摘要:
An object of the present invention is to find a method for easily synthesizing cyclopropylphenol derivatives. The object of the present invention is to find a process for producing a cyclopropylphenol derivative represented by general formula (10):
[wherein R 1 , R 2 , R 3 and R 4 each independently represent a hydrogen atom or the like; Z represents a hydrogen atom or the like; and Y 1 , Y 2 and Y 3 each independently represent a hydrogen atom or the like]; and solved by the process comprising reacting a compound represented by general formula (7):
[wherein each of the symbols are the same as previously defined; X represents a halogen atom; and V represents a hydrogen atom or the like], with a metal, metal salt or organometallic compound represented by general formula (8): M 2 to obtain a compound represented by general formula (9):
[wherein each of the symbols are the same as previously defined] and obtaining a compound represented by general formula (10) by hydrolysis in the case V represents the group, -W-R 5 .
摘要:
According to the present invention, a process for the preparation of a cyclopropylacetylene derivative represented by the following formula (III): is provided, which comprises reacting a cyclopropylacrylic acid derivative represented by the following formula (I): with a halogenating agent to obtain a halogenocyclopropylpropionic acid derivative represented by the following formula (II): and reacting the halogenocyclopropylpropionic acid derivative with a base. In the above formulae, R 1 ,R 2 ,R 3 ,R 4 and R 5 represent a hydrogen atom or an eventually substituted alkyl group, R 6 and R 8 represent a hydrogen atom, an eventually subtituted alkyl group or an eventually protected carboxyl group, R 7 represents a hydrogen atom or a carboxyl protecting group, and X and Y represent a halogen atom.
摘要:
Es werden neue 2-Halogencyclopropylethanderivate der allgemeinen Formel I und neue Zwischenprodukte der allgemeinen Formel II in denen R 1 , R 2 , R 3 , A und X die in der Beschreibung genannten Bedeutungen haben, sowie Verfahren zur Herstellung der Verbindungen der allgemeinen Formel I beschrieben. Die erfindungsgemäßen Verbindungen können als Schädlingsbekämpfungsmittel, insbesondere gegen Insekten und Milben, verwendet werden.
摘要:
The invention provides a novel method for producing a fluorinated organic compound. The method for producing a fluorinated organic compound comprises reacting a compound represented by formula (1):
(wherein R 1 and R 2 are each independently a hydrogen atom, a halogen atom, or an organic group, or R 1 and R 2 optionally form a ring together with the two adjacent carbon atoms; n is 1 or 2; and wherein two R 1 s are optionally the same or different, two R 2 s are optionally the same or different, or two R 1 s or two R 2 s optionally form a ring together with their adjacent carbon atom), with (A) at least one fluorine source selected from the group consisting of hydrogen fluoride, hydrogen fluoride salts, and fluoride salts, and (B) a halogen source other than fluorine represented by the formula: R 3 (OX) m (wherein R 3 is a hydrogen atom, a cation, or an organic group, X is a halogen atom other than a fluorine atom, and m is an integer corresponding to the valence of R 3 ), to add fluorine and a halogen other than fluorine to the double bond or triple bond.
摘要:
The present invention provides an asymmetric and economic synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine via novel intermediates applying an asymmetric enzymatic, biomimetic or catalytic reduction. The present invention also provides a novel green asymmetric catalytic reduction adapted for an aqueous medium to be applied in the synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine or novel intermediates.