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公开(公告)号:EP4225757A1
公开(公告)日:2023-08-16
申请号:EP21805719.8
申请日:2021-10-11
发明人: MUKHERJEE, Subha , GALLAGHER, William P. , JAMISON, Christopher Robert , WEI, Carolyn S. , KOLOTUCHIN, Sergei , SINGH, Amarjit , CUNIERE, Nicolas , SFOUGGATAKIS, Chris , ORTIZ, Adrian , WISNIEWSKI, Steven R. , ZHENG, Bin , LUO, Helen Y. , LEMAIRE, Sébastien François Emmanuel , BEN HAÏM, Cyril , CHERNICHENKO, Kostiantyn , BROGGINI, Diego Fernando Domenico , WAGSCHAL, Simon Albert , CAO, Duy Chi Trung , REUTER, Karl , SCHMALZBAUER, Björn , KOSCHKER, Philipp , EASTGATE, Martin D. , SKLIAR, Dimitri , ZHDANKO, Alexander , XIOURAS, Christos , MOWER, Matthew Penfield , TRAN, Ngoc Duc , RAHMANI, Ramdane , JUSSEAU, Xavier Jean-Marie , MATCHA, Kiran , PEREGO, Luca Alessandro
IPC分类号: C07D471/18 , C07D213/61 , C07D249/06 , C07B57/00
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公开(公告)号:EP4090664A1
公开(公告)日:2022-11-23
申请号:EP21741301.2
申请日:2021-01-14
发明人: XU, Dongmin , RIVAS-BASCÓN, Nazaret , KNOUSE, Kyle W. , PADIAL, Natalia M. , ZHENG, Bin , VANTOUROUT, Julien C. , SCHMIDT, Michael A. , EASTGATE, Martin D. , BARAN, Phil S.
IPC分类号: C07F9/02 , C07F9/6564 , C07F9/6578
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公开(公告)号:EP3891160A1
公开(公告)日:2021-10-13
申请号:EP19828401.0
申请日:2019-12-03
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公开(公告)号:EP4296258A2
公开(公告)日:2023-12-27
申请号:EP23209227.0
申请日:2018-03-29
发明人: CHEN, Ke , DEERBERG, Joerg , LIN, Dong , DUMMELDINGER, Michael , INANKUR, Bahar , KOLOTUCHIN, Sergei V , LI, Jun , ROGERS, Amanda J , ROSSO, Victor W , SIMMONS, Eric M , SOUMEILLANT, Maxime C. D , TREITLER, Daniels S , WANG, Jianji , ZHENG, Bin , SMITH, Michael J , STROTMAN, Neil A , TYMONKO, Steven , BENKOVICS, Tamas
IPC分类号: C07C211/04
摘要: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula:
Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.-
公开(公告)号:EP3953334A1
公开(公告)日:2022-02-16
申请号:EP20721374.5
申请日:2020-04-10
发明人: CUNIERE, Nicolas , FAN, Yu , KOLOTUCHIN, Sergei , MUKHERJEE, Subha , SIMMONS, Eric M. , SINGH, Amarjit , WEI, Carolyn S. , XIAO, Yi , YUAN, Changxia , ZHENG, Bin , WAGSCHAL, Simon Albert , BROGGINI, Diego Fernando Domenico , CAO, Duy Chi Trung , CHERNICHENKO, Kostiantyn , LEMAIRE, Sébastien François Emmanuel , BEN HAIM, Cyril
IPC分类号: C07D213/61 , C07D401/04 , C07D471/18
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公开(公告)号:EP3601268A1
公开(公告)日:2020-02-05
申请号:EP18718340.5
申请日:2018-03-29
发明人: CHEN, Ke , DEERBERG, Joerg , LIN, Dong , DUMMELDINGER, Michael , INANKUR, Bahar , KOLOTUCHIN, Sergei V. , LI, Jun , ROGERS, Amanda J. , ROSSO, Victor W. , SIMMONS, Eric M. , SOUMEILLANT, Maxime C. D. , TREITLER, Daniel S. , WANG, Jianji , ZHENG, Bin , SMITH, Michael J. , STROTMAN, Neil A. , TYMONKO, Steven , BENKOVICS, Tamas
IPC分类号: C07D403/12 , A61K31/501 , A61P29/00
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公开(公告)号:EP1694683A2
公开(公告)日:2006-08-30
申请号:EP04814139.4
申请日:2004-12-10
发明人: SWAMINATHAN, Shankar , GAVAI, Ashvinikumar V. , FAN, Junying , PATEL, Bharat P. , NORRIS, Derek J. , CORBETT, Richard Michael , ZHENG, Bin
IPC分类号: C07D487/04 , A61K31/53 , A61P35/00
CPC分类号: C07D487/04
摘要: The present invention provides a process for preparing compounds of formula (I) ['insert chemical structure here'](I)or a pharmaceutically acceptable salt thereof. The compounds prepared by the process of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
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公开(公告)号:EP4234555A3
公开(公告)日:2024-01-03
申请号:EP23169596.6
申请日:2020-04-10
发明人: CUNIERE, Nicolas , FAN, Yu , KOLOTUCHIN, Sergei , MUKHERJEE, Subha , SIMMONS, Eric M. , SINGH, Amartjit , WEI, Carolyn S. , XIAO, Yi , YUAN, Changxia , ZHENG, Bin , WAGSCHAL, Simon Albert , BROGGINI, Diego Fernando Domenico , CAO, Duy Chi Trung , CHERNICHENKO, Kostiantyn , LEMAIRE, Sébastien François Emmanuel , BEN HAIM, Cyril
IPC分类号: C07D471/18 , C07D401/04 , C07D213/61
摘要: Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.
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公开(公告)号:EP4234555A2
公开(公告)日:2023-08-30
申请号:EP23169596.6
申请日:2020-04-10
发明人: CUNIERE, Nicolas , FAN, Yu , KOLOTUCHIN, Sergei , MUKHERJEE, Subha , SIMMONS, Eric M. , SINGH, Amartjit , WEI, Carolyn S. , XIAO, Yi , YUAN, Changxia , ZHENG, Bin , WAGSCHAL, Simon Albert , BROGGINI, Diego Fernando Domenico , CAO, Duy Chi Trung , CHERNICHENKO, Kostiantyn , LEMAIRE, Sébastien François Emmanuel , BEN HAIM, Cyril
IPC分类号: C07D471/18
摘要: Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.
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公开(公告)号:EP3882237A2
公开(公告)日:2021-09-22
申请号:EP21155321.9
申请日:2018-03-29
发明人: CHEN, Ke , DEERBERG, Joerg , LIN, Dong , DUMMELDINGER, Michael , INANKUR, Bahar , KOLOTUCHIN, Sergei V. , LI, Jun , ROGERS, Amanda J. , ROSSO, Victor W. , SIMMONS, Eric M. , SOUMEILLANT, Maxime C. D. , TREITLER, Daniel S. , WANG, Jianji , ZHENG, Bin , SMITH, Michael J. , STROTMAN, Neil A. , TYMONKO, Steven , BENKOVICS, Tamas
IPC分类号: C07D249/08
摘要: The invention relates to an improved process for synthesizing 6-(cyciopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula:
Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.
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