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1.发明公开PHARMACEUTICAL PREPARATION CONTAINING MODIFICATIONS OF SURFACTANT PROTEIN B (SP-B) AND SURFACTANT PROTEIN C (SP-C) 审中-公开药物制备含表面活性剂蛋白B（SP-B）和表面活性蛋白C的修饰（SP-C）
公开(公告)号：EP1189625A1
公开(公告)日：2002-03-27
申请号：EP00938727.5
申请日：2000-06-02
IPC分类号： A61K38/17 , A61P11/00 , C07K14/785
CPC分类号： C07K14/785 , A61K9/0082 , A61K38/1709
摘要： The invention describes a novel pharmaceutical preparation for treating IRDS or ALI, comprising at least one modification of surfactant protein B (SP-B) and at least one modification of surfactant protein C (SP-C).
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2.发明授权
公开(公告)号：EP0877602B1
公开(公告)日：2002-01-23
申请号：EP97902186.2
申请日：1997-01-18
发明人： EISTETTER, Klaus
IPC分类号： A61K9/14 , C07K14/785
CPC分类号： A61K38/1709 , A61K9/0082 , A61K9/1688
摘要： The invention concerns a process for the production of a powdered pulmonary surfactant preparation containing a hydrophobic protein serving as a pulmonary surfactant characterized by the fact that an organic solution or suspension containing a hydrophobic protein serving as a pulmonary surfactant and possibly other components is subject to spray drying. Powder preparations are obtained that exhibit very good stability under storage, are easy to reconstitute and which are also suitable for administration by inhalation.
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公开(公告)号：EP0302871A1
公开(公告)日：1989-02-15
申请号：EP87902503.0
申请日：1987-04-17
发明人： FLOCKERZI, Dieter , AMSCHLER, Hermann , EISTETTER, Klaus , ELTZE, Manfrid , KLEMM, Kurt , KOLASSA, Norbert , SANDERS, Karl , SCHUDT, Christian , ULRICH, Wolf-Rüdiger
CPC分类号： C07D413/14 , C07D211/90 , C07D401/12
摘要： Dihydropyridine de formule (I) dans laquelle R6 et R7 représentent conjointement, et y compris l'atome d'azote auquel ils sont tous deux liés, un résidu de formule (II), dans laquelle A est -CH2-C(R8)R9-CH2-; R8 est aryle et R9 est aryle, aryle représentant un composé cyclique de formule (III) dans laquelle R10 et R11 sont identiques ou différents et sont hydrogène, alkyle, alkoxy, halogène, hydroxy ou trifluorométhyle, et où soit E est alkylène, R2 amino et R3 alkyle ou alkoxyalkyle, soit E est A1-0-A2, R2 est hydrogène, alkyle ou alkoxyalkyle et R3 est hydrogène, alkyle ou alkoxyalkyle, A1 étant alkylène et A2 étant alkylène ou alkylèneoxy-alkylène. Sont également décrits les sels de ces composés, ainsi qu'un procédé pour leur production et leur utilisation comme médicaments.
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公开(公告)号：EP1131055A1
公开(公告)日：2001-09-12
申请号：EP99971701.0
申请日：1999-11-09
CPC分类号： A61K38/1709 , A61K9/0082
摘要： The invention describes a set for the treatment of IRDS, ALI or ARDS, comprising a first container which has a volume of 50 to 500 ml and contains a pulverulent pulmonary surfactant preparation, the amount of phospholipids in the container being 50 to 500 mg, and a second container which has a volume of 50 to 500 ml and contains a pulverulent pulmonary surfactant preparation, where the amount of phospholipids in the second container is 1 to 10 g.
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5.发明公开COMPOSITIONS COMPRISING PHENYLAMINOTHIOPHENACETIC ACID DERIVATIVES FOR THE TREATMENT OF ACUTE OR ADULT RESPIRATORY DISTRESS SYNDROME (ARDS) AND INFANT RESPIRATORY DISTRESS SYNDROME (IRDS) 有权制备含PHENYLAMINOTHIOPHENESSIGSÄURE的衍生物对急性呼吸功能不全（ARDS）和急性呼吸功能不全IN儿童的治疗（IRDS）
公开(公告)号：EP1098645A1
公开(公告)日：2001-05-16
申请号：EP99931116.0
申请日：1999-06-19
IPC分类号： A61K31/38
CPC分类号： A61K31/38
摘要： Novel compositions for the treatment of IRDS and ARDS are indicated which contain a compound of formula (I), in which R1 is hydrogen or 2-(2-hydroxyethoxy)ethyl and/or a pharmacologically tolerable salt of this compound and lung surfactant.
