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公开(公告)号：EP3953334A1
公开(公告)日：2022-02-16
申请号：EP20721374.5
申请日：2020-04-10
发明人： CUNIERE, Nicolas , FAN, Yu , KOLOTUCHIN, Sergei , MUKHERJEE, Subha , SIMMONS, Eric M. , SINGH, Amarjit , WEI, Carolyn S. , XIAO, Yi , YUAN, Changxia , ZHENG, Bin , WAGSCHAL, Simon Albert , BROGGINI, Diego Fernando Domenico , CAO, Duy Chi Trung , CHERNICHENKO, Kostiantyn , LEMAIRE, Sébastien François Emmanuel , BEN HAIM, Cyril
IPC分类号： C07D213/61 , C07D401/04 , C07D471/18
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公开(公告)号：EP4234555A3
公开(公告)日：2024-01-03
申请号：EP23169596.6
申请日：2020-04-10
发明人： CUNIERE, Nicolas , FAN, Yu , KOLOTUCHIN, Sergei , MUKHERJEE, Subha , SIMMONS, Eric M. , SINGH, Amartjit , WEI, Carolyn S. , XIAO, Yi , YUAN, Changxia , ZHENG, Bin , WAGSCHAL, Simon Albert , BROGGINI, Diego Fernando Domenico , CAO, Duy Chi Trung , CHERNICHENKO, Kostiantyn , LEMAIRE, Sébastien François Emmanuel , BEN HAIM, Cyril
IPC分类号： C07D471/18 , C07D401/04 , C07D213/61
摘要： Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.
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公开(公告)号：EP4234555A2
公开(公告)日：2023-08-30
申请号：EP23169596.6
申请日：2020-04-10
发明人： CUNIERE, Nicolas , FAN, Yu , KOLOTUCHIN, Sergei , MUKHERJEE, Subha , SIMMONS, Eric M. , SINGH, Amartjit , WEI, Carolyn S. , XIAO, Yi , YUAN, Changxia , ZHENG, Bin , WAGSCHAL, Simon Albert , BROGGINI, Diego Fernando Domenico , CAO, Duy Chi Trung , CHERNICHENKO, Kostiantyn , LEMAIRE, Sébastien François Emmanuel , BEN HAIM, Cyril
IPC分类号： C07D471/18
摘要： Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.
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公开(公告)号：EP3882237A3
公开(公告)日：2021-11-03
申请号：EP21155321.9
申请日：2018-03-29
发明人： CHEN, Ke , DEERBERG, Joerg , LIN, Dong , DUMMELDINGER, Michael , INANKUR, Bahar , KOLOTUCHIN, Sergei V. , LI, Jun , ROGERS, Amanda J. , ROSSO, Victor W. , SIMMONS, Eric M. , SOUMEILLANT, Maxime C. D. , TREITLER, Daniel S. , WANG, Jianji , ZHENG, Bin , SMITH, Michael J. , STROTMAN, Neil A. , TYMONKO, Steven , BENKOVICS, Tamas
IPC分类号： C07D249/08 , C07C209/02 , C07C211/04
摘要： The invention relates to an improved process for synthesizing 6-(cyciopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula:
Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.-
公开(公告)号：EP3921323A1
公开(公告)日：2021-12-15
申请号：EP20709068.9
申请日：2020-02-05
发明人： YUAN, Changxia , SCHMIDT, Michael Anthony , ORTIZ, Adrian , ROGERS, Amanda J. , ZHU, Jason J. , ZHONGMIN, Xu , YU, Miao , SIMMONS, Eric M. , WU, Shulin
IPC分类号： C07H1/00 , C07H5/06 , C07H19/167
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公开(公告)号：EP3601268A1
公开(公告)日：2020-02-05
申请号：EP18718340.5
申请日：2018-03-29
发明人： CHEN, Ke , DEERBERG, Joerg , LIN, Dong , DUMMELDINGER, Michael , INANKUR, Bahar , KOLOTUCHIN, Sergei V. , LI, Jun , ROGERS, Amanda J. , ROSSO, Victor W. , SIMMONS, Eric M. , SOUMEILLANT, Maxime C. D. , TREITLER, Daniel S. , WANG, Jianji , ZHENG, Bin , SMITH, Michael J. , STROTMAN, Neil A. , TYMONKO, Steven , BENKOVICS, Tamas
IPC分类号： C07D403/12 , A61K31/501 , A61P29/00
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公开(公告)号：EP3882237A2
公开(公告)日：2021-09-22
申请号：EP21155321.9
申请日：2018-03-29
发明人： CHEN, Ke , DEERBERG, Joerg , LIN, Dong , DUMMELDINGER, Michael , INANKUR, Bahar , KOLOTUCHIN, Sergei V. , LI, Jun , ROGERS, Amanda J. , ROSSO, Victor W. , SIMMONS, Eric M. , SOUMEILLANT, Maxime C. D. , TREITLER, Daniel S. , WANG, Jianji , ZHENG, Bin , SMITH, Michael J. , STROTMAN, Neil A. , TYMONKO, Steven , BENKOVICS, Tamas
IPC分类号： C07D249/08
摘要： The invention relates to an improved process for synthesizing 6-(cyciopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula:
Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.
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