PROCESS FOR PRODUCING CYCLOPROPYLPHENOL DERIVATIVE
    2.
    发明公开
    PROCESS FOR PRODUCING CYCLOPROPYLPHENOL DERIVATIVE 审中-公开
    生产环丙基苯酚衍生物的方法

    公开(公告)号:EP1880987A1

    公开(公告)日:2008-01-23

    申请号:EP06730754.6

    申请日:2006-03-31

    摘要: An object of the present invention is to find a method for easily synthesizing cyclopropylphenol derivatives. The object of the present invention is to find a process for producing a cyclopropylphenol derivative represented by general formula (10):

    [wherein R 1 , R 2 , R 3 and R 4 each independently represent a hydrogen atom or the like; Z represents a hydrogen atom or the like; and Y 1 , Y 2 and Y 3 each independently represent a hydrogen atom or the like];
    and solved by the process comprising reacting a compound represented by general formula (7):

    [wherein each of the symbols are the same as previously defined; X represents a halogen atom; and V represents a hydrogen atom or the like],
    with a metal, metal salt or organometallic compound represented by general formula (8): M 2 to obtain a compound represented by general formula (9):

    [wherein each of the symbols are the same as previously defined] and obtaining a compound represented by general formula (10) by hydrolysis in the case V represents the group, -W-R 5 .

    摘要翻译: 本发明的一个目的是找到一种容易合成环丙基苯酚衍生物的方法。 本发明的目的是找到一种制备通式(10)表示的环丙基苯酚衍生物的方法:[其中R1,R2,R3和R4各自独立地代表氢原子等; Z表示氢原子等; Y 1,Y 2和Y 3各自独立地表示氢原子等]。 并通过包括使由通式(7)表示的化合物:[其中每个符号与前​​述定义相同; X代表卤素原子; (8)表示的金属,金属盐或有机金属化合物与通式(9)表示的化合物反应,得到通式(9)所示的化合物,式中,各符号相同 如前所定义],并且在V表示基团-W-R5的情况下通过水解获得通式(10)表示的化合物。

    METHOD FOR PRODUCING FLUORINATED ORGANIC COMPOUND

    公开(公告)号:EP4265589A1

    公开(公告)日:2023-10-25

    申请号:EP21906736.0

    申请日:2021-12-17

    摘要: The invention provides a novel method for producing a fluorinated organic compound. The method for producing a fluorinated organic compound comprises reacting a compound represented by formula (1):

    (wherein R 1 and R 2 are each independently a hydrogen atom, a halogen atom, or an organic group, or R 1 and R 2 optionally form a ring together with the two adjacent carbon atoms; n is 1 or 2;
    and wherein two R 1 s are optionally the same or different, two R 2 s are optionally the same or different, or two R 1 s or two R 2 s optionally form a ring together with their adjacent carbon atom), with (A) at least one fluorine source selected from the group consisting of hydrogen fluoride, hydrogen fluoride salts, and fluoride salts, and (B) a halogen source other than fluorine represented by the formula: R 3 (OX) m (wherein R 3 is a hydrogen atom, a cation, or an organic group, X is a halogen atom other than a fluorine atom, and m is an integer corresponding to the valence of R 3 ), to add fluorine and a halogen other than fluorine to the double bond or triple bond.