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1.发明授权FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION 有权缩合杂环琥珀酰亚胺及其类似物，受体核激素的功能调节剂
公开(公告)号：EP1458723B1
公开(公告)日：2008-10-15
申请号：EP02797421.1
申请日：2002-12-18
发明人： SALVATI, Mark, E. , BALOG, James, Aaron , PICKERING, Dacia, A. , GIESE, Soren , FURA, Aberra , LI, Wenying , PATEL, Ramesh, N. , HANSON, Ronald, L. , MITT, Toomas , ROBERGE, Jacques , CORTE, James, R. , SPERGEL, Steven, H. , RAMPULLA, Richard, A. , MISRA, Raj , XIAO, Hai-Yun
IPC分类号： C07D491/00 , A61K31/40 , A61P35/00
CPC分类号： C07D491/18 , C07D491/22 , C07D519/00
摘要： Fused cyclic compounds method of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
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2.发明公开METHODS AND COMPOUNDS PRODUCING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREOF 有权方法和化合物生产二肽基肽酶IV抑制剂及其中间体
公开(公告)号：EP1581487A2
公开(公告)日：2005-10-05
申请号：EP03812799.9
申请日：2003-12-04
发明人： VU, Truc, Chi , BRZOZOWSKI, David, B. , FOX, Rita , GODFREY, Jollie, Duaine, Jr. , HANSON, Ronald, L. , KOLOTUCHIN, Sergei, V. , MAZZULLO, John, A., Jr. , PATEL, Ramesh, N. , WANG, Jianji , WONG, Kwok , YU, Jurong , ZHU, Jason , MAGNIN, David, R. , AUGERI, David, J. , HAMANN, Lawrence, G.
IPC分类号： C07D201/00
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译： 提供了用于生产二肽基肽酶IV的cycloproyl稠合的基于吡咯烷的抑制剂的方法和化合物。
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3.发明公开Methods and Compounds for Producing Dipeptidyl Peptidase IV Inhibitors and Intermediates thereof 有权生产二肽基肽酶IV抑制剂及其中间体的方法和化合物
公开(公告)号：EP2505578A3
公开(公告)日：2013-07-31
申请号：EP12162626.1
申请日：2003-12-04
发明人： VU, Truc, Chi , FOX, Rita , HANSON, Ronald, L. , MAZZULLO, John, A., Jr. , WANG, Jianji , YU, Jurong , MAGNIN, David, R. , HAMANN, Lawrence, G. , BRZOZOWSKI, David, B. , GODFREY, Jollie, Duaine, Jr. , KOLOTUCHIN, Sergei, V. , PATEL, Ramesh, N. , WONG, Kwok , ZHU, Jason , AUGERI, David, J.
IPC分类号： C07C62/06 , C07C229/28 , C07C271/22 , C07D207/22 , C07D209/52 , C07C69/635 , C07C69/675 , C07C69/757
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cycloproyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译： 提供了用于生产二肽基肽酶IV的基于环丙酰基稠合吡咯烷的抑制剂的方法和化合物。
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公开(公告)号：EP1105380B1
公开(公告)日：2004-02-25
申请号：EP99937759.1
申请日：1999-08-03
IPC分类号： C07D305/14 , C12N9/00 , C12P17/02 , C12P15/00
CPC分类号： C07D305/14 , C12P15/00
摘要： A process useful for the preparation of intermediates in synthesis or semi-synthesis of paclitaxel analogs wherein a starting taxane such as 10-deacetylbaccatin III is deacetylated at the C-4 position using a microorganism or an enzyme derived therefrom to provide 4-deacetyltaxanes, such as 4,10-dideacetylbaccatin III.
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公开(公告)号：EP1105380A1
公开(公告)日：2001-06-13
申请号：EP99937759.1
申请日：1999-08-03
IPC分类号： C07D305/14 , C12N9/00 , C12P17/02
CPC分类号： C07D305/14 , C12P15/00
摘要： A process useful for the preparation of intermediates in synthesis or semi-synthesis of paclitaxel analogs wherein a starting taxane such as 10-deacetylbaccatin III is deacetylated at the C-4 position using a microorganism or an enzyme derived therefrom to provide 4-deacetyltaxanes, such as 4,10-dideacetylbaccatin III.
摘要翻译： 可用于制备紫杉醇类似物的合成或半合成中的中间体的方法，其中起始紫杉烷例如10-脱乙酰基浆果赤霉素III在C-4位使用微生物或由其衍生的酶脱乙酰化得到4-脱乙酰基紫杉烷，例如 作为4,10-二脱乙酰基浆果赤霉素III。
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6.发明公开Methods and Compounds for Producing Dipeptidyl Peptidase IV Inhibitors and Intermediates thereof 有权的方法和化合物对二肽基肽酶IV抑制剂和其中间体的制备
公开(公告)号：EP2505578A2
公开(公告)日：2012-10-03
申请号：EP12162626.1
申请日：2003-12-04
发明人： VU, Truc, Chi , FOX, Rita , HANSON, Ronald, L. , MAZZULLO, John, A., Jr. , WANG, Jianji , YU, Jurong , MAGNIN, David, R. , HAMANN, Lawrence, G. , BRZOZOWSKI, David, B. , GODFREY, Jollie, Duaine, Jr. , KOLOTUCHIN, Sergei, V. , PATEL, Ramesh, N. , WONG, Kwok , ZHU, Jason , AUGERI, David, J.
IPC分类号： C07C62/06 , C07C229/28 , C07C271/22 , C07D207/22 , C07D209/52 , C07C69/635 , C07C69/675 , C07C69/757
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cycloproyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译： 提供了用于生产二肽基肽酶IV的cycloproyl稠合的基于吡咯烷的抑制剂的方法和化合物。
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7.发明授权FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION 有权缩合杂环琥珀酰亚胺及其类似物，受体功能核激素的调节剂
公开(公告)号：EP1319007B9
公开(公告)日：2007-10-10
申请号：EP01948503.6
申请日：2001-06-20
发明人： SALVATI, Mark, E. , BALOG, James, Aaron , PICKERING, Dacia, A. , GIESE, Sören , FURA, Aberra , LI, Wenying , PATEL, Ramesh, N. , HANSON, Ronald, L.
IPC分类号： C07D491/08 , C07D495/08 , C07D471/08 , A61K31/40 , A61K31/439 , A61P35/00
CPC分类号： C07D487/08 , A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , A61K2300/00
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
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8.发明授权FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION 有权缩合杂环琥珀酰亚胺及其类似物，受体功能核激素的调节剂
公开(公告)号：EP1319007B1
公开(公告)日：2006-03-01
申请号：EP01948503.6
申请日：2001-06-20
发明人： SALVATI, Mark, E. , BALOG, James, Aaron , PICKERING, Dacia, A. , GIESE, Sören , FURA, Aberra , LI, Wenying , PATEL, Ramesh, N. , HANSON, Ronald, L.
IPC分类号： C07D491/08 , C07D495/08 , C07D471/08 , A61K31/40 , A61K31/439 , A61P35/00
CPC分类号： C07D487/08 , A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , A61K2300/00
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
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公开(公告)号：EP1097236A1
公开(公告)日：2001-05-09
申请号：EP99933744.7
申请日：1999-07-07
发明人： DONOVAN, Mary, Jo , GOLDBERG, Steven , HANSON, Ronald, L. , JASS, Paul, A. , LI, Wen-Sen , PATEL, Ramesh, N. , RAMIG, Keith , SZARKA, Laszlo, J. , VENIT, John, J.
CPC分类号： C12N9/0018 , C12P7/62 , C12P41/002 , C12P41/006
摘要： Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.
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