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公开(公告)号：EP0343193A1
公开(公告)日：1989-11-29
申请号：EP88903212.0
申请日：1988-03-24
发明人： ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , FLOCKERZI, Dieter , KLEMM, Kurt , KOHL, Bernhard , EISTETTER, Klaus , ELTZE, Manfrid , KOLASSA, Norbert , SANDERS, Karl , SCHUDT, Christian
CPC分类号： C07D405/12 , C07D211/90 , C07D401/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04
摘要： Des dihydropyridines énantiomériquement pures de formule (I), dans laquelle les substituants et les symboles ont les notations indiquées dans la description, sont de nouveaux composés présentant des propriétés pharmacologiques étonnantes. Un nouveau procédé pour fabriquer ces composés est décrit.
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7.发明公开
公开(公告)号：EP0231367A1
公开(公告)日：1987-08-12
申请号：EP86905250.0
申请日：1986-07-29
发明人： WOLF, Horst , EISTETTER, Klaus
CPC分类号： A61K31/335 , Y10S514/824
摘要： Utilisation d'acides carboxyliques d'oxirane de formule (I), dans laquelle R1, R2, R3, Y et n ont les significations indiquées dans les revendications, pour la prévention et/ou le traitement d'infections associées à une concentration accrue de cholesterol et/ou de triglyceride.
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8.发明公开COMPOSITIONS FOR THE TREATMENT OF ARDS OR IRDS CONTAINING 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLORO-4-PYRIDINYL)-4-(DIFLUOROMETHOXY)BENZAMIDE AND LUNG SURFACTANT 无效FOR治疗ARDS的组合物或IRDS 3-（CALCOPROPYLMETHOXY）-N-（3,5-二氯-4-吡啶基）-4-（二氟甲氧基）苯甲酰胺和肺表面活性剂CONTAIN
公开(公告)号：EP0977577A1
公开(公告)日：2000-02-09
申请号：EP98910670.3
申请日：1998-02-14
发明人： GERMANN, Paul-Georg , KILIAN, Ulrich , BEUME, Rolf , AMSCHLER, Hermann , KRÜGER, Uwe , HÄFNER, Dietrich , EISTETTER, Klaus
IPC分类号： A61K31/66
CPC分类号： A61K31/685 , A61K31/44 , A61K38/1709 , A61K45/06 , A61K2300/00
摘要： Composition for the treatment of infant or adult respiratory distress syndrome (IRDS and ARDS) contains N-(3,5-dichloropyrid-4-yl)-3- cyclopropylmethoxy-4- difluoromethoxybenzamide (II) (and/or its salts) and a lung surfactant.
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9.发明公开
公开(公告)号：EP0877602A1
公开(公告)日：1998-11-18
申请号：EP97902186.0
申请日：1997-01-18
发明人： EISTETTER, Klaus
CPC分类号： A61K38/1709 , A61K9/0082 , A61K9/1688
摘要： The invention concerns a process for the production of a powdered pulmonary surfactant preparation containing a hydrophobic protein serving as a pulmonary surfactant characterized by the fact that an organic solution or suspension containing a hydrophobic protein serving as a pulmonary surfactant and possibly other components is subject to spray drying. Powder preparations are obtained that exhibit very good stability under storage, are easy to reconstitute and which are also suitable for administration by inhalation.
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10.发明公开ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON IRDS UND ARDS, DIE MINDESTENS EIN GLUCOCORTICOSTEROID IN KOMBINATION MIT EINEM LUNGEN SURFACTANT ENTHALTEN 失效组合物治疗IRDS和ARDS至少一个糖皮质激素结合肺含有表面活性剂
公开(公告)号：EP0783314A2
公开(公告)日：1997-07-16
申请号：EP95935387.0
申请日：1995-09-27
CPC分类号： A61K35/42 , A61K38/1709 , A61K31/58 , A61K31/57 , A61K2300/00
摘要： Novel compositions are disclosed for the treatment of IRDS and ARDS, containing at least one glucocorticosteroid and a pulmonary surfactant. The duration of treatment and the mortality associated with these syndromes can be significantly reduced with the proposed novel compositions.
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