16790475.4
申请日：2016-10-13
发明人： ISLAM, Imadul , THANGATHIRUPATHY, Srinivasan , WARRIER, Jayakumar Sankara , CHERUKU, Srinivas , SHETTY, Poornima , GUPTA, Grandhi Venkat Ram Krishna Mohan , MACOR, John E.
IPC分类号： C07D401/12 , C07D471/08 , A61K31/496 , A61P25/02 , A61P25/24 , A61P25/28
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
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2.发明公开
公开(公告)号：EP3277670A1
公开(公告)日：2018-02-07
申请号：EP16715777.5
申请日：2016-04-01
发明人： BALOG, James Aaron , CHERNEY, Emily Charlotte , GUO, Weiwei , HUANG, Audris , MARKWALDER, Jay A. , SEITZ, Steven P. , SHAN, Weifang , WILLIAMS, David K. , MURUGESAN, Natesan , NARA, Susheel Jethanand , ROY, Saumya , THANGAVEL, Soodamani , SISTLA,Ramesh Kumar , CHERUKU, Srinivas , THANGATHIRUPATHY, Srinivasan , KANYABOINA, Yadagiri , PULICHARLA, Nagalakshmi
IPC分类号： C07D309/14 , C07D317/66 , C07D401/12 , C07D405/12 , C07D239/42 , C07D261/14 , C07D487/04 , A61K31/17 , A61P35/00 , C07D335/02 , C07C229/00 , A61K31/136 , C07D409/12
CPC分类号： C07C275/40 , A61K31/17 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07C229/42 , C07C233/81 , C07C235/38 , C07C235/56 , C07C255/57 , C07C255/58 , C07C275/30 , C07C275/42 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/08 , C07D211/14 , C07D239/34 , C07D239/47 , C07D265/30 , C07D265/36 , C07D277/64 , C07D295/155 , C07D307/22 , C07D309/04 , C07D309/14 , C07D317/46 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：EP3924336A1
公开(公告)日：2021-12-22
申请号：EP20711418.2
申请日：2020-02-14
发明人： WACKER, Dean A. , NARA, Susheel Jethanand , CHERUKU, Srinivas , SARKUNAM, Kandhasamy , JAIPURI, Firoz Ali , THANGAVEL, Soodamani , NARAYAN, Rishikesh , BANDREDDY, Subba Reddy , JOGI, Srinivas , KATHI, Pavan Kalyan
IPC分类号： C07D217/06 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , A61K31/427 , A61P3/06 , A61P13/00 , A61P35/00
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公开(公告)号：EP3924333A1
公开(公告)日：2021-12-22
申请号：EP20712112.0
申请日：2020-02-14
发明人： WACKER, Dean A. , NARA, Susheel Jethanand , CHERUKU, Srinivas , SARKUNAM, Kandhasamy , JAIPURI, Firoz Ali , THANGAVEL, Soodamani , NARAYAN, Rishikesh , JOGI, Srinivas , KATHI, Pavan Kalyan
IPC分类号： C07D213/24 , C07D231/12 , C07D271/06 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , A61K31/4245 , A61K31/415 , A61P3/06 , A61P13/00 , A61P35/00
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公开(公告)号：EP3362441B1
公开(公告)日：2020-08-12
申请号：EP16790475.4
申请日：2016-10-13
发明人： ISLAM, Imadul , THANGATHIRUPATHY, Srinivasan , WARRIER, Jayakumar Sankara , CHERUKU, Srinivas , SHETTY, Poornima , GUPTA, Grandhi Venkat Ram Krishna Mohan , MACOR, John E.
IPC分类号： C07D401/12 , C07D471/08 , A61K31/496 , A61P25/02 , A61P25/24 , A61P25/28
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公开(公告)号：EP3924329A2
公开(公告)日：2021-12-22
申请号：EP20715505.2
申请日：2020-02-14
发明人： WACKER, Dean A. , NARA, Susheel Jethanand , CHERUKU, Srinivas , SARKUNAM, Kandhasamy , JAIPURI, Firoz Ali , THANGAVEL, Soodamani , NARAYAN, Rishikesh , BANDREDDY, Subba Reddy , JOGI, Srinivas , KATHI, Pavan Kalyan
IPC分类号： C07C233/56 , A61K31/165 , A61K31/35 , A61K31/4196 , C07D271/06 , C07D277/64 , C07D295/04 , C07D405/04 , C07D405/14 , C07D413/04
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公开(公告)号：EP3362447B1
公开(公告)日：2020-08-26
申请号：EP16787974.1
申请日：2016-10-13
发明人： ISLAM, Imadul , THANGATHIRUPATHY, Srinivasan , WARRIER, Jayakumar Sankara , CHERUKU, Srinivas , SHETTY, Poornima , MACOR, John E.
IPC分类号： C07D413/14 , C07D413/04 , A61K31/454 , A61K31/4439 , A61K31/5355 , A61K31/496 , A61P25/02 , A61P25/16 , A61P25/28 , A61P25/24
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公开(公告)号：EP3362447A1
公开(公告)日：2018-08-22
申请号：EP16787974.1
申请日：2016-10-13
发明人： ISLAM, Imadul , THANGATHIRUPATHY, Srinivasan , WARRIER, Jayakumar Sankara , CHERUKU, Srinivas , SHETTY, Poornima , MACOR, John E.
IPC分类号： C07D413/14 , C07D413/04 , A61K31/454 , A61K31/4439 , A61K31/5355 , A61K31/496 , A61P25/02 , A61P25/16 , A61P25/28 , A61P25/24
摘要： The present disclosure provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) compounds are ligands for NR2B N-Methyl-D-aspartate (NMD A) receptor and thereby making them useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：EP3924337A1
公开(公告)日：2021-12-22
申请号：EP20711421.6
申请日：2020-02-14
发明人： WACKER, Dean A. , NARA, Susheel Jethanand , CHERUKU, Srinivas , SARKUNAM, Kandhasamy , JAIPURI, Firoz Ali , NARAYAN, Rishikesh , BANDREDDY, Subba Reddy , JOGI, Srinivas
IPC分类号： C07D217/06 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , A61K31/427 , A61P3/06 , A61P13/00 , A61P35/00
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公开(公告)号：EP3704113A1
公开(公告)日：2020-09-09
申请号：EP18804187.5
申请日：2018-10-31
发明人： YOON, David S. , ANUMULA, Rushith Kumar , CHERUKU, Srinivas , HUANG, Yanting , JURICA, Elizabeth Anne , MENG, Wei , NARA, Susheel Jethanand , NARAYAN, Rishikesh , SISTLA, Ramesh Kumar , WU, Ximao , ZHAO, Guohua
IPC分类号： C07D413/14 , C07D413/04 , A61K31/422 , A61K31/4245 , A61K31/428 , A61K31/429 , C07D417/12 , C07D417/14 , C07D471/04 , C07D261/08
